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Cited by 141Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsAdvanced Polymer Synthesis and Characterization

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Block Copolymer Design for Camptothecin Incorporation into Polymeric Micelles for Passive Tumor Targeting

Opanasopit, Praneet, Yokoyama, Masayuki, Watanabe, Masato, Kawano, Kumi, Maitani, Yoshie, Okano, Teruo·2004·Pharmaceutical Research
DOI 10.1023/b:pham.0000048190.53439.eb
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Abstract

Purpose Polymeric micelles were designed for targeting of a water-insoluble anticancer agent, camptothecin (CPT). Chemical structures of inner core segment were optimized to achieve high incorporation efficiency and stable CPT-loaded micelles.Methods Poly(ethylene glycol)-poly(beta-benzyl L-aspartate) block copolymer (PEG-PBLA) was synthesized. The PBLA chain was modified by alkaline hydrolysis of its benzyl group followed by esterification with benzyl, n-butyl, and lauryl groups. Incorporation of CPT into micelles was carried out by an evaporation method. The stability of drug-loaded micelles was studied by gel-permeation chromatography (GPC), and their in vitro release behaviors were analyzed.Results CPT was incorporated into polymeric micelles constructed by various block copolymers. Among the esterified groups, block copolymers with high benzyl ester contents showed high CPT loading efficiency and stable CPT-loaded micelles. In chain lengths, 5-27 Bz-69 showed the highest incorporation efficiency. In contrast, 5-52 Bz-67, which had a longer hydrophobic chain, showed low incorporation efficiency. Release of CPT from the micelles was dependent on the benzyl contents and chain lengths. Sustained release was obtained when the benzyl content was high.Conclusions CPT was successfully incorporated into polymeric micelles with high efficiency and stability by optimizing chemical structures of the inner core segment.

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Research works printed but not linked: 1

  1. J. Fassberg and V. J. Stella. A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues. J. Pharm. Sci. 81:676–684 (1992). · DOI

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Metadata

Authors
Opanasopit, P., Yokoyama, M., Watanabe, M., Kawano, K., Maitani, Y., & Okano, T.
Affiliations
  • Tokyo Women's Medical University (JP)
  • Kanagawa Academy of Science and Technology (JP)
  • Hoshi University (JP)
Corresponding author
Okano, Teruo
ORCID
Venue
Pharmaceutical Research
Publisher
Springer Science and Business Media LLC
Published
2004-11
Volume
21
Issue
11
Pages
2001-2008
ISSN
  • 0724-8741 (ISSN-L)
  • 1573-904X
DOI
10.1023/b:pham.0000048190.53439.eb
OpenAlex
W2030626376
Cited by
141
References
34
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 9 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 9 · 2013: 9 · 2012: 6
FWCI
4.91
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Pharmaceutical Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
Keywords
camptothecin, polymeric micelles, poly(β-benzyl-L-aspartate), drug incorporation efficiency, micelle stability, sustained drug release, passive tumor targeting
MeSH terms
Antineoplastic Agents, Phytogenic, Aspartic Acid, Biopolymers, Buffers, Camptothecin, Chemistry, Physical, Chromatography, Gel, Chromatography, High Pressure Liquid, Lactones, Micelles, Phosphates, Polyethylene Glycols, Proteins, Pyrenes, Drug Delivery Systems, Chemical Phenomena

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