Cited by 99Wnt/β-catenin signaling in development and cancerTGF-β signaling in diseasesDevelopmental Biology and Gene Regulation

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TGFβ and Wnt pathway cross-talk

Attisano, Liliana, Labbé, Etienne·2004·Cancer and Metastasis Reviews

DOI 10.1023/a:1025811012690

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Abstract

Transforming growth factor-betas (TGFbeta) and Wnts represent two distinct families of secreted molecules each of which utilizes different signaling pathways to elicit their biological effects. These factors regulate numerous developmental events and mutations in components of both pathways have been described in human cancers including colorectal carcinomas. Several studies have demonstrated that TGFbeta and Wnt ligands can cooperate to regulate differentiation and cell fate determination by controlling gene expression patterns. In addition, their cooperation in promoting tumorigenesis in mice has been described. Here, we focus on reviewing our current understanding of the molecular mechanisms that may mediate these cooperative effects.

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The Wnt/Ca2+ pathway
Kühl, M., Sheldahl, L. C., Park, M., Miller, J. R., & Moon, R. T. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(00)02028-x · Cited by 862
Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway
Mao, J., Wang, J., Liu, B., Pan, W., Farr, G. H., Flynn, C., Yuan, H., Takada, S., Kimelman, D., Li, L., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00224-6 · Cited by 839

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Bubb VJ, Curtis LJ, Cunningham C, Dunlop MG, Carothers AD, Morris RG, White S, Bird CC, Wyllie AH: Microsatellite instabilityand the role of hMSH2 in sporadic colorectal cancer. Oncogene 12: 2641–2649, 1996

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“…and both of the enriched signalling pathways, Wnt and Notch, have evolutionary conserved crosstalk with Tgfβ mediated signal in regulation of various molecular, cellular and developmental events (Attisano & Labbé 2004; Chesnutt et al. 2004; Arnold et al. 2019; Klüppel & Wrana 2005; Ahi 2016).”
Background
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Bhattacherjee, A. (2013) · KU ScholarWorks (The University of Kansas)
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Sun, J. (2010) · TSpace (University of Toronto)
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Edan, D. S. (2018) · Al Mustansiriyah Journal of Pharmaceutical Sciences · doi:10.32947/ajps.v17i1.56
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Tsai, S. L. (2019) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
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Pathway Crosstalk
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Banerjee, P., Sanyal, S., & Sen, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95735-9.00008-5
Transforming Growth Factor-β in Brain Functions and Dysfunctions
Vivien, D., Benchenane, K., & Ali, C. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-293-9_14
がん細胞多層オーミクス統合ネットワーク解析による遺伝子発現制御領域塩基変異の機能解析
Sereewattanawoot, S. (2020) · Institutional Repositories DataBase (IRDB) · doi:10.15083/0002005264

Authors: Attisano, L., & Labbé, E.
Affiliations: University of Toronto (CA)
Corresponding author: Attisano, Liliana
ORCID: Attisano, Liliana
Venue: Cancer and Metastasis Reviews
Publisher: Springer Science and Business Media LLC
Published: 2004-01
Volume: 23
Issue: 1-2
Pages: 53-61
ISSN: 0167-7659 (ISSN-L)
1573-7233
DOI: 10.1023/a:1025811012690
OpenAlex: W2055864323
Cited by: 98
References: 63
Citations by year: 2025: 4 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 8 · 2020: 2 · 2019: 3 · 2018: 6 · 2016: 8 · 2015: 1 · 2014: 2 · 2013: 6 · 2012: 9
FWCI: 0.31
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Cancer and Metastasis Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: TGF-beta signaling, Wnt signaling, pathway crosstalk, colorectal cancer, carcinogenesis, cell fate determination, cell differentiation, gene expression regulation
MeSH terms: Cell Differentiation, Humans, Ligands, Models, Biological, Proto-Oncogene Proteins, Colorectal Neoplasms, Signal Transduction, Gene Expression Regulation, Neoplastic, Transforming Growth Factor beta, Cell Lineage, Wnt Proteins

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TGFβ and Wnt pathway cross-talk

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