Development and validation of the Mini Asthma Quality of Life Questionnaire
Open accessAbstract
The 32-item Asthma Quality of Life Questionnaire (AQLQ) has shown good responsiveness, reliability and construct validity; properties that are essential for use in clinical trials, clinical practice and surveys. However, to meet the needs of large clinical trials and long-term monitoring, where efficiency may take precedent over precision of measurement, the 15-item self-administered MiniAQLQ has been developed. The MiniAQLQ was tested in a 9-week observational study of 40 adults with symptomatic asthma. Patients completed the MiniAQLQ, the AQLQ, the Short Form (SF)-36, the Asthma Control Questionnaire and spirometry at baseline, 1, 5 and 9 weeks. In patients whose asthma was stable between clinic visits, reliability was very acceptable for the MiniAQLQ (intraclass correlation coefficient (ICC)=0.83), but not quite as good as for the AQLQ (ICC=0.95). Similarly, responsiveness in the MiniAQLQ (p=0.0007) was good but not quite so good as for the AQLQ (p<0.0001). Construct validity (correlation with other indices of health status) was strong for both the MiniAQLQ and the AQLQ. Criterion validity showed that there was no bias between the instruments (p=0.61) and the correlation between them was high (r=0.90). The Mini Asthma Quality of Life Questionnaire has good measurement properties but they are not quite as strong as those of the original Asthma Quality of Life Questionnaire. The choice of questionnaire should depend on the task at hand.
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This has been widely acknowledged by previous research, to the extent that it has been included as one of the components of asthma-related QoL measures, such as the AQLQ.
“This has been widely acknowledged by previous research, to the extent that it has been included as one of the components of asthma-related QoL measures, such as the AQLQ.69”
From A systematic review of psychological, physical health factors, and quality of life in adult asthma (2019) · cites this paper as [69]
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- Authors
- Juniper, E. F., Guyatt, G. H., Cox, F. M., Ferrie, P. J., & King, D. R.
- Affiliations
- McMaster University Medical Centre (CA)
- ORCID
- Guyatt, G.H.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 1999-07
- Volume
- 14
- Issue
- 1
- Pages
- 32
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2122433348
- Cited by
- 786
- References
- 17
- Citations by year
- 2026: 21 · 2025: 33 · 2024: 34 · 2023: 47 · 2022: 32 · 2021: 37 · 2020: 34 · 2019: 32 · 2018: 31 · 2017: 28 · 2016: 45 · 2015: 38 · 2014: 37 · 2013: 34 · 2012: 31
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Keywords
- Mini Asthma Quality of Life Questionnaire, Asthma Quality of Life Questionnaire, asthma, health-related quality of life, questionnaire development, measurement properties, reliability statistics, responsiveness, construct validity, criterion validity, short-form questionnaire
- MeSH terms
- Adolescent, Adult, Aged, Asthma, Cross-Sectional Studies, Evaluation Studies as Topic, Female, Follow-Up Studies, Humans, Male, Middle Aged, Office Visits, Quality of Life, Surveys and Questionnaires, Respiratory Function Tests, Sensitivity and Specificity, Reproducibility of Results
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