Cited by 209Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene RegulationCancer Cells and Metastasis

The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.

β-Catenin and Tcfs in Mammary Development and Cancer

Hatsell, Sarah, Rowlands, Tracey, Hiremath, Minoti, Cowin, Pamela·2003·Journal of Mammary Gland Biology and Neoplasia

DOI 10.1023/a:1025944723047

Open this paper in CoChat — free account

Abstract

Beta-catenin regulates cell-cell adhesion and transduces signals from many pathways to regulate the transcriptional activities of Tcf/Lef DNA binding factors. Gene ablation and transgenic expression studies strongly support the concept that beta-catenin together with Lef/Tcf factors act as a switch to determine cell fate and promote cell survival and proliferation at several stages during mammary gland development. Mice expressing the negative regulator of Wnt/beta-catenin signaling (K14-Dkk) fail to form mammary buds, and those lacking Lef-1 show an early arrest in this process at stage E13.5. Stabilized deltaN89beta-catenin initiates precocious alveologenesis during pubertal development, and negative regulators of endogenous beta-catenin signaling suppress normal alveologenesis during pregnancy. Stabilized beta-catenin induces hyperplasia and mammary tumors in mice. Each of the beta-catenin-induced phenotypes is accompanied by upregulation of the target genes cyclin D1 and c-myc. Cyclin D1, however, is dispensable for tumor formation and the initiation of alveologenesis but is essential for later alveolar expansion.

Integrity signals

Registry

Crossref · 10.1023/a:1025944723047

Cites

93 of 93 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Evidence that Armadillo Transduces Wingless by Mediating Nuclear Export or Cytosolic Activation of Pangolin
Chan, S.-K., & Struhl, G. (2002) · Cell · doi:10.1016/s0092-8674(02)01037-1 · Cited by 58
Retracted
Identification of c- MYC as a Target of the APC Pathway
He, T.-C., Sparks, A. B., Rago, C., Hermeking, H., Zawel, L., da Costa, L. T., Morin, P. J., Vogelstein, B., & Kinzler, K. W. (1998) · Science · doi:10.1126/science.281.5382.1509 · Cited by 4,566
β-Catenin regulates expression of cyclin D1 in colon carcinoma cells
Tetsu, O., & McCormick, F. (1999) · Nature · doi:10.1038/18884 · Cited by 3,601
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma
Korinek, V., Barker, N., Morin, P. J., van Wichen, D., de Weger, R., Kinzler, K. W., Vogelstein, B., & Clevers, H. (1997) · Science · doi:10.1126/science.275.5307.1784 · Cited by 2,905
The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway
Shtutman, M., Zhurinsky, J., Simcha, I., Albanese, C., D’Amico, M., Pestell, R., & Ben-Ze’ev, A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5522 · Cited by 2,230
The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.
Ozawa, M., Baribault, H., & Kemler, R. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03563.x · Cited by 1,396
β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G., & Birchmeier, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00336-1 · Cited by 1,352
Directed Actin Polymerization Is the Driving Force for Epithelial Cell–Cell Adhesion
Vasioukhin, V., Bauer, C., Yin, M., & Fuchs, E. (2000) · Cell · doi:10.1016/s0092-8674(00)81559-7 · Cited by 1,205
De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin
Gat, U., DasGupta, R., Degenstein, L., & Fuchs, E. (1998) · Cell · doi:10.1016/s0092-8674(00)81631-1 · Cited by 1,089
Cyclin D1 provides a link between development and oncogenesis in the retina and breast
Sicinski, P., Donaher, J. L., Parker, S. B., Li, T., Fazeli, A., Gardner, H., Haslam, S. Z., Bronson, R. T., Elledge, S. J., & Weinberg, R. A. (1995) · Cell · doi:10.1016/0092-8674(95)90034-9 · Cited by 1,021

Show all 93 references

Research works printed but not linked: 3

R. Eelkema and P. Cowin (2001). General themes in cell-cell junctions and adhesion. In M. Cereijido, and J. Anderson (eds.), Tight Junctions, Vol. 2, CRC Press, Boca Raton, pp. 121–145.
J. Sap Interactions between protein tyrosine phosphatases and cell adhesion molecules. In P. Cowinand and M. Klymkowsky (eds.), Cytoskeletal-Membrane Interactions and Signal Transduction, Landes, Austin, (1997).
S. Millar (1997). The role of patterning genes in epidermal differentiation. In P. Cowin and M. Klymkowsky (eds.), Cytoskeletal-Membrane Interactions and Signal Transduction, Landes, Austin, pp. 87–103.

Sorted by citations

Wnt signal transduction pathways
Komiya, Y., & Habas, R. (2008) · Organogenesis · doi:10.4161/org.4.2.5851 · Cited by 1,528
Minireview: Cyclin D1: Normal and Abnormal Functions
Fu, M., Wang, C., Li, Z., Sakamaki, T., & Pestell, R. G. (2004) · Endocrinology · doi:10.1210/en.2004-0959 · Cited by 961
Wnt/β-Catenin Pathway Activation Is Enriched in Basal-Like Breast Cancers and Predicts Poor Outcome
Khramtsov, A., Khramtsova, G. F., Tretiakova, M., Huo, D., Olopade, O. I., & Goss, K. H. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.091125 · Cited by 509
Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin
Leong, K. G., Niessen, K. S., Kulić, I., Raouf, A., Eaves, C. J., Pollet, I. L., & Karsan, A. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071082 · Cited by 473
MUC1-C oncoprotein as a target in breast cancer: activation of signaling pathways and therapeutic approaches
Kufe, D. W. (2012) · Oncogene · doi:10.1038/onc.2012.158 · Cited by 452
β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation
Geyer, F. C., Lacroix‐Triki, M., Savage, K., Arnedos, M., Lambros, M. B. K., Mackay, A. G., Natrajan, R., & Reis-Filho, J. S. (2010) · Modern Pathology · doi:10.1038/modpathol.2010.205 · Cited by 373
Integration of Estrogen and Wnt Signaling Circuits by the Polycomb Group Protein EZH2 in Breast Cancer Cells
Shi, B., Liang, J., Yang, X., Wang, Y., Zhao, Y., Wu, H., Sun, L., Zhang, Y., Chen, Y., Li, R., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00162-07 · Cited by 355
Liver stem cells and hepatocellular carcinoma†
Mishra, L., Banker, T. P., Murray, J. C., Byers, S. W., Thenappan, A., He, A. R., Shetty, K., Johnson, L. B., & Reddy, E. P. (2008) · Hepatology · doi:10.1002/hep.22704 · Cited by 339
Biomarkers of Epithelial-Mesenchymal Transition in Squamous Cell Carcinoma
Scanlon, C. S., Tubergen, E. A. V., Inglehart, R. C., & D’Silva, N. J. (2012) · Journal of Dental Research · doi:10.1177/0022034512467352 · Cited by 331
Twist Overexpression Induces In vivo Angiogenesis and Correlates with Chromosomal Instability in Breast Cancer
Mironchik, Y., Winnard, P. T., Vesuna, F., Katō, Y., Wildes, F. B., Pathak, A. P., Kominsky, S. L., Artemov, D., Bhujwalla, Z. M., van Diest, P. J., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0712 · Cited by 274
On mammary stem cells
Woodward, W. A., Chen, M. S., Behbod, F., & Rosen, J. M. (2005) · Journal of Cell Science · doi:10.1242/jcs.02532 · Cited by 282
Adiponectin Modulates the Glycogen Synthase Kinase-3β/β-Catenin Signaling Pathway and Attenuates Mammary Tumorigenesis of MDA-MB-231 Cells in Nude Mice
Wang, Y., Lam, J. B. B., Lam, K. S. L., Liu, J., Lam, M. C., Hoo, R. L. C., Wu, D., Cooper, G. J. S., & Xu, A. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1969 · Cited by 270
Wnt Signalling in Implantation, Decidualisation and Placental Differentiation – Review
Sonderegger, S., Pollheimer, J., & Knöfler, M. (2010) · Placenta · doi:10.1016/j.placenta.2010.07.011 · Cited by 271
Tamoxifen resistance in MCF7 cells promotes EMT-like behaviour and involves modulation of β-catenin phosphorylation
Hiscox, S., Jiang, W. G., Obermeier, K., Taylor, K. M., Morgan, L. D., Burmi, R. S., Barrow, D., & Nicholson, R. I. (2005) · International Journal of Cancer · doi:10.1002/ijc.21355 · Cited by 259
Wnt Proteins in Mammary Development and Cancer
Brennan, K. R., & Brown, A. M. C. (2004) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/b:jomg.0000037157.94207.33 · Cited by 247
Candidate regulators of mammary branching morphogenesis identified by genome‐wide transcript analysis
Kouros‐Mehr, H., & Werb, Z. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20978 · Cited by 220
Quantitative In situ Analysis of β-Catenin Expression in Breast Cancer Shows Decreased Expression Is Associated with Poor Outcome
Dolled-Filhart, M. P., McCabe, A., Giltnane, J. M., Cregger, M. A., Camp, R. L., & Rimm, D. L. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0100 · Cited by 181
The regulation and role of osteopontin in malignant transformation and cancer
El‐Tanani, M., Campbell, F. C., Kurisetty, V., Jin, D.-C., MCCANN, M., & Rudland, P. S. (2006) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2006.09.010 · Cited by 174
Genetic Changes of Wnt Pathway Genes Are Common Events in Metaplastic Carcinomas of the Breast
Hayes, M. J., Thomas, D. G., Emmons, A., Giordano, T. J., & Kleer, C. G. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4379 · Cited by 174
β-catenin up-regulates the expression of cyclinD1, c-myc and MMP-7 in human pancreatic cancer: Relationships with carcinogenesis and metastasis
Li, Y. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i14.2117 · Cited by 160
Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways
Weivoda, M. M., Ruan, M. M., Hachfeld, C. M., Pederson, L. G., Howe, A. K., Davey, R. A., Zajac, J. D., Kobayashi, Y., Williams, B. O., Westendorf, J. J., et al. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2599 · Cited by 157
Placental Cadherin and the Basal Epithelial Phenotype of BRCA1-Related Breast Cancer
Arnes, J. B., Brunet, J., Stefansson, I. M., Bégin, L. R., Wong, N., Chappuis, P. O., Akslen, L. A., & Foulkes, W. D. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2064 · Cited by 161
Key stages in mammary gland development - The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium
Oakes, S. R., Hilton, H. N., & Ormandy, C. J. (2006) · Breast Cancer Research · doi:10.1186/bcr1411 · Cited by 159
Kinase-Inactive Glycogen Synthase Kinase 3β Promotes Wnt Signaling and Mammary Tumorigenesis
Farago, M., Dominguez, I. M., Landesman‐Bollag, E., Xu, X., Rosner, A., Cardiff, R. D., & Seldin, D. C. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1021 · Cited by 151
Cytoplasmic Localization of β-Catenin is a Marker of Poor Outcome in Breast Cancer Patients
López‐Knowles, E., Zardawi, S. J., McNeil, C. M., Millar, E. K. A., Crea, P., Musgrove, E. A., Sutherland, R. L., & O'Toole, S. A. (2010) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-09-0741 · Cited by 150
Wnt-5a/Ca2+-Induced NFAT Activity Is Counteracted by Wnt-5a/Yes-Cdc42-Casein Kinase 1α Signaling in Human Mammary Epithelial Cells
Dejmek, J. S., Säfholm, A., Nielsen, C. K., Andersson, T., & Leandersson, K. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02354-05 · Cited by 145
A Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone Ingredient
Sun, H., Luo, G., Chen, D., & Xiang, Z. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00247 · Cited by 142
β-catenin/Wnt signalling pathway in fibromatosis, metaplastic carcinomas and phyllodes tumours of the breast
Lacroix‐Triki, M., Geyer, F. C., Lambros, M. B. K., Savage, K., Ellis, I. O., Lee, A. H. S., & Reis-Filho, J. S. (2010) · Modern Pathology · doi:10.1038/modpathol.2010.141 · Cited by 133
The role of Wnt signaling members in the uterus and embryo during pre-implantation and implantation
Tepeköy, F., Akkoyunlu, G., & Demir, R. (2014) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-014-0409-7 · Cited by 130
Human Papillomaviruses as Infectious Agents in Gynecological Cancers. Oncogenic Properties of Viral Proteins
Haręża, D. A., Wilczyński, J. R., & Paradowska, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031818 · Cited by 127
Anoikis resistance––protagonists of breast cancer cells survive and metastasize after ECM detachment
Dai, Y., Zhang, X., Ou, Y., Zou, L., Zhang, D., Yang, Q., Qin, Y., Du, X., Li, W., Yuan, Z., et al. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01183-4 · Cited by 126
Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer
McSherry, E. A., Donatello, S., Hopkins, A. M., & McDonnell, S. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7388-0 · Cited by 124
Dysregulation of Hedgehog, Wnt and Notch signalling pathways in breast cancer.
Zardawi, S. J., O'Toole, S. A., Sutherland, R. L., & Musgrove, E. A. (2009) · PubMed · doi:10.14670/hh-24.385 · Cited by 111
Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer
Shulewitz, M. J., Soloviev, I., Wu, T., Koeppen, H., Polakis, P. G., & Sakanaka, C. (2006) · Oncogene · doi:10.1038/sj.onc.1209470 · Cited by 111
Adhesion in Mammary Development
Shamir, E. R., & Ewald, A. J. (2015) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2014.12.001 · Cited by 109
Signaling pathways in HPV‐associated cancers and therapeutic implications
Chen, J. (2015) · Reviews in Medical Virology · doi:10.1002/rmv.1823 · Cited by 108
Cyclin D1 Is Not an Immediate Target of β-Catenin following Apc Loss in the Intestine
Sansom, O. J., Reed, K. R., van de Wetering, M., Muncan, V., Winton, D. J., Clevers, H. C., & Clarke, A. R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500191200 · Cited by 105
Slit-2 Induces a Tumor-suppressive Effect by Regulating β-Catenin in Breast Cancer Cells
Prasad, A., Paruchuri, V., Preet, A., Latif, F., & Ganju, R. K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800679200 · Cited by 104
Canonical Wnt signaling negatively regulates branching morphogenesis of the lung and lacrimal gland
Dean, C. H., Miller, L. D., Smith, A. N., Dufort, D., Lang, R. A., & Niswander, L. A. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.07.034 · Cited by 103
Effect of Obesity on Breast Cancer Development
Cleary, M. P., Grossmann, M. E., & Ray, A. (2010) · Veterinary Pathology · doi:10.1177/0300985809357753 · Cited by 99
β-Catenin overexpression in malignant glioma and its role in proliferation and apoptosis in glioblastma cells
Liu, X., Wang, L., Zhao, S., Ji, X., Luo, Y., & Ling, F. (2010) · Medical Oncology · doi:10.1007/s12032-010-9476-5 · Cited by 98
Gene expression analysis of B‐lymphoma cells resistant and sensitive to bortezomib*
Shringarpure, R., Catley, L. P., Bhole, D., Burger, R., Podar, K., Tai, Y., Kessler, B. M., Galardy, P. J., Ploegh, H. L., Tassone, P., et al. (2006) · British Journal of Haematology · doi:10.1111/j.1365-2141.2006.06132.x · Cited by 99
Epigenetic inactivation of the secreted frizzled-related protein-5 ( SFRP5 ) gene in human breast cancer is associated with unfavorable prognosis
Veeck, J., Geisler, C., Noetzel, E., Alkaya, S., Hartmann, A., Knüchel, R., & Dahl, E. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn076 · Cited by 96
Piperine suppresses the Wnt/β-catenin pathway and has anti-cancer effects on colorectal cancer cells
de Almeida, G. C., Oliveira, L. F. S., Predes, D., Fokoue, H. H., Kuster, R. M., de Oliveira, F. L., Mendes, F. A., & Abreu, J. G. (2020) · Scientific Reports · doi:10.1038/s41598-020-68574-2 · Cited by 93
Wnt-5a mRNA translation is suppressed by the Elav-like protein HuR in human breast epithelial cells
Leandersson, K., Riesbeck, K., & Andersson, T. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl571 · Cited by 92
Effects of EpCAM overexpression on human breast cancer cell lines
Gostner, J. M., Fong, D., Wrulich, O. A., Lehne, F., Zitt, M., Hermann, M., Krobitsch, S., Martowicz, A., Gastl, G. A., & Spizzo, G. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-45 · Cited by 89
RETRACTED ARTICLE: Molecular mechanisms in progression of HPV-associated cervical carcinogenesis
Gupta, S. M., & Mania‐Pramanik, J. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0520-2 · Cited by 91
Retracted
Cadherins and the mammary gland
Knudsen, K. A., & Wheelock, M. J. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20419 · Cited by 85
Aqp1 Enhances Migration of Bone Marrow Mesenchymal Stem Cells Through Regulation of FAK and β-Catenin
Meng, F., Rui, Y., Xu, L., Wan, C., Jiang, X., & Li, G. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0185 · Cited by 81
Role of osteopontin in cellular signaling and metastatic phenotype
El‐Tanani, M. (2008) · Frontiers in bioscience · doi:10.2741/3004 · Cited by 81
Proinflammatory CD4+CD45RBhi Lymphocytes Promote Mammary and Intestinal Carcinogenesis in Apc Min/+ Mice
Rao, V. P., Poutahidis, T., Ge, Z., Nambiar, P. R., Horwitz, B. H., Fox, J. G., & Erdman, S. E. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3445 · Cited by 81
Cancer stem cells and hepatocellular carcinoma
Yao, Z., & Mishra, L. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.18.9843 · Cited by 81
Atherosclerotic Calcification: Wnt Is the Hint
Albanese, I., Khan, K., Barratt, B., Kindi, H. N. A., & Schwertani, A. G. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.007356 · Cited by 88
Cell Polarity in Motion: Redefining Mammary Tissue Organization Through EMT and Cell Polarity Transitions
Gödde, N., Galea, R. C., Elsum, I. A., & Humbert, P. O. (2010) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-010-9180-2 · Cited by 85
Developmental functions of the P120-catenin sub-family
McCrea, P. D., & Park, J. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.06.009 · Cited by 84
Clinical Significance and Prognosis Value of Wnt Signaling Pathway in Cervical Cancer
Bahrami, A., Hasanzadeh, M., Shahidsales, S., Yousefi, Z., Kadkhodayan, S., Farazestanian, M., Mashhad, M. J., Gharib, M., Hassanian, S. M., & Avan, A. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25992 · Cited by 78
A novel β-catenin signaling pathway activated by IL-1β leads to the onset of epithelial–mesenchymal transition in breast cancer cells
Pérez-Yépez, E. A., Ayala‐Sumuano, J., Lezama, R. A., & Meza, I. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.08.015 · Cited by 77
MUC1-C Oncoprotein Induces TCF7L2 Transcription Factor Activation and Promotes Cyclin D1 Expression in Human Breast Cancer Cells
Rajabi, H. N., Ahmad, R., Jin, C., Kosugi, M., Alam, M., Joshi, M. D., & Kufe, D. W. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.323311 · Cited by 81
Stem/Progenitor Cells in Mouse Mammary Gland Development and Breast Cancer
Li, Y., & Rosen, J. M. (2005) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-005-2537-2 · Cited by 73
SOX9 Regulates Low Density Lipoprotein Receptor-related Protein 6 (LRP6) and T-cell Factor 4 (TCF4) Expression and Wnt/β-catenin Activation in Breast Cancer
Wang, H., He, L., Ma, F., Regan, M. M., Balk, S. P., Richardson, A. L., & Yuan, X. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.419184 · Cited by 73
Sclerostin is expressed in osteoclasts from aged mice and reduces osteoclast‐mediated stimulation of mineralization
Ota, K., Quint, P. S., Ruan, M. M., Pederson, L. G., Westendorf, J. J., Khosla, S., & Oursler, M. J. (2013) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24537 · Cited by 70
The Wnt Signaling Antagonist Kremen1 is Required for Development of Thymic Architecture
Osada, M., Ito, E., Fermin, H. A., Vazquez-Cintron, E. J., Venkatesh, T., Friedel, R. H., & Pezzano, M. T. (2006) · Journal of Immunology Research · doi:10.1080/17402520600935097 · Cited by 70
Nmi (N‐Myc interactor) inhibits Wnt/β‐catenin signaling and retards tumor growth
Fillmore, R. A., Mitra, A., Xi, Y., Ju, J., Scammell, J. G., Shevde, L. A., & Samant, R. S. (2009) · International Journal of Cancer · doi:10.1002/ijc.24276 · Cited by 69
BMP-6 promotes E-cadherin expression through repressing δEF1 in breast cancer cells
Yang, S., Du, J., Wang, Z., Yuan, W., Qiao, Y., Zhang, M., Zhang, J., Gao, S., Yin, J., Sun, B., et al. (2007) · BMC Cancer · doi:10.1186/1471-2407-7-211 · Cited by 68
Pygopus and the Wnt signaling pathway: A diverse set of connections
Jessen, S., Gu, B., & Dai, X. (2008) · BioEssays · doi:10.1002/bies.20757 · Cited by 67
Expression of periostin in the serum of NSCLC and its function on proliferation and migration of human lung adenocarcinoma cell line (A549) in vitro
Hong, L., Sun, H., Lv, X., Yang, D., Zhang, J., & Shi, Y. P. (2009) · Molecular Biology Reports · doi:10.1007/s11033-009-9721-1 · Cited by 68
MMTV-Wnt1 and -ΔN89β-Catenin Induce Canonical Signaling in Distinct Progenitors and Differentially Activate Hedgehog Signaling within Mammary Tumors
Teissedre, B., Pinderhughes, A., Incassati, A., Hatsell, S. J., Hiremath, M., & Cowin, P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004537 · Cited by 68
Self-citation
Characterization and Comparison of Intercellular Adherent Junctions Expressed by Human Corneal Endothelial Cells In Vivo and In Vitro
Zhu, Y., Hayashida, Y., Kheirkhah, A., He, H., Chen, S.-Y., & Tseng, S. C. G. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-1693 · Cited by 64
Wnt modulation in bone healing
Schupbach, D., Comeau-Gauthier, M., Harvey, E., & Merle, G. (2020) · Bone · doi:10.1016/j.bone.2020.115491 · Cited by 60
The Molecular Basis of Wnt/β-Catenin Signaling Pathways in Neurodegenerative Diseases
Anand, A. A., Khan, M., Monica, V., & Kar, D. (2023) · International Journal of Cell Biology · doi:10.1155/2023/9296092 · Cited by 64
β-Catenin Is Not Necessary for Maintenance or Repair of the Bronchiolar Epithelium
Zemke, A. C., Teisanu, R. M., Giangreco, A., Drake, J. A., Brockway, B., Reynolds, S. D., & Stripp, B. R. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0407oc · Cited by 65
DNAJB6 Induces Degradation of β-Catenin and Causes Partial Reversal of Mesenchymal Phenotype
Mitra, A., Menezes, M. E., Shevde, L. A., & Samant, R. S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.094847 · Cited by 61
Feedback Regulation between Zipcode Binding Protein 1 and β-Catenin mRNAs in Breast Cancer Cells
Gu, W., Wells, A. L., Pan, F., & Singer, R. H. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00266-08 · Cited by 60
Apigenin inhibits the proliferation and invasion of osteosarcoma cells by suppressing the Wnt/β-catenin signaling pathway
Liu, X., Li, L., LV, L., Chen, D., Shen, L., & Xie, Z. (2015) · Oncology Reports · doi:10.3892/or.2015.4022 · Cited by 59
Knockdown of the long non-coding RNA HOTTIP inhibits colorectal cancer cell proliferation and migration and induces apoptosis by targeting SGK1
Liu, T., Tao, Y., Hu, H., & He, K. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.12.064 · Cited by 53
Estrogen receptor positivity in mammary tumors of Wnt-1 transgenic mice is influenced by collaborating oncogenic mutations
Zhang, X., Podsypanina, K., Huang, S., Mohsin, S. K., Chamness, G. C., Hatsell, S. J., Cowin, P., Schiff, R., & Li, Y. (2005) · Oncogene · doi:10.1038/sj.onc.1208597 · Cited by 54
Self-citation
The expression of β-catenin in different subtypes of breast cancer and its clinical significance
Li, S., Li, S., Sun, Y. H., & Li, L. (2014) · Tumor Biology · doi:10.1007/s13277-014-1975-0 · Cited by 53
Role of neural-cadherin in early osteoblastic differentiation of human bone marrow stromal cells cocultured with human umbilical vein endothelial cells
Li, H., Daculsi, R., Grellier, M., Bareille, R., Bourget, C., & Amédée, J. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00562.2009 · Cited by 53
A Tale of Two Signals: AR and WNT in Development and Tumorigenesis of Prostate and Mammary Gland
Pakula, H., Xiang, D., & Li, Z. (2017) · Cancers · doi:10.3390/cancers9020014 · Cited by 55
Regulation of p110δ PI 3-Kinase Gene Expression
Kok, K. B., Nock, G. E., Verrall, E., Mitchell, M., Hommes, D. W., Peppelenbosch, M. P., & Vanhaesebroeck, B. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005145 · Cited by 49
Ror2 regulates branching, differentiation, and actin-cytoskeletal dynamics within the mammary epithelium
Roarty, K. P., Shore, A. N., Creighton, C. J., & Rosen, J. M. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201408058 · Cited by 56
Lithium inhibits proliferation of human esophageal cancer cell line Eca-109 by inducing a G2/M cell cycle arrest
Wang, J., Wang, C.-L., Wen, J., Wang, Y., Hu, Y., & Ren, H. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.3982 · Cited by 48
Meta-analysis of breast cancer microarray studies in conjunction with conserved cis-elements suggest patterns for coordinate regulation
Smith, D. D., Sætrom, P., Snøve, O., Lundberg, C. G., Rivas, G. E., Glackin, C. A., & Larson, G. P. (2008) · BMC Bioinformatics · doi:10.1186/1471-2105-9-63 · Cited by 47
Dissecting the roles of β-catenin and cyclin D1 during mammary development and neoplasia
Rowlands, T. M., Pechenkina, I. V., Hatsell, S. J., Pestell, R. G., & Cowin, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1534601100 · Cited by 48
Self-citation
Context dependent reversion of tumor phenotype by connexin-43 expression in MDA-MB231 cells and MCF-7 cells: Role of β-catenin/connexin43 association
Talhouk, R., Fares, M.-B., Rahme, G. J., Hariri, H. H., Rayes, T. E., Dbouk, H. A., Bazzoun, D., Labban, D. A., & El-Sabban, M. E. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.10.002 · Cited by 46
Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1transgenic mice
Huang, S., Li, Y., Chen, Y., Podsypanina, K., Chamorro, M. N., Olshen, A. B., Desai, K. V., Tann, A. W., Petersen, D. W., Green, J. E., et al. (2005) · Genome biology · doi:10.1186/gb-2005-6-10-r84 · Cited by 46
LncRNA expression signatures of twist-induced epithelial-to-mesenchymal transition in MCF10A cells
Hu, P., Yang, J., Hou, Y., Zhang, H., Zeng, Z., Zhao, L., Yu, T., Tang, X., Tu, G., Cui, X., et al. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.10.001 · Cited by 44
The Wnt inhibitor dickkopf-1: a link between breast cancer and bone metastases
Kasoha, M., Juhasz-Böss, I., Herr, D., Ney, J. T., & Erich-Franz, S. (2015) · Clinical & Experimental Metastasis · doi:10.1007/s10585-015-9750-1 · Cited by 46
Androgen Receptor Expression and Bicalutamide Antagonize Androgen Receptor Inhibit β-Catenin Transcription Complex in Estrogen Receptor-Negative Breast Cancer
Huang, R., Han, J., Liang, X., Sun, S., Jiang, Y., Xia, B., Niu, M., Li, D., Zhang, J., Wang, S., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000484300 · Cited by 44
Different Roles of Estrogen Receptors α and β in the Regulation of E-Cadherin Protein Levels in a Mouse Mammary Epithelial Cell Line
Helguero, L. A., Lindberg, K., Gardmo, C., Schwend, T., Gustafsson, J.-Α., & Haldosén, L.-A. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0788 · Cited by 46
Clinical implications of β-catenin protein expression in breast cancer.
Wang, Z., Zhang, H., Hou, J., Niu, J., Ma, Z.-H., Zhao, H., & Liu, C. (2015) · PubMed Central · Cited by 41
In Vivo Anti-Tumor Effects of Citral on 4T1 Breast Cancer Cells via Induction of Apoptosis and Downregulation of Aldehyde Dehydrogenase Activity
Nigjeh, S. E., Yeap, S. K., Nordin, N., Rahman, H. S., & Rosli, R. (2019) · Molecules · doi:10.3390/molecules24183241 · Cited by 41
Tumor-suppressive Effects of Psoriasin (S100A7) Are Mediated through the β-Catenin/T Cell Factor 4 Protein Pathway in Estrogen Receptor-positive Breast Cancer Cells
Deol, Y. S., Nasser, M. W., Yu, L., Zou, X., & Ganju, R. K. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.225466 · Cited by 39
Tropomodulin 1 Expression Driven by NF-κB Enhances Breast Cancer Growth
Ito-Kureha, T., Koshikawa, N., Yamamoto, M., Semba, K., Yamaguchi, N., Yamamoto, T. S., Seiki, M., & Inoue, J. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3455 · Cited by 38
miR-141 as potential suppressor of β-catenin in breast cancer
Abedi, N., Mohammadi‐Yeganeh, S., Koochaki, A., Karami, F., & Paryan, M. (2015) · Tumor Biology · doi:10.1007/s13277-015-3738-y · Cited by 38
Overexpression of the Tumor Suppressor Gene Phosphatase and Tensin Homologue Partially Inhibits Wnt-1–Induced Mammary Tumorigenesis
Zhao, H., Cui, Y., Dupont, J., Sun, H., Hennighausen, L. G., & Yakar, S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0181 · Cited by 38
A slug, a fox, a pair of sox: Transcriptional responses to neural crest inducing signals
Heeg‐Truesdell, E., & LaBonne, C. (2004) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20011 · Cited by 38
LZTFL1 suppresses gastric cancer cell migration and invasion through regulating nuclear translocation of β-catenin
Wang, L., Guo, J., Wang, Q., Zhou, J., Xu, C., Teng, R., Chen, Y., Wei, Q., & Liu, Z. (2014) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-014-1753-9 · Cited by 37
Cellular transformation of human mammary epithelial cells by SATB2
Yu, W., Ma, Y., Ochoa, A. C., Shankar, S., & Srivastava, R. K. (2017) · Stem Cell Research · doi:10.1016/j.scr.2017.01.011 · Cited by 37
Loss of sfrp1 promotes ductal branching in the murine mammary gland
Gauger, K. J., Shimono, A., Crisi, G. M., & Schneider, S. S. (2012) · BMC Developmental Biology · doi:10.1186/1471-213x-12-25 · Cited by 37

Authors: Hatsell, S., Rowlands, T., Hiremath, M., & Cowin, P.
Affiliations: New York University (US)
Corresponding author: Cowin, Pamela
ORCID: Hatsell, Sarah
Cowin, Pamela
Venue: Journal of Mammary Gland Biology and Neoplasia
Publisher: Springer Science and Business Media LLC
Published: 2003-04
Volume: 8
Issue: 2
Pages: 145-158
ISSN: 1083-3021 (ISSN-L)
1573-7039
DOI: 10.1023/a:1025944723047
OpenAlex: W1520332974
Cited by: 209
References: 93
Citations by year: 2025: 2 · 2024: 9 · 2023: 7 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 8 · 2018: 5 · 2017: 11 · 2016: 3 · 2015: 14 · 2014: 10 · 2013: 7 · 2012: 10
FWCI: 1.09
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Journal of Mammary Gland Biology and Neoplasia (publishedVersion)
PubMed (publishedVersion)
Funders: Health Research Board
National Institute for Health and Care Research
National Institutes of Health
National Institute of General Medical Sciences (GM 47429, R01GM047429)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords: β-catenin, TCF/LEF transcription factors, mammary gland development, breast cancer, Wnt/β-catenin signaling, alveolarization, cyclin D1, c-Myc, cell fate determination, mammary gland hyperplasia, LEF1, alveolar expansion
MeSH terms: Animals, Breast Neoplasms, Cell Adhesion, Cell Division, Cell Survival, Cytoskeletal Proteins, DNA-Binding Proteins, Female, Humans, Mammary Glands, Animal, Models, Biological, Phenotype, Transcription Factors, Signal Transduction, Trans-Activators, Mammary Neoplasms, Animal, Cadherins, Up-Regulation, Proto-Oncogene Proteins c-myc, Mucin-1, Cyclin D1, Mammary Glands, Human, beta Catenin, Mice, Lymphoid Enhancer-Binding Factor 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

β-Catenin and Tcfs in Mammary Development and Cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks