Cited by 209Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene RegulationCancer Cells and Metastasis

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β-Catenin and Tcfs in Mammary Development and Cancer

Hatsell, Sarah, Rowlands, Tracey, Hiremath, Minoti, Cowin, Pamela·2003·Journal of Mammary Gland Biology and Neoplasia

DOI 10.1023/a:1025944723047

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Abstract

Beta-catenin regulates cell-cell adhesion and transduces signals from many pathways to regulate the transcriptional activities of Tcf/Lef DNA binding factors. Gene ablation and transgenic expression studies strongly support the concept that beta-catenin together with Lef/Tcf factors act as a switch to determine cell fate and promote cell survival and proliferation at several stages during mammary gland development. Mice expressing the negative regulator of Wnt/beta-catenin signaling (K14-Dkk) fail to form mammary buds, and those lacking Lef-1 show an early arrest in this process at stage E13.5. Stabilized deltaN89beta-catenin initiates precocious alveologenesis during pubertal development, and negative regulators of endogenous beta-catenin signaling suppress normal alveologenesis during pregnancy. Stabilized beta-catenin induces hyperplasia and mammary tumors in mice. Each of the beta-catenin-induced phenotypes is accompanied by upregulation of the target genes cyclin D1 and c-myc. Cyclin D1, however, is dispensable for tumor formation and the initiation of alveologenesis but is essential for later alveolar expansion.

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See all 209

Authors: Hatsell, S., Rowlands, T., Hiremath, M., & Cowin, P.
Affiliations: New York University (US)
Corresponding author: Cowin, Pamela
ORCID: Hatsell, Sarah
Cowin, Pamela
Venue: Journal of Mammary Gland Biology and Neoplasia
Publisher: Springer Science and Business Media LLC
Published: 2003-04
Volume: 8
Issue: 2
Pages: 145-158
ISSN: 1083-3021 (ISSN-L)
1573-7039
DOI: 10.1023/a:1025944723047
OpenAlex: W1520332974
Cited by: 209
References: 93
Citations by year: 2025: 2 · 2024: 9 · 2023: 7 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 8 · 2018: 5 · 2017: 11 · 2016: 3 · 2015: 14 · 2014: 10 · 2013: 7 · 2012: 10
FWCI: 1.09
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Journal of Mammary Gland Biology and Neoplasia (publishedVersion)
PubMed (publishedVersion)
Funders: Health Research Board
National Institute for Health and Care Research
National Institutes of Health
National Institute of General Medical Sciences (GM 47429, R01GM047429)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords: β-catenin, TCF/LEF transcription factors, mammary gland development, breast cancer, Wnt/β-catenin signaling, alveolarization, cyclin D1, c-Myc, cell fate determination, mammary gland hyperplasia, LEF1, alveolar expansion
MeSH terms: Animals, Breast Neoplasms, Cell Adhesion, Cell Division, Cell Survival, Cytoskeletal Proteins, DNA-Binding Proteins, Female, Humans, Mammary Glands, Animal, Models, Biological, Phenotype, Transcription Factors, Signal Transduction, Trans-Activators, Mammary Neoplasms, Animal, Cadherins, Up-Regulation, Proto-Oncogene Proteins c-myc, Mucin-1, Cyclin D1, Mammary Glands, Human, beta Catenin, Mice, Lymphoid Enhancer-Binding Factor 1

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β-Catenin and Tcfs in Mammary Development and Cancer

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