Cited by 99Wnt/β-catenin signaling in development and cancerTGF-β signaling in diseasesDevelopmental Biology and Gene Regulation

The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.

TGFβ and Wnt pathway cross-talk

Attisano, Liliana, Labbé, Etienne·2004·Cancer and Metastasis Reviews

DOI 10.1023/a:1025811012690

Open this paper in CoChat — free account

Abstract

Transforming growth factor-betas (TGFbeta) and Wnts represent two distinct families of secreted molecules each of which utilizes different signaling pathways to elicit their biological effects. These factors regulate numerous developmental events and mutations in components of both pathways have been described in human cancers including colorectal carcinomas. Several studies have demonstrated that TGFbeta and Wnt ligands can cooperate to regulate differentiation and cell fate determination by controlling gene expression patterns. In addition, their cooperation in promoting tumorigenesis in mice has been described. Here, we focus on reviewing our current understanding of the molecular mechanisms that may mediate these cooperative effects.

Integrity signals

Registry

Crossref · 10.1023/a:1025811012690

Cites

63 of 63 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Wnt signaling: a common theme in animal development
Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567
TGF-β Signaling in Tumor Suppression and Cancer Progression
Derynck, R., Akhurst, R. J., & Balmain, A. (2001) · Nature Genetics · doi:10.1038/ng1001-117 · Cited by 2,275
Signal Transduction by the TGF-β Superfamily
Attisano, L., & Wrana, J. L. (2002) · Science · doi:10.1126/science.1071809 · Cited by 1,286
Self-citation
Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism.
Bhowmick, N., Ghiassi, M., Bakin, A. V., Aakre, M., Lundquist, C., Engel, M., Arteaga, C., & Moses, H. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.1.27 · Cited by 1,087
Phosphatidylinositol 3-Kinase Function Is Required for Transforming Growth Factor β-mediated Epithelial to Mesenchymal Transition and Cell Migration
Bakin, A. V., Tomlinson, A. K., Bhowmick, N. A., Moses, H. L., & Arteaga, C. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005912200 · Cited by 1,008
SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor
Tsukazaki, T., Chiang, T., Davison, A. F., Attisano, L., & Wrana, J. L. (1998) · Cell · doi:10.1016/s0092-8674(00)81701-8 · Cited by 981
Self-citation
The Promise and Perils of Wnt Signaling Through β-Catenin
Moon, R. T., Bowerman, B. A., Boutros, M., & Perrimon, N. (2002) · Science · doi:10.1126/science.1071549 · Cited by 970
Smad regulation in TGF-β signal transduction
Moustakas, A., Souchelnytskyi, S., & Heldin, C. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.24.4359 · Cited by 937
The Wnt/Ca2+ pathway
Kühl, M., Sheldahl, L. C., Park, M., Miller, J. R., & Moon, R. T. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(00)02028-x · Cited by 862
Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway
Mao, J., Wang, J., Liu, B., Pan, W., Farr, G. H., Flynn, C., Yuan, H., Takada, S., Kimelman, D., Li, L., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00224-6 · Cited by 839
TGF-β signaling: positive and negative effects on tumorigenesis
Wakefield, L. M. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(01)00259-3 · Cited by 827
TGF‐β induces fibronectin synthesis through a c‐Jun N‐terminal kinase‐dependent, Smad4‐independent pathway
Hocevar, B. A., Brown, T. L., & Howe, P. H. (1999) · The EMBO Journal · doi:10.1093/emboj/18.5.1345 · Cited by 681
Requirement for β-Catenin in Anterior-Posterior Axis Formation in Mice
Huelsken, J., Vogel, R., Brinkmann, V., Erdmann, B., Birchmeier, C., & Birchmeier, W. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.3.567 · Cited by 655
TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice
Cui, W., Fowlis, D. J., Bryson, S., Duffie, E., Ireland, H., Balmain, A., & Akhurst, R. J. (1996) · Cell · doi:10.1016/s0092-8674(00)80127-0 · Cited by 628
TGF-β signaling by Smad proteins
Miyazono, K. (2000) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(99)00025-8 · Cited by 627
TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis
Oft, M., Heider, K., & Beug, H. (1998) · Current Biology · doi:10.1016/s0960-9822(07)00533-7 · Cited by 624
Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes
Takaku, K., Oshima, M., Miyoshi, H., Matsui, M., Seldin, M. F., & Taketo, M. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81132-0 · Cited by 616
TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction
Shibuyà, H., Yamaguchi, T., Shirakabe, K., Tonegawa, A., Gotoh, Y., Ueno, N., Irie, K., Nishida, E., & Matsumoto, K. (1996) · Science · doi:10.1126/science.272.5265.1179 · Cited by 587
New aspects of Wnt signaling pathways in higher vertebrates
Huelsken, J., & Birchmeier, W. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00231-8 · Cited by 561
Interdependent SMAD and JNK Signaling in Transforming Growth Factor-β-mediated Transcription
Engel, M. E., McDonnell, M. A., Law, B. K., & Moses, H. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.37413 · Cited by 538
The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryoPreprint
Sirard, C., de la Pompa, J. L., Elia, A., Itié, A., Mirtsos, C., Cheung, A., Hahn, S. A., Wakeham, A. C., Schwartz, L., Kern, S. E., et al. (1998) · Genes & Development · doi:10.1101/gad.12.1.107 · Cited by 498
Cripto is required for correct orientation of the anterior–posterior axis in the mouse embryo
Ding, J., Yang, L., Yan, Y., Chen, A. Y.-C., Desai, N., Wynshaw-Boris, A. J., & Shen, M. M. (1998) · Nature · doi:10.1038/27215 · Cited by 486
Interaction between Wnt and TGF-β signalling pathways during formation of Spemann's organizer
Nishita, M., Hashimoto, M. K., Ogata, S., Laurent, M. N., Ueno, N., Shibuyà, H., & Cho, K. W. Y. (2000) · Nature · doi:10.1038/35001602 · Cited by 466
LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic.
Riese, J., Yu, X., Munnerlyn, A., Eresh, S., Hsu, S.-C., Grosschedl, R., & Bienz, M. (1997) · Cell · doi:10.1016/s0092-8674(00)81924-8 · Cited by 465
Smad2 Signaling in Extraembryonic Tissues Determines Anterior-Posterior Polarity of the Early Mouse Embryo
Waldrip, W. R., Bikoff, E. K., Hoodless, P. A., Wrana, J. L., & Robertson, E. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81407-5 · Cited by 460
Regulation of cell proliferation by Smad proteins
ten Dijke, P., Goumans, M., Itoh, F., & Itoh, S. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10066 · Cited by 453
Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-β and Wnt pathways
Labbé, E., Letamendı́a, A., & Attisano, L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.150152697 · Cited by 442
Self-citation
Involvement of the p38 Mitogen-activated Protein Kinase Pathway in Transforming Growth Factor-β-induced Gene Expression
Hanafusa, H., Ninomiya‐Tsuji, J., Masuyama, N., Nishita, M., Fujisawa, J., Shibuyà, H., Matsumoto, K., & Nishida, E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.38.27161 · Cited by 441
Transforming Growth Factor-β–induced Mobilization of Actin Cytoskeleton Requires Signaling by Small GTPases Cdc42 and RhoA
Edlund, S., Landström, M., Heldin, C., & Aspenström, P. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-08-0398 · Cited by 418
A transcriptional response to Wnt protein in human embryonic carcinoma cells
Willert, J. R., Epping, M. T., Pollack, J. R., Brown, P. O., & Nusse, R. (2002) · BMC Developmental Biology · doi:10.1186/1471-213x-2-8 · Cited by 398
Signaling inputs converge on nuclear effectors in TGF-β signaling
ten Dijke, P., Miyazono, K., & Heldin, C. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01519-4 · Cited by 364
Role of Ras and Mapks in TGFβ signaling
Mulder, K. M. (2000) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(99)00026-x · Cited by 348
ATF-2 Is a Common Nuclear Target of Smad and TAK1 Pathways in Transforming Growth Factor-β Signaling
Sano, Y., Harada, J., Tashiro, S., Goto‐Mandeville, R., Maekawa, T., & Ishii, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.8949 · Cited by 344
Antagonistic Interactions Between Wingless and Decapentaplegic Responsible for Dorsal-Ventral Pattern in the Drosophila Leg
Brook, W. J., & Cohen, S. M. (1996) · Science · doi:10.1126/science.273.5280.1373 · Cited by 318
TGF-β induces assembly of a Smad2–Smurf2 ubiquitin ligase complex that targets SnoN for degradation
Bonni, S., Wang, H., Causing, C. G., Kavsak, P. A., Stroschein, S. L., Luo, K., & Wrana, J. L. (2001) · Nature Cell Biology · doi:10.1038/35078562 · Cited by 309
The Wnts.
Miller, J. R. (2001) · Genome biology · doi:10.1186/gb-2001-3-1-reviews3001 · Cited by 275
β-catenin, MAPK and Smad signaling during earlyXenopusdevelopment
Schohl, A., & Fagotto, F. (2002) · Development · doi:10.1242/dev.129.1.37 · Cited by 269
Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer
Li, Y., Hively, W. P., & Varmus, H. E. (2000) · Oncogene · doi:10.1038/sj.onc.1203273 · Cited by 254
Microsatellite instability and the role of hMSH2 in sporadic colorectalcancer.
Bubb, V., Curtis, L. J., Cunningham, C., Dunlop, M. G., Carothers, A. D., Rg, M., White, S., Bird, C. C., & Wyllie, A. H. (1996) · PubMed · Cited by 246
The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mousePreprint
Gu, Z., Nomura, M., Simpson, B. B., Lei, H., Feijen, A., Raaij, J. V. D. E.-V., Donahoe, P. K., & Li, E. (1998) · Genes & Development · doi:10.1101/gad.12.6.844 · Cited by 219
Wnt and Bmp signalling cooperatively regulate gradedEmx2 expression in the dorsal telencephalon
Theil, T., Aydin, S., Koch, S., Grotewold, L., & Rüther, U. (2002) · Development · doi:10.1242/dev.129.13.3045 · Cited by 189
Oncogenic beta-catenin is required for bone morphogenetic protein 4 expression in human cancer cells.
Kim, J.-S., Crooks, H., Dracheva, T., Nishanian, T. G., Singh, B., Jen, J., & Waldman, T. A. (2002) · PubMed · Cited by 181
Functions of mammalian Smad genes as revealed by targeted gene disruption in mice
Weinstein, M., Yang, X. Y., & Deng, C. (2000) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(99)00028-3 · Cited by 173
Anterior Endomesoderm Specification inXenopusby Wnt/β-catenin and TGF-β Signalling Pathways
Zorn, A. M., Butler, K., & Gurdon, J. B. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9257 · Cited by 170
The Smads.
Attisano, L., & Lee-Hoeflich, S. T. (2001) · Genome biology · doi:10.1186/gb-2001-2-8-reviews3010 · Cited by 166
Self-citation
Interactions between Wnt and Vg1 signalling pathways initiate primitive streak formation in the chick embryo
Skromne, I., & Stern, C. D. (2001) · Development · doi:10.1242/dev.128.15.2915 · Cited by 164
Axin Facilitates Smad3 Activation in the Transforming Growth Factor β Signaling Pathway
Furuhashi, M., Yagi, K., Yamamoto, H., Furukawa, Y., Shimada, S., Nakamura, Y., Kikuchi, A., Miyazono, K., & Kato, M. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.15.5132-5141.2001 · Cited by 163
Targeted Disruption in Murine Cells Reveals Variable Requirement for Smad4 in Transforming Growth Factor β-related Signaling
Sirard, C., Kim, S., Mirtsos, C., Tadich, P., Hoodless, P. A., Itié, A., Maxson, R. E., Wrana, J. L., & Mak, T. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.3.2063 · Cited by 161
Wnt-3A Enhances Bone Morphogenetic Protein-2-mediated Chondrogenesis of Murine C3H10T1/2 Mesenchymal Cells
Fischer, L. M., Boland, G. M., & Tuan, R. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109330200 · Cited by 154
The roles of three signaling pathways in the formation and function of the Spemann Organizer
Xanthos, J. B., Kofron, M. J., Tao, Q., Schaible, K., Wylie, C. C., & Heasman, J. (2002) · Development · doi:10.1242/dev.129.17.4027 · Cited by 131
Pattern formation in the visual centers of the Drosophila brain: wingless acts via decapentaplegic to specify the dorsoventral axis
Kaphingst, K. A., & Kunes, S. M. (1994) · Cell · doi:10.1016/0092-8674(94)90422-7 · Cited by 111
The Vestigial gene product provides a molecular context for the interpretation of signals during the development of the wing in Drosophila
Klein, T., & Arias, A. M. (1999) · Development · doi:10.1242/dev.126.5.913 · Cited by 111
Cooperation between the activin and Wnt pathways in the spatial control of organizer gene expression
Crease, D. J., Dyson, S., & Gurdon, J. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4398 · Cited by 101
Two different thresholds of wingless signalling with distinct developmental consequences in the Drosophila midgut.
Hoppler, S., & Bienz, M. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00184.x · Cited by 91
Compound disruption of smad2 accelerates malignant progression of intestinal tumors in apc knockout mice.
Hamamoto, T., Beppu, H., Okada, H., Kawabata, M., Kitamura, T., Miyazono, K., & Kato, M. (2002) · PubMed · Cited by 79
Wnt Signaling and Mammary Tumorigenesis
Smalley, M. J., & Dale, T. C. (2001) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1009564431268 · Cited by 71
Transforming growth factor-beta-induced growth inhibition in a Smad4 mutant colon adenoma cell line.
Fink, S. P., Swinler, S. E., Lutterbaugh, J., Massagué, J., Thiagalingam, S., Kinzler, K. W., Vogelstein, B., Willson, J. K. V., & Markowitz, S. D. (2001) · PubMed · Cited by 71
decapentaplegic, a target gene of the wingless signalling pathway in the Drosophila midgut
Yu, X., Hoppler, S., Eresh, S., & Bienz, M. (1996) · Development · doi:10.1242/dev.122.3.849 · Cited by 69
The Ballet of Morphogenesis
Peifer, M. A., & McEwen, D. G. (2002) · Cell · doi:10.1016/s0092-8674(02)00739-0 · Cited by 51
Synergistic Effects of Vg1 and Wnt Signals in the Specification of Dorsal Mesoderm and Endoderm
Cui, Y., Tian, Q., & Christian, J. L. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0281 · Cited by 50
No effects of Smad2 (madh2) null mutation on malignant progression of intestinal polyps in Apc(delta716) knockout mice.
Takaku, K., Wrana, J. L., Robertson, E. J., & Taketo, M. M. (2002) · PubMed · Cited by 28
Carcinogen-induced pancreatic lesions in the mouse: effect of Smad4 and Apc genotypes
Cullingworth, J., Hooper, M., Harrison, D. J., Mason, J. O., Sirard, C., Patek, C. E., & Clarke, A. R. (2002) · Oncogene · doi:10.1038/sj.onc.1205673 · Cited by 26
A New Smurf in the Village
Arora, K., & Warrior, R. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00067-3 · Cited by 25

Flagged first, then by citations

Research works printed but not linked: 1

Bubb VJ, Curtis LJ, Cunningham C, Dunlop MG, Carothers AD, Morris RG, White S, Bird CC, Wyllie AH: Microsatellite instabilityand the role of hMSH2 in sporadic colorectal cancer. Oncogene 12: 2641–2649, 1996

Sorted by citations

Signaling cross-talk between TGF-β/BMP and other pathways
Guo, X., & Wang, X. (2008) · Cell Research · doi:10.1038/cr.2008.302 · Cited by 1,077
Specificity, versatility, and control of TGF-β family signaling
Derynck, R., & Budi, E. H. (2019) · Science Signaling · doi:10.1126/scisignal.aav5183 · Cited by 785
Signaling Cross Talk between TGF-β/Smad and Other Signaling PathwaysPreprint
Luo, K. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022137 · Cited by 671
Axin is a scaffold protein in TGF‐β signaling that promotes degradation of Smad7 by Arkadia
Liu, W., Rui, H., Wang, J., Lin, S., He, Y., Chen, M., Li, Q., Ye, Z., Chan, S. C., Chan, S. C., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601057 · Cited by 199
Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness
Avgustinova, A., Iravani, M., Robertson, D., Fearns, A., Gao, Q., Klingbeil, P., Hanby, A. M., Speirs, V., Sahai, E., Calvo, F., et al. (2016) · Nature Communications · doi:10.1038/ncomms10305 · Cited by 180

See all 99

Authors: Attisano, L., & Labbé, E.
Affiliations: University of Toronto (CA)
Corresponding author: Attisano, Liliana
ORCID: Attisano, Liliana
Venue: Cancer and Metastasis Reviews
Publisher: Springer Science and Business Media LLC
Published: 2004-01
Volume: 23
Issue: 1-2
Pages: 53-61
ISSN: 0167-7659 (ISSN-L)
1573-7233
DOI: 10.1023/a:1025811012690
OpenAlex: W2055864323
Cited by: 98
References: 63
Citations by year: 2025: 4 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 8 · 2020: 2 · 2019: 3 · 2018: 6 · 2016: 8 · 2015: 1 · 2014: 2 · 2013: 6 · 2012: 9
FWCI: 0.31
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Cancer and Metastasis Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: TGF-beta signaling, Wnt signaling, pathway crosstalk, colorectal cancer, carcinogenesis, cell fate determination, cell differentiation, gene expression regulation
MeSH terms: Cell Differentiation, Humans, Ligands, Models, Biological, Proto-Oncogene Proteins, Colorectal Neoplasms, Signal Transduction, Gene Expression Regulation, Neoplastic, Transforming Growth Factor beta, Cell Lineage, Wnt Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

TGFβ and Wnt pathway cross-talk

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks