Medication Adherence in Schizophrenia: Exploring Patients', Carers' and Professionals' Views
Open accessAbstract
One of the major clinical problems in the treatment of people with schizophrenia is suboptimal medication adherence. Most research focusing on determinants of nonadherence use quantitative research methods. These studies have some important limitations in exploring the decision-making process of patients concerning medication. In this study we explore factors influencing medication adherence behavior in people with schizophrenia using concept mapping. Concept mapping is a structured qualitative method and was performed in 4 European countries. Participants were 27 patients with schizophrenia, 29 carers, and 28 professionals of patients with schizophrenia. Five clinically relevant themes were identified that affect adherence: medication efficacy, external factors (such as patient support and therapeutic alliance), insight, side effects, and attitudes toward medication. Importance ratings of these factors differed significantly between professionals and carers and patients. Professionals, carers, and patients do not have a shared understanding of which factors are important in patients' medication adherence behavior. Adherence may be positively influenced if professionals focus on the positive aspects of medication, on enhancing insight, and on fostering a positive therapeutic relationship with patients and carers.
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“As previous reports have found differing views regarding factors affecting adherence among patients, caregivers and health professionals [14,23], we included participants representing these three perspectives.”
ResultDeng, M., Zhai, S., Ouyang, X., Liu, Z., & Ross, B. (2022) · BMC Psychiatry · doi:10.1186/s12888-021-03681-6 · Cited by 75 · see citing works
- Authors
- Kikkert, M. J., Schene, A. H., Koeter, M. W. J., Robson, D., Born, A., Helm, H., Nose, M., Goss, C., Thornicroft, G., & Gray, R. J.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- King's College London (GB)
- Leipzig University (DE)
- University of Verona (IT)
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-10-12
- Volume
- 32
- Issue
- 4
- Pages
- 786-794
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- PMC
- PMC2632275
- OpenAlex
- W2114947270
- Cited by
- 164
- References
- 49
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 8 · 2022: 6 · 2021: 7 · 2020: 11 · 2019: 5 · 2018: 1 · 2017: 2 · 2016: 10 · 2015: 13 · 2014: 7 · 2013: 10 · 2012: 14
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Schizophrenia Bulletin (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, other-oa)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- medication adherence, schizophrenia
- MeSH terms
- Adult, Attitude, Attitude of Health Personnel, Awareness, Concept Formation, Europe, Female, Humans, Male, Patient Education as Topic, Physician-Patient Relations, Psychotherapy, Quality of Life, Schizophrenia, Schizophrenic Psychology, Antipsychotic Agents, Treatment Refusal, Treatment Outcome, Caregivers
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