The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
TGFβ and Wnt pathway cross-talk
Abstract
Transforming growth factor-betas (TGFbeta) and Wnts represent two distinct families of secreted molecules each of which utilizes different signaling pathways to elicit their biological effects. These factors regulate numerous developmental events and mutations in components of both pathways have been described in human cancers including colorectal carcinomas. Several studies have demonstrated that TGFbeta and Wnt ligands can cooperate to regulate differentiation and cell fate determination by controlling gene expression patterns. In addition, their cooperation in promoting tumorigenesis in mice has been described. Here, we focus on reviewing our current understanding of the molecular mechanisms that may mediate these cooperative effects.
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“both of the enriched signalling pathways, Wnt and Notch, have evolutionary conserved crosstalk with Tgfβ mediated signal in regulation of various molecular, cellular and developmental events (Attisano & Labbé 2004; Chesnutt et al. 2004; Arnold et al. 2019; Klüppel & Wrana 2005; Ahi 2016).”
From Parallel molecular mechanisms underlie convergent evolution of the exaggerated snout phenotype in East African cichlids (2022) · cites this paper as Attisano & Labbé 2004
Citations
Cites
Wnt signaling: a common theme in animal development
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TGF-β Signaling in Tumor Suppression and Cancer Progression
Derynck, R., Akhurst, R. J., & Balmain, A. (2001) · Nature Genetics · doi:10.1038/ng1001-117 · Cited by 2,275
Signal Transduction by the TGF-β Superfamily
Attisano, L., & Wrana, J. L. (2002) · Science · doi:10.1126/science.1071809 · Cited by 1,286
Self-citationBhowmick, N., Ghiassi, M., Bakin, A. V., Aakre, M., Lundquist, C., Engel, M., Arteaga, C., & Moses, H. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.1.27 · Cited by 1,087
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SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor
Tsukazaki, T., Chiang, T., Davison, A. F., Attisano, L., & Wrana, J. L. (1998) · Cell · doi:10.1016/s0092-8674(00)81701-8 · Cited by 981
Self-citationThe Promise and Perils of Wnt Signaling Through β-Catenin
Moon, R. T., Bowerman, B. A., Boutros, M., & Perrimon, N. (2002) · Science · doi:10.1126/science.1071549 · Cited by 970
Smad regulation in TGF-β signal transduction
Moustakas, A., Souchelnytskyi, S., & Heldin, C. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.24.4359 · Cited by 937
Kühl, M., Sheldahl, L. C., Park, M., Miller, J. R., & Moon, R. T. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(00)02028-x · Cited by 862
Mao, J., Wang, J., Liu, B., Pan, W., Farr, G. H., Flynn, C., Yuan, H., Takada, S., Kimelman, D., Li, L., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00224-6 · Cited by 839
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Research works printed but not linked: 1
- Bubb VJ, Curtis LJ, Cunningham C, Dunlop MG, Carothers AD, Morris RG, White S, Bird CC, Wyllie AH: Microsatellite instabilityand the role of hMSH2 in sporadic colorectal cancer. Oncogene 12: 2641–2649, 1996
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Signaling cross-talk between TGF-β/BMP and other pathways
Guo, X., & Wang, X. (2008) · Cell Research · doi:10.1038/cr.2008.302 · Cited by 1,077
Specificity, versatility, and control of TGF-β family signaling
Derynck, R., & Budi, E. H. (2019) · Science Signaling · doi:10.1126/scisignal.aav5183 · Cited by 785
Signaling Cross Talk between TGF-β/Smad and Other Signaling PathwaysPreprint
Luo, K. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022137 · Cited by 671
Axin is a scaffold protein in TGF‐β signaling that promotes degradation of Smad7 by Arkadia
Liu, W., Rui, H., Wang, J., Lin, S., He, Y., Chen, M., Li, Q., Ye, Z., Chan, S. C., Chan, S. C., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601057 · Cited by 199
Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness
Avgustinova, A., Iravani, M., Robertson, D., Fearns, A., Gao, Q., Klingbeil, P., Hanby, A. M., Speirs, V., Sahai, E., Calvo, F., et al. (2016) · Nature Communications · doi:10.1038/ncomms10305 · Cited by 180
Metadata
- Authors
- Attisano, L., & Labbé, E.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Attisano, Liliana
- ORCID
- Attisano, Liliana
- Venue
- Cancer and Metastasis Reviews
- Published
- 2004-01
- Volume
- 23
- Issue
- 1-2
- Pages
- 53-61
- ISSN
- 0167-7659 (ISSN-L)
- 1573-7233
- OpenAlex
- W2055864323
- Cited by
- 98
- References
- 63
- Citations by year
- 2025: 4 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 8 · 2020: 2 · 2019: 3 · 2018: 6 · 2016: 8 · 2015: 1 · 2014: 2 · 2013: 6 · 2012: 9
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Cancer and Metastasis Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- TGF-beta signaling, Wnt signaling, pathway crosstalk, colorectal cancer, carcinogenesis, cell fate determination, cell differentiation, gene expression regulation
- MeSH terms
- Cell Differentiation, Humans, Ligands, Models, Biological, Proto-Oncogene Proteins, Colorectal Neoplasms, Signal Transduction, Gene Expression Regulation, Neoplastic, Transforming Growth Factor beta, Cell Lineage, Wnt Proteins
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