The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
A critical discussion of the role of neuroimaging in mild cognitive impairment*: Neuroimaging in MCI
Abstract
OBJECTIVE: In this paper, the current neuroimaging literature is reviewed with regard to characteristic findings in mild cognitive impairment (MCI). Particular attention is drawn to the possible value of neuroimaging modalities in the prediction and early diagnosis of Alzheimer's disease (AD). METHODS: First, the potential contribution of neuroimaging to an early, preclinical diagnosis of degenerative disorders is discussed at the background of our knowledge about the pathogenesis of AD. Second, relevant neuroimaging studies focusing on MCI are explored and summarized. Neuroimaging studies were found through Medline search and by systematically checking through the bibliographies of relevant articles. RESULTS: Structural volumetric magnetic resonance imaging (MRI) and positron emission tomography (PET)/single photon emission tomography (SPECT) are currently the most commonly used neuroimaging modalities in studies focusing on MCI. There were considerable variations in demographical and clinical characteristics across studies. However, significant hippocampal and entorhinal cortex volume reductions were consistently found in subjects with MCI as compared with cognitively unimpaired controls. While hippocampal and entorhinal cortex atrophy in subjects with MCI are also well-established risk factors for the development of AD, these measures cannot be regarded as being of high predictive value in an individual case. Evidence for other typical neuroimaging changes in MCI is still scarce. In PET and SPECT studies, reduced blood flow and/or glucose metabolism in temporoparietal association areas, posterior cingulate and hippocampus were associated with a higher risk of progressive cognitive decline in MCI. In quantitative electroencephalogram (QEEG), low beta, high theta, low alpha and slowed mean frequency were associated with development of dementia. CONCLUSIONS: Existing studies suggest that neuroimaging measures have the potential to become valuable tools in the early diagnosis of AD. To establish their value in routine use, larger studies, preferably with long prospective follow-up are needed.
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Cites
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Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
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Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease
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“Neuron loss in AD predilection areas was reported to be as high as 87% in subregions of the hippocampus (16) and up to 60% in the entorhinal cortex (17), even in early disease stages.”
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Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment
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“In addition to constitutional reserve markers, such as genetic factors, age and brain volume (20), co-occurrant pathological conditions, primarily cerebrovascular lesions (21), may alter the individual reserve capacity.”
BackgroundMedial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease
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Cited by
CSF markers for incipient Alzheimer's disease
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Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment
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Cognitive reserve and the neurobiology of cognitive aging
Whalley, L. J., Deary, I. J., Appleton, C. L., & Starr, J. M. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2004.05.001 · Cited by 460
Variation in neural development as a result of exposure to institutionalization early in childhood
Sheridan, M. A., Fox, N. A., Zeanah, C. H., McLaughlin, K. A., & Nelson, C. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200041109 · Cited by 432
Metadata
- Authors
- Wolf, H., Jelic, V., Gertz, H.-J., Nordberg, A., Julin, P., & Wahlund, L.-O.
- Venue
- Acta Neurologica Scandinavica
- Publisher
- Wiley
- Published
- 2003-02
- Volume
- 107
- Pages
- 52-76
- ISSN
- 0001-6314 (ISSN-L)
- OpenAlex
- W2016158653
- Cited by
- 213
- References
- 22
- FWCI
- 13.24
- Type
- journal article
- Language
- en
- Open access
- closed
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