Cited by 684Arsenic contamination and mitigationHeavy Metal Exposure and ToxicityRedox biology and oxidative stress

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Oxidative mechanism of arsenic toxicity and carcinogenesis

Shi, Honglian, Shi, Xianglin, Liu, Ke Jian·2004·Molecular and Cellular Biochemistry

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Abstract

Arsenic is a known toxin and carcinogen that is present in industrial settings and in the environment. The mechanisms of disease initiation and progression are not fully understood. In the last a few years, there has been increasing evidence of the correlation between the generation of reactive oxygen species (ROS), DNA damage, tumor promotion, and arsenic exposure. This article summarizes the current literature on the arsenic mediated generation of ROS and reactive nitrogen species (RNS) in various biological systems. This article also discusses the role of ROS and RNS in arsenic-induced DNA damage and activation of oxidative sensitive gene expression.

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Background
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Authors: Shi, H., Shi, X., & Liu, K. J.
Affiliations: University of New Mexico (US)
National Institute for Occupational Safety and Health (US)
Corresponding author: Liu, Ke Jian
ORCID: Shi, Honglian
Shi, Xianglin
Liu, Ke Jian
Venue: Molecular and Cellular Biochemistry
Publisher: Springer Science and Business Media LLC
Published: 2004-01
Volume: 255
Issue: 1-2
Pages: 67-78
ISSN: 0300-8177 (ISSN-L)
1573-4919
DOI: 10.1023/b:mcbi.0000007262.26044.e8
OpenAlex: W1973290552
Semantic Scholar: 0450d50a6adca9c8ed6344761a9c548ef3560975
Cited by: 684
References: 122
Citations by year: 2026: 5 · 2025: 10 · 2024: 23 · 2023: 26 · 2022: 36 · 2021: 40 · 2020: 36 · 2019: 29 · 2018: 35 · 2017: 34 · 2016: 52 · 2015: 46 · 2014: 45 · 2013: 43 · 2012: 45
FWCI: 1.45
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Molecular and Cellular Biochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p20es009871-04)
National Institute of Environmental Health Sciences (P30ES012072, P20ES09871)
National Center for Research Resources (P20-RR15636, P20RR015636)
Topics: Physical Sciences › Environmental Science › Environmental Chemistry › Arsenic contamination and mitigation
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: arsenic toxicity, arsenic carcinogenesis, reactive oxygen species, reactive nitrogen species, DNA damage, tumor promotion, oxidative stress, gene expression regulation, oxidative stress genes
MeSH terms: Animals, Antioxidants, Arsenic, Cattle, Cell Transformation, Neoplastic, DNA Damage, Free Radicals, Cricetinae, Humans, Neoplasms, Lipid Peroxidation, Gene Expression Regulation, Neoplastic, Tumor Suppressor Protein p53, Free Radical Scavengers, Reactive Oxygen Species, Oxidative Stress, Mice, Rats

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Oxidative mechanism of arsenic toxicity and carcinogenesis

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