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Cited by 143Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersNeural dynamics and brain function

Density and morphology of dendritic spines in mouse neocortex.

Ballesteros-Yáñez, I., Benavides-Piccione, R., Elston, G.N., Yuste, R., DeFelipe, J.·2006·Neuroscience
DOI 10.1016/j.neuroscience.2005.11.038
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Abstract

Dendritic spines of pyramidal cells are the main postsynaptic targets of cortical excitatory synapses and as such, they are fundamental both in neuronal plasticity and for the integration of excitatory inputs to pyramidal neurons. There is significant variation in the number and density of dendritic spines among pyramidal cells located in different cortical areas and species, especially in primates. This variation is believed to contribute to functional differences reported among cortical areas. In this study, we analyzed the density of dendritic spines in the motor, somatosensory and visuo-temporal regions of the mouse cerebral cortex. Over 17,000 individual spines on the basal dendrites of layer III pyramidal neurons were drawn and their morphologies compared among these cortical regions. In contrast to previous observations in primates, there was no significant difference in the density of spines along the dendrites of neurons in the mouse. However, systematic differences in spine dimensions (spine head size and spine neck length) were detected, whereby the largest spines were found in the motor region, followed by those in the somatosensory region and those in visuo-temporal region.

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Crossref · 10.1016/j.neuroscience.2005.11.038

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  • The variation in spine density across neuronal populations likely reflects the diversity of neuronal morphology and function.

    “Spine density varies significantly across diverse populations of neurons, likely reflecting the diversity of neuronal morphology and function (Nimchinsky et al., 2002; Ballesteros-Yanez et al., 2006).”

    From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Ballesteros-Yanez et al., 2006

  • Spine density varies significantly across diverse populations of neurons.

    “Spine density varies significantly across diverse populations of neurons, likely reflecting the diversity of neuronal morphology and function (Nimchinsky et al., 2002; Ballesteros-Yanez et al., 2006).”

    From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Ballesteros-Yanez et al., 2006

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Authors
Ballesteros-Yáñez, I., Benavides-Piccione, R., Elston, G. N., Yuste, R., & DeFelipe, J.
Affiliations
  • The University of Queensland (AU)
  • Columbia University (US)
  • Consejo Superior de Investigaciones Científicas (ES)
Corresponding author
DeFelipe, J.
ORCID
Venue
Neuroscience
Publisher
Elsevier BV
Published
2006
Volume
138
Issue
2
Pages
403-409
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/j.neuroscience.2005.11.038
OpenAlex
W1972821200
Cited by
143
References
49
Citations by year
2026: 3 · 2025: 8 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 7 · 2018: 8 · 2017: 7 · 2016: 8 · 2015: 8 · 2014: 15 · 2013: 11 · 2012: 8
FWCI
2.27
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
dendritic spines, spine density, dendritic spine morphology, pyramidal neurons, layer III, mouse neocortex, motor cortex, somatosensory cortex, cortical regions, excitatory synapses, neuroplasticity
MeSH terms
Animals, Male, Mice, Inbred C57BL, Neuronal Plasticity, Pyramidal Cells, Neocortex, Dendritic Spines, Mice

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