The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Oxidative mechanism of arsenic toxicity and carcinogenesis
Abstract
Arsenic is a known toxin and carcinogen that is present in industrial settings and in the environment. The mechanisms of disease initiation and progression are not fully understood. In the last a few years, there has been increasing evidence of the correlation between the generation of reactive oxygen species (ROS), DNA damage, tumor promotion, and arsenic exposure. This article summarizes the current literature on the arsenic mediated generation of ROS and reactive nitrogen species (RNS) in various biological systems. This article also discusses the role of ROS and RNS in arsenic-induced DNA damage and activation of oxidative sensitive gene expression.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Arsenic is a potent carcinogen, leading to skin, bladder, liver, and lung cancers [60, 61].”
From Arsenic Contamination of Groundwater: A Review of Sources, Prevalence, Health Risks, and Strategies for Mitigation (2014) · cites this paper as [60]
Citations
Cites
Function and Activation of NF-kappaB in the Immune System
Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745
Arsenic speciation in the environment
Cullen, W. R., & Reimer, K. J. (1989) · Chemical Reviews · doi:10.1021/cr00094a002 · Cited by 2,587
Physiological functions of thioredoxin and thioredoxin reductase
Arnér, E. S. J., & Holmgren, A. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01701.x · Cited by 2,535
WISEMAN, H., & HALLIWELL, B. (1996) · Biochemical Journal · doi:10.1042/bj3130017 · Cited by 2,345
Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro
Imlay, J. A., Chin, S. M., & Linn, S. (1988) · Science · doi:10.1126/science.2834821 · Cited by 1,555 · cited 1×
“Reactive oxygen and nitrogen species such as superoxide anion (O 2 ), hydrogen peroxide (H 2 O 2 ), hydroxyl radical (OH), and nitric oxide (NO) are known to be important in mutagenesis and carcinogenesis [29, 30].”
BackgroundPrevalence of Skin Cancer in an Endemic Area of Chronic Arsenicism in Taiwan 2
Tseng, W.-P., Chu, H. M., How, S. W., Fong, J. M., Lin, C. S., & Yeh, S. (1968) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/40.3.453 · Cited by 787
Smith, A. H., Goycolea, M., Haque, R., & Biggs, M. L. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009507 · Cited by 756
Zhao, C. Q., Young, M. R., Diwan, B. A., Coogan, T. P., & Waalkes, M. P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10907 · Cited by 559
Jing, Y., Dai, J., Chalmers-Redman, R. M. E., Tatton, W. G., & Waxman, S. (1999) · Blood · doi:10.1182/blood.v94.6.2102 · Cited by 542
Induction of oxyradicals by arsenic: Implication for mechanism of genotoxicity
Liu, S. X., Athar, M., Lippai, I., Waldren, C. A., & Hei, T. K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1643 · Cited by 539
Flagged first, then by citations
Research works printed but not linked: 2
- Yamauchi H, Yamamura Y: Urinary inorganic arsenic and methylarsenic excretion following arsenate-rich seaweed ingestion. Sangyo Igaku — Jpn J Industrial Health 21: 47–54, 1979 · DOI
- Noguchi N, Niki E: Chemistry of active oxygen species and antioxidant, in Antioxidant status, diet, nutrition, and health. In: A.M. Papas (ed). CRC Press: New York, 1999, pp 3–20
Cited by
Sorted by citations
Valavanidis, A., Vlachogianni, T., Fiotakis, K., & Loridas, S. (2013) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph10093886 · Cited by 910
Kregel, K. C., & Zhang, H. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00327.2006 · Cited by 883
The role of cellular reactive oxygen species in cancer chemotherapy
Yang, H., Villani, R. M., Wang, H., Simpson, M. J., Roberts, M. S., Tang, M., & Liang, X. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0909-x · Cited by 794
Shankar, S., Shanker, U., & Shikha (2014) · The Scientific World Journal · doi:10.1155/2014/304524 · Cited by 616
“It results in the formation of excess ROS thereby damaging organisms [62, 63].”
BackgroundRetinoic acid and arsenic trioxide cooperate for apoptosis through phosphorylated RXR alpha
Tarrade, A., Bastien, J., Bruck, N., Bauer, A., Gianni, M., & Rochette-Egly, C. (2005) · Oncogene · doi:10.1038/sj.onc.1208402 · Cited by 23
Metadata
- Authors
- Shi, H., Shi, X., & Liu, K. J.
- Affiliations
- University of New Mexico (US)
- National Institute for Occupational Safety and Health (US)
- Corresponding author
- Liu, Ke Jian
- Venue
- Molecular and Cellular Biochemistry
- Published
- 2004-01
- Volume
- 255
- Issue
- 1-2
- Pages
- 67-78
- ISSN
- 0300-8177 (ISSN-L)
- 1573-4919
- OpenAlex
- W1973290552
- Semantic Scholar
- 0450d50a6adca9c8ed6344761a9c548ef3560975
- Cited by
- 684
- References
- 122
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 23 · 2023: 26 · 2022: 36 · 2021: 40 · 2020: 36 · 2019: 29 · 2018: 35 · 2017: 34 · 2016: 52 · 2015: 46 · 2014: 45 · 2013: 43 · 2012: 45
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Molecular and Cellular Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p20es009871-04)
- National Institute of Environmental Health Sciences (P30ES012072, P20ES09871)
- National Center for Research Resources (P20-RR15636, P20RR015636)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Arsenic contamination and mitigation
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- arsenic toxicity, arsenic carcinogenesis, reactive oxygen species, reactive nitrogen species, DNA damage, tumor promotion, oxidative stress, gene expression regulation, oxidative stress genes
- MeSH terms
- Animals, Antioxidants, Arsenic, Cattle, Cell Transformation, Neoplastic, DNA Damage, Free Radicals, Cricetinae, Humans, Neoplasms, Lipid Peroxidation, Gene Expression Regulation, Neoplastic, Tumor Suppressor Protein p53, Free Radical Scavengers, Reactive Oxygen Species, Oxidative Stress, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
