The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Montelukast reduces airway eosinophilic inflammation in asthma: a randomized, controlled trial
Open accessAbstract
Leukotrienes are pro-inflammatory mediators which may contribute to tissue, sputum, and blood eosinophilia seen in allergic and inflammatory diseases, including asthma. Montelukast is a cysteinyl leukotriene1 (CysLT1) receptor antagonist which improves asthma control; the aim of this study was to investigate its effect on induced sputum eosinophils. Montelukast 10 mg (n=19) or placebo (n=21) were administered orally once in the evening for 4 weeks to 40 chronic adult asthmatic patients, aged 19-64 yrs, in a double-blind, randomized, parallel group study. Patients were included if, at prestudy, they had >5% sputum eosinophils, symptomatic asthma with a forced expiratory volume in one second > or =65% of the predicted value and were being treated only with "as needed" inhaled beta2-agonists. In addition to sputum eosinophils, blood eosinophils and clinical endpoints were also assessed. Four weeks of montelukast treatment decreased sputum eosinophils from 7.5% to 3.9% (3.6% decrease, 95% confidence interval (CI) -16.6-0.4). In contrast, placebo treatment was associated with an increase in sputum eosinophils from 14.5% to 17.9% (3.4% increase, 95% CI -3.5-9.8). The least squares mean difference between groups (-11.3%, 95% CI -21.1-(-1.4)) was significant (p=0.026). Compared with placebo, montelukast significantly reduced blood eosinophils (p=0.009), asthma symptoms (p=0.001) and beta2-agonist use (p<0.001) while significantly increasing morning peak expiratory flow (p=0.001). Montelukast was generally well tolerated in this study, with a safety profile similar to the placebo. These results demonstrate that montelukast decreases airway eosinophilic inflammation in addition to improving clinical parameters. Its efficacy in the treatment of chronic asthma may be due, in part, to the effect on airway inflammation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A concordance correlation coefficient to evaluate reproducibility.
Lin, L. I.-K. (1989) · Biometrics · doi:10.2307/2532051 · Cited by 8,785
Eosinophilic Inflammation in Asthma
Bousquet, J., Chanez, P., Lacoste, J. Y., Barnéon, G., Ghavanian, N., Enander, I., Venge, P., Ahlstedt, S., Simony-Lafontaine, J., Godard, P., et al. (1990) · New England Journal of Medicine · doi:10.1056/nejm199010113231505 · Cited by 2,499
Pizzichini, E., Pizzichini, M. M., Efthimiadis, A., Evans, S., Morris, M. M., Squillace, D., Gleich, G. J., Dolovich, J., & Hargreave, F. E. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.154.2.8756799 · Cited by 966
Self-citationUse of induced sputum cell counts to investigate airway inflammation in asthma.
Pin, I., Gibson, P. G., Kolendowicz, R., Girgis-Gabardo, A., Denburg, J. A., Hargreave, F. E., & Dolovich, J. (1992) · Thorax · doi:10.1136/thx.47.1.25 · Cited by 913
Self-citationLeff, J. A., Busse, W. W., Pearlman, D., Bronsky, E. A., Kemp, J., Hendeles, L., Dockhorn, R., Kundu, S., Zhang, J., Seidenberg, B. C., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199807163390302 · Cited by 552
Self-citationStatistic Notes: Regression towards the mean
Bland, J. M., & Altman, D. G. (1994) · BMJ · doi:10.1136/bmj.308.6942.1499 · Cited by 547
Leukotriene E4 and granulocytic infiltration into asthmatic airways
Laitinen, L. A., Haahtela, T., Vilkka, V, Lee, T. H., & Spur, B. W. (1993) · The Lancet · doi:10.1016/0140-6736(93)91073-u · Cited by 526
Reiss, T. F. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.11.1213 · Cited by 484
Self-citationCellular and Biochemical Analysis of Induced Sputum from Asthmatic and from Healthy Subjects
Fahy, J. V., Liu, J., Wong, H., & Boushey, H. A. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/147.5.1126 · Cited by 422
Hankinson, J. L., & Gardner, R. M. (1988) · American Review of Respiratory Disease · doi:10.1164/ajrccm/137.2.493c · Cited by 369
Cited by
Allergic Rhinitis and Its Impact on Asthma
Bousquet, J., van Cauwenberge, P., & Khaltaev, N. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.118891 · Cited by 3,588
Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial
Green, R. H., Brightling, C. E., McKenna, S., Hargadon, B., Parker, D., Bradding, P., Wardlaw, A. J., & Pavord, I. D. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11679-5 · Cited by 1,755
Szefler, S. J., Wenzel, S., Brown, R., Erzurum, S. C., Fahy, J. V., Hamilton, R. G., Hunt, J. F., Kita, H., Liu, A. H., Panettieri, R. A., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.12.979 · Cited by 395
Meltzer, E. O. (2000) · Annals of Allergy, Asthma & Immunology · doi:10.1016/s1081-1206(10)62750-0 · Cited by 67
Suppression of the early and late cutaneous allergic responses using fexofenadine and montelukast
Simons, F. E. R., Johnston, L., Gu, X., & Simons, K. J. (2001) · Annals of Allergy, Asthma & Immunology · doi:10.1016/s1081-1206(10)62354-x · Cited by 48
Metadata
- Authors
- Pizzichini, E., Leff, J. A., Reiss, T. F., Hendeles, L., Boulet, L.-P., Wei, L. X., Efthimiadis, A. E., Zhang, J., & Hargreave, F. E.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 1999-07
- Volume
- 14
- Issue
- 1
- Pages
- 12
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2033984690
- Cited by
- 332
- References
- 25
- FWCI
- 16.78
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Montelukast reduces airway eosinophilic inflammation in asthma: a randomized, controlled trial. https://app.cochat.ai/papers/10.1034/j.1399-3003.1999.14a04.x
- The paper
- Pizzichini, E., Leff, J. A., Reiss, T. F., Hendeles, L., Boulet, L.-P., Wei, L. X., Efthimiadis, A. E., Zhang, J., & Hargreave, F. E. (1999). Montelukast reduces airway eosinophilic inflammation in asthma: a randomized, controlled trial. European Respiratory Journal. https://doi.org/10.1034/j.1399-3003.1999.14a04.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
