Compliance with antipsychotic treatment
Abstract
Objective: Despite the demonstrated efficacy of antipsychotics the relapse rate among patients with schizophrenia remains high. One major reason for this is non‐compliance. In this article we review different factors influencing compliance and discuss possibilities to enhance compliance among schizophrenic patients. Method: This review is based on a systematic literature search in Medline. Results: We summarize the four main factors (patient‐, environment‐, physician‐ and treatment‐related) that influence compliance and discuss possible measures to enhance compliance. Next to many other variables discussed in more detail, it is crucial to ensure a positive doctor–patient relationship and to provide sufficient information about the benefit/risk ratio of the medication as well as about the illness itself to build up and sustain compliance. Significant others should be included into the therapeutic alliance whenever possible. Conclusion: Despite many published reports on compliance, it remains to be a problem of eminent clinical relevance. Clinicians must not underestimate it in order to optimize the treatment of patients with schizophrenia.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Semaglutide's long-acting formulation offers advantages in severe mental illness, where medication non-adherence is a larger issue compared to other medical conditions.
“Semaglutide’s availability as a long-acting formulation offers advantages in SMI, where medication non-adherence is a larger issue compared to other medical conditions.45,46”
From Semaglutide for the treatment of antipsychotic-associated weight gain in patients not responding to metformin – a case series (2023) · cites this paper as [45]
Cites
Sociobehavioral Determinants of Compliance with Health and Medical Care Recommendations
Becker, M. H., & Maiman, L. A. (1975) · Medical Care · doi:10.1097/00005650-197501000-00002 · Cited by 1,584 · see citing works
Lehman, A. F., Steinwachs, D. M., & The Survey Co-Investigators of the PORT Project (1998) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033303 · Cited by 594 · see citing works
Randomised controlled trial of compliance therapy
Kemp, R., Kirov, G., Everitt, B. J., Hayward, P., & David, A. S. (1998) · The British Journal of Psychiatry · doi:10.1192/bjp.172.5.413 · Cited by 525 · see citing works
Alcohol Use and Abuse in Schizophrenia
Drake, R. E., Osher, F. C., & Wallach, M. A. (1989) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198907000-00004 · Cited by 476 · see citing works
Medication noncompliance and substance abuse among patients with schizophrenia
Owen, R. R., Fischer, E. P., Booth, B. M., & Cuffel, B. J. (1996) · Psychiatric Services · doi:10.1176/ps.47.8.853 · Cited by 330 · see citing works
Drug Refusal in Schizophrenia and the Wish to Be Crazy
Putten, T. V. (1976) · Archives of General Psychiatry · doi:10.1001/archpsyc.1976.01770120047004 · Cited by 259 · see citing works
Blackwell, B. (1976) · The British Journal of Psychiatry · doi:10.1192/bjp.129.6.513 · Cited by 253 · see citing works
Non-compliance—or how many aunts has Matilda?
Wright, E. C. (1993) · The Lancet · doi:10.1016/0140-6736(93)91951-h · Cited by 221 · see citing works
Medication Errors Made by Elderly, Chronically Ill Patients
Schwartz, D., Wang, M., Zeitz, L., & Goss, M. E. W. (1962) · American Journal of Public Health and the Nations Health · doi:10.2105/ajph.52.12.2018 · Cited by 214 · see citing works
Medication noncompliance in schizophrenia: codification and update.
Young, J. L., Zonana, H. V., & Shepler, L. (1986) · PubMed · Cited by 198 · see citing works
Shope, J. T. (1983) · Patient Education and Counseling · doi:10.1016/0738-3991(83)90077-0 · Cited by 164 · see citing works
Akathisia With Haloperidol and Thiothixene
Putten, T. V. (1984) · Archives of General Psychiatry · doi:10.1001/archpsyc.1983.01790220026004 · Cited by 161 · see citing works
Sullivan, G., Wells, K. B., Morgenstern, H., & LEAKE, B. D. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.12.1749 · Cited by 160 · see citing works
A comparison of patients who refuse and consent to neuroleptic treatment
Marder, S. R., Mebane, A. H., Chien, C., et al. (1983) · American Journal of Psychiatry · doi:10.1176/ajp.140.4.470 · Cited by 155 · see citing works
Compliance With Short-Term Antimicrobial Therapy: Some Techniques That Help
Lima, J. J., Nazarian, L. F., Charney, E., et al. (1976) · PEDIATRICS · doi:10.1542/peds.57.3.383 · Cited by 74 · see citing works
Family Characteristics, Substance Abuse, and Hospitalization Patterns of Patients With Schizophrenia
Kashner, T. M., Rader, L. E., Rodell, D. E., Beck, C. M., Rodell, L., & Muller, K. (1991) · Psychiatric Services · doi:10.1176/ps.42.2.195 · Cited by 72 · see citing works
The combat of non‐compliance during prophylactic lithium treatment
Schou, M. (1997) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1997.tb09646.x · Cited by 64 · see citing works
Age and other factors relevant to the rehospitalization of schizophrenic outpatients
Hoffmann, H. (1994) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1994.tb08093.x · Cited by 40 · see citing works
Assessment of complicance-related attitudes in psychiatry
Ludwig, W., Huber, D., Schmidt, S., et al. (1990) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/bf00782884 · Cited by 23 · see citing works
Antipsychotic Maintenance Treatment of Schizophrenia Patients: Is There a Consensus?
Meise, U., Kurz, M., & Fleischhacker, W. W. (1994) · Schizophrenia Bulletin · doi:10.1093/schbul/20.1.215 · Cited by 22 · see citing works
Self-citation[Which factors modify drug-compliance?].
Albus, M., Burkes, S., & Scherer, J. (1995) · PubMed · Cited by 9 · see citing works
Psychiatrische Erkrankungen bei Frauen
Brockington, I., & Lanczik, M. (2000) · Springer eBooks · doi:10.1007/978-3-642-59625-4_13 · Cited by 4 · see citing works
Attitudes towards illness, antipsychotic medication and compliance in outpatients with schizophrenia
Rettenbacher-Oehl, M., Hummer, M., Eder, U., et al. (1999) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(99)80343-5 · Cited by 1 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Huhn, M., Nikolakopoulou, A., Schneider-Thoma, J., Krause, M., Samara, M., Peter, N., Arndt, T., Bäckers, L., Rothe, P., Cipriani, A., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31135-3 · Cited by 1,753 · see citing works
Determinants of patient adherence: a review of systematic reviews
Kardas, P., Lewek, P., & Matyjaszczyk, M. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00091 · Cited by 809 · see citing works
Medication Adherence in Schizophrenia: Exploring Patients', Carers' and Professionals' Views
Kikkert, M. J., Schene, A. H., Koeter, M. W. J., Robson, D., Born, A., Helm, H., Nose, M., Goss, C., Thornicroft, G., & Gray, R. J. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbl011 · Cited by 164 · see citing works
Family intervention in schizophrenia
Berglund, N., Vahlne †, J. O., & Edman, Å. (2003) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-003-0615-6 · Cited by 150 · see citing works
Novick, D., Montgomery, W., Treuer, T., Aguado, J., Kraemer, S., & Haro, J. M. (2015) · BMC Psychiatry · doi:10.1186/s12888-015-0560-4 · Cited by 127 · see citing works
Prasad, F., De, R., Korann, V., Chintoh, A. F., Remington, G., Ebdrup, B. H., Siskind, D., Knop, F. K., Vilsbøll, T., Fink-Jensen, A., et al. (2023) · Therapeutic Advances in Psychopharmacology · doi:10.1177/20451253231165169 · Cited by 88 · see citing works
“45,46 Patients have also reported better quality of life and treatment satisfaction with once-weekly semaglutide in comparison to other drugs within the same drug class.”
BackgroundKimura, H., Kanahara, N., Komatsu, N., Ishige, M., Muneoka, K., Yoshimura, M., Yamanaka, H., Suzuki, T., Komatsu, H., Sasaki, T., et al. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.02.022 · Cited by 55 · see citing works
Chue, P., & Kovacs, C. S. (2003) · Bipolar Disorders · doi:10.1111/j.1399-2406.2003.00063.x · Cited by 32 · see citing works
- Authors
- Oehl, M., Hummer, M., & Fleischhacker, W. W.
- Affiliations
- Innsbruck Medical University (AT)
- Corresponding author
- Oehl, M.
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2000-12
- Volume
- 102
- Issue
- s407
- Pages
- 83-86
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W2012449264
- Cited by
- 151
- References
- 23
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 2 · 2021: 8 · 2020: 7 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 9 · 2015: 5 · 2014: 6 · 2013: 5 · 2012: 7
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- antipsychotic drugs, medication adherence, schizophrenia, relapse, physician-patient relationship, therapeutic relationship, family involvement, patient factors, physician characteristics, treatment-related factors
- MeSH terms
- Adult, Age Factors, Aged, Female, Humans, Male, Middle Aged, Patient Compliance, Physician-Patient Relations, Recurrence, Risk Factors, Schizophrenia, Antipsychotic Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
