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Cited by 35Antifungal resistance and susceptibilityFungal and yeast genetics researchBioactive Compounds and Antitumor Agents

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Enhancement of Amphotericin B Activity Against Candida albicans by Superoxide Radical

Okamoto, Yuichi, Aoki, Shigeji, Mataga, Izumi·2004·Mycopathologia
DOI 10.1023/b:myco.0000038430.20669.80
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Abstract

This study aimed to examine the involvement of oxidative damage in amphotericin B (AmB) activity against Candida albicans using the superoxide (O2-) generator paraquat (PQ). The effects of PQ on AmB activities against growth, viability, membrane permeability and respiration were examined in a wild-type parent strain (K) and a respiration-deficient mutant (KRD-19) since PQ-induced superoxide generation depends on respiration. In the parent strain, the minimal inhibitory concentration (MIC) of AmB, 0.25 microg/ml, tested with a liquid culture was lowered to 0.025 microg/ml by 1 mM PQ. Such a PQ-induced decrease in the MIC value of AmB was minimal in the mutant. Similar PQ-induced enhancement of AmB activity toward the parent strain was also observed with growth on an agar medium. In viability tests, when candidal cells were exposed to AmB (0.1 microg/ml) for I h, the lethality of AmB was enhanced by 1 mM PQ only in the parent strain. Exogenous superoxide dismutase and catalase failed to diminish the enhancing effect of PQ on the growth inhibitory activity of AmB in the parent strain, suggesting an interaction between superoxide and AmB in candidal cells. The enhancement of AmB activity by PQ, observed preferentially in the wild-type strain, can be explained by extensive superoxide generation depending on respiration. These results suggest that oxidative damage induced by superoxide is involved in AmB activity against C. albicans.

Overview

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Crossref · 10.1023/b:myco.0000038430.20669.80

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12 of 12 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 12 references

Research works printed but not linked: 2

  1. Aoki S, Ito-Kuwa S. Respiration of Candida albicansin relation to its morphogenesis. Plant Cell Physiol 1982; 23: 721–726.
  2. Odds FC. Candidaand Candidosis. 2nd ed. London: Bailliere Tindall, 1988.

Cited by

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Metadata

Authors
Okamoto, Y., Aoki, S., & Mataga, I.
Affiliations
Nippon Dental University (JP)
Venue
Mycopathologia
Publisher
Springer Science and Business Media LLC
Published
2004-08
Volume
158
Issue
1
Pages
9-15
ISSN
  • 0301-486X (ISSN-L)
  • 1573-0832
DOI
10.1023/b:myco.0000038430.20669.80
OpenAlex
W2063278261
Cited by
35
References
12
Citations by year
2024: 1 · 2023: 3 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2013: 5 · 2012: 5
FWCI
1.06
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Mycopathologia (publishedVersion)
  • PubMed (publishedVersion)
Funders
Chiba University
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
Keywords
amphotericin B, Candida albicans, superoxide, paraquat, oxidative stress, antifungal synergy, respiration-deficient mutants, membrane permeability, fungal viability, superoxide dismutase, catalase, minimum inhibitory concentration
MeSH terms
Amphotericin B, Animals, Antifungal Agents, Candida albicans, Cattle, Cell Survival, Drug Synergism, Microbial Sensitivity Tests, Paraquat, Polarography, Superoxides, Mutagenesis, Cell Respiration

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CoChat. (2026). Citation check: Enhancement of Amphotericin B Activity Against Candida albicans by Superoxide Radical. https://app.cochat.ai/papers/10.1023/b:myco.0000038430.20669.80
The paper
Okamoto, Y., Aoki, S., & Mataga, I. (2004). Enhancement of Amphotericin B Activity Against Candida albicans by Superoxide Radical. Mycopathologia. https://doi.org/10.1023/b%3Amyco.0000038430.20669.80

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.