The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
β-Catenin and Tcfs in Mammary Development and Cancer
Abstract
Beta-catenin regulates cell-cell adhesion and transduces signals from many pathways to regulate the transcriptional activities of Tcf/Lef DNA binding factors. Gene ablation and transgenic expression studies strongly support the concept that beta-catenin together with Lef/Tcf factors act as a switch to determine cell fate and promote cell survival and proliferation at several stages during mammary gland development. Mice expressing the negative regulator of Wnt/beta-catenin signaling (K14-Dkk) fail to form mammary buds, and those lacking Lef-1 show an early arrest in this process at stage E13.5. Stabilized deltaN89beta-catenin initiates precocious alveologenesis during pubertal development, and negative regulators of endogenous beta-catenin signaling suppress normal alveologenesis during pregnancy. Stabilized beta-catenin induces hyperplasia and mammary tumors in mice. Each of the beta-catenin-induced phenotypes is accompanied by upregulation of the target genes cyclin D1 and c-myc. Cyclin D1, however, is dispensable for tumor formation and the initiation of alveologenesis but is essential for later alveolar expansion.
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“Once Dsh is activated, it inhibits the activity of the GSK3 enzyme, and activates a complex series of events that lead to the prevention of degradation of β-catenin and its consequent stabilization and accumulation in the cytoplasm.42”
From Wnt signal transduction pathways (2008) · cites this paper as [42]
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Cites
1 retracted
Chan, S.-K., & Struhl, G. (2002) · Cell · doi:10.1016/s0092-8674(02)01037-1 · Cited by 58
RetractedIdentification of c- MYC as a Target of the APC Pathway
He, T.-C., Sparks, A. B., Rago, C., Hermeking, H., Zawel, L., da Costa, L. T., Morin, P. J., Vogelstein, B., & Kinzler, K. W. (1998) · Science · doi:10.1126/science.281.5382.1509 · Cited by 4,566
β-Catenin regulates expression of cyclin D1 in colon carcinoma cells
Tetsu, O., & McCormick, F. (1999) · Nature · doi:10.1038/18884 · Cited by 3,601
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma
Korinek, V., Barker, N., Morin, P. J., van Wichen, D., de Weger, R., Kinzler, K. W., Vogelstein, B., & Clevers, H. (1997) · Science · doi:10.1126/science.275.5307.1784 · Cited by 2,905
The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway
Shtutman, M., Zhurinsky, J., Simcha, I., Albanese, C., D’Amico, M., Pestell, R., & Ben-Ze’ev, A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5522 · Cited by 2,230
Ozawa, M., Baribault, H., & Kemler, R. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03563.x · Cited by 1,396
β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G., & Birchmeier, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00336-1 · Cited by 1,352
Directed Actin Polymerization Is the Driving Force for Epithelial Cell–Cell Adhesion
Vasioukhin, V., Bauer, C., Yin, M., & Fuchs, E. (2000) · Cell · doi:10.1016/s0092-8674(00)81559-7 · Cited by 1,205
De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin
Gat, U., DasGupta, R., Degenstein, L., & Fuchs, E. (1998) · Cell · doi:10.1016/s0092-8674(00)81631-1 · Cited by 1,089
Cyclin D1 provides a link between development and oncogenesis in the retina and breast
Sicinski, P., Donaher, J. L., Parker, S. B., Li, T., Fazeli, A., Gardner, H., Haslam, S. Z., Bronson, R. T., Elledge, S. J., & Weinberg, R. A. (1995) · Cell · doi:10.1016/0092-8674(95)90034-9 · Cited by 1,021
Research works printed but not linked: 3
- R. Eelkema and P. Cowin (2001). General themes in cell-cell junctions and adhesion. In M. Cereijido, and J. Anderson (eds.), Tight Junctions, Vol. 2, CRC Press, Boca Raton, pp. 121–145.
- J. Sap Interactions between protein tyrosine phosphatases and cell adhesion molecules. In P. Cowinand and M. Klymkowsky (eds.), Cytoskeletal-Membrane Interactions and Signal Transduction, Landes, Austin, (1997).
- S. Millar (1997). The role of patterning genes in epidermal differentiation. In P. Cowin and M. Klymkowsky (eds.), Cytoskeletal-Membrane Interactions and Signal Transduction, Landes, Austin, pp. 87–103.
Cited by
Sorted by citations
Wnt signal transduction pathways
Komiya, Y., & Habas, R. (2008) · Organogenesis · doi:10.4161/org.4.2.5851 · Cited by 1,528
Minireview: Cyclin D1: Normal and Abnormal Functions
Fu, M., Wang, C., Li, Z., Sakamaki, T., & Pestell, R. G. (2004) · Endocrinology · doi:10.1210/en.2004-0959 · Cited by 961
Wnt/β-Catenin Pathway Activation Is Enriched in Basal-Like Breast Cancers and Predicts Poor Outcome
Khramtsov, A., Khramtsova, G. F., Tretiakova, M., Huo, D., Olopade, O. I., & Goss, K. H. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.091125 · Cited by 509
Leong, K. G., Niessen, K. S., Kulić, I., Raouf, A., Eaves, C. J., Pollet, I. L., & Karsan, A. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071082 · Cited by 473
Kufe, D. W. (2012) · Oncogene · doi:10.1038/onc.2012.158 · Cited by 452
Metadata
- Authors
- Hatsell, S., Rowlands, T., Hiremath, M., & Cowin, P.
- Affiliations
- New York University (US)
- Corresponding author
- Cowin, Pamela
- Venue
- Journal of Mammary Gland Biology and Neoplasia
- Published
- 2003-04
- Volume
- 8
- Issue
- 2
- Pages
- 145-158
- ISSN
- 1083-3021 (ISSN-L)
- 1573-7039
- OpenAlex
- W1520332974
- Cited by
- 209
- References
- 93
- Citations by year
- 2025: 2 · 2024: 9 · 2023: 7 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 8 · 2018: 5 · 2017: 11 · 2016: 3 · 2015: 14 · 2014: 10 · 2013: 7 · 2012: 10
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Mammary Gland Biology and Neoplasia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Health Research Board
- National Institute for Health and Care Research
- National Institutes of Health
- National Institute of General Medical Sciences (GM 47429, R01GM047429)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- β-catenin, TCF/LEF transcription factors, mammary gland development, breast cancer, Wnt/β-catenin signaling, alveolarization, cyclin D1, c-Myc, cell fate determination, mammary gland hyperplasia, LEF1, alveolar expansion
- MeSH terms
- Animals, Breast Neoplasms, Cell Adhesion, Cell Division, Cell Survival, Cytoskeletal Proteins, DNA-Binding Proteins, Female, Humans, Mammary Glands, Animal, Models, Biological, Phenotype, Transcription Factors, Signal Transduction, Trans-Activators, Mammary Neoplasms, Animal, Cadherins, Up-Regulation, Proto-Oncogene Proteins c-myc, Mucin-1, Cyclin D1, Mammary Glands, Human, beta Catenin, Mice, Lymphoid Enhancer-Binding Factor 1
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