Pharmacotherapy of social phobia

Davidson, J. R. T.

doi:10.1034/j.1600-0447.108.s417.7.x

Cited by 69Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesTreatment of Major DepressionSchizophrenia research and treatment

Pharmacotherapy of social phobia

Davidson, J. R. T.·2003·Acta Psychiatrica Scandinavica

DOI 10.1034/j.1600-0447.108.s417.7.x

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Abstract

OBJECTIVE: To review placebo-controlled medication trials in social phobia (SP). METHOD: Published and/or presented placebo-controlled trials of medication were reviewed and summarized. RESULTS: Phenelzine is effective in 60-70% of patients with SP and always superior to placebo. Although reversible inhibitors of monoamine oxidase type A (RIMAs) are safer, their benefits are unpredictable. SSRIs, fluvoxamine, paroxetine and sertraline are superior to placebo in generalized SP. Gabergic drugs are useful, e.g. clonazepam, gabapentin and pregabalin. Promising effects have been found with venlafaxine, a serotonin-norepinephrine reuptake inhibitor, and the results of larger studies should be forthcoming in the next 2 years. Drugs such as buspirone, tricyclics and beta-blockers are either ineffective or have limited use. SP is a chronic disorder, and early termination of successful pharmacotherapy is associated with a greater likelihood of relapse. Studies with paroxetine, clonazepam, sertraline and brofaromine show that continued treatment is associated with better maintenance of response. Special populations that require further study include children, those with comorbid Axis I disorders and the population with discrete (non-generalized) SP. CONCLUSION: MAOI and SSRI are most uniformly effective in treating SP. Clonazepam and gabapentin may also be useful. Other drugs are of more limited value. Long-term treatment is recommended to reduce rates of relapse.

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Although effective behavioral and pharmacological interventions exist, many people struggling with SAD experience ongoing symptoms following treatment or do not present for treatment, indicating room for innovation in SAD treatment strategies.
“Although effective behavioral and pharmacological interventions exist, many people struggling with SAD experience ongoing symptoms following treatment (16, 167) or do not present for treatment (5) indicating room for innovation in SAD treatment strategies.”
From MDMA-Assisted Therapy as a Means to Alter Affective, Cognitive, Behavioral, and Neurological Systems Underlying Social Dysfunction in Social Anxiety Disorder (2021) · cites this paper as [167]

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Authors: Davidson, J. R. T.
Affiliations: Duke Medical Center (US)
Corresponding author: Davidson, J. R. T.
ORCID: Davidson, J. R. T.
Venue: Acta Psychiatrica Scandinavica
Publisher: Wiley
Published: 2003-08-29
Volume: 108
Issue: s417
Pages: 65-71
ISSN: 0001-690X (ISSN-L)
1600-0447
DOI: 10.1034/j.1600-0447.108.s417.7.x
OpenAlex: W2049821022
Cited by: 69
References: 46
Citations by year: 2024: 1 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 5 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 5
FWCI: 0.72
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Acta Psychiatrica Scandinavica (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: social anxiety disorder, pharmacotherapy, phenelzine, selective serotonin reuptake inhibitors, paroxetine, sertraline, fluvoxamine, gabapentin, clonazepam, pregabalin, venlafaxine, buspirone, tricyclic antidepressants, beta-blockers, relapse prevention, long-term maintenance therapy, generalized social phobia, children
MeSH terms: Adolescent, Adult, Aged, Child, Female, Humans, Male, Middle Aged, Monoamine Oxidase Inhibitors, Phobic Disorders, Placebos, Randomized Controlled Trials as Topic, Selective Serotonin Reuptake Inhibitors

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