Anterior cingulotomy for refractory obsessive–compulsive disorder
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Objective This study was designed to prospectively investigate the efficacy and cognitive adverse effects of stereotactic bilateral anterior cingulotomy as a treatment for refractory obsessive-compulsive (OCD) patients for 12 months. Method Patients were eligible if they had severe OCD and rigorous treatments had been unsuccessful. Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), Clinical Global Impression (CGI) and neuropsychological tests were used to assess the efficacy and cognitive changes of cingulotomy before and 12 months after operation. Results The mean improvement rate of the Y-BOCS scores achieved from baseline was 36.0%. Out of 14 patients six met responder criteria; 35% or higher improvement rate on Y-BOCS and CGI improvement of very much or much better at 12-month follow-up. There was no significant cognitive dysfunction after cingulotomy. Conclusion Anterior cingulotomy shows few cognitive adverse effects, with about half of the OCD patients demonstrating significant symptomatic improvement.
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OCD sufferers after cingulotomy showed poorer WCST performance on several measures, consistent with a loss of executive control.
“Furthermore, OCD sufferers after cingulotomy showed poorer WCST performance on several measures (Kim et al., 2003; but see Corkin, 1980, Cohen et al., 1999b), consistent with a loss of executive control.”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Kim et al., 2003
A smaller group of cingulotomy patients (n = 14) treated for OCD showed impaired WCST performance.
“In contrast, a smaller group of cingulotomy patients (n = 14) treated for OCD showed impaired WCST performance (Kim et al., 2003).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Kim et al., 2003
No long-term changes have been found in performance of other memory tasks, including the Hopkins Verbal Learning Test, after cingulotomy.
“Similar studies have again found no long term changes in the performance of other memory tasks, including the Hopkins Verbal Learning Test (Kim et al., 2003; Jung et al., 2006).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Kim et al., 2003
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- Authors
- Kim, C. ‐., Chang, J. W., Koo, M. ‐., Kim, J. W., Suh, H. S., Park, I. H., & Lee, H. S.
- Affiliations
- Yonsei University (KR)
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2003-03-27
- Volume
- 107
- Issue
- 4
- Pages
- 283-290
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W2105521787
- Cited by
- 127
- References
- 7
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 5 · 2015: 8 · 2014: 9 · 2013: 8 · 2012: 4
- FWCI
- 10.18
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Keywords
- anterior cingulotomy, refractory obsessive-compulsive disorder, stereotactic neurosurgery, cognitive side effects, treatment efficacy, Yale-Brown Obsessive Compulsive Scale, neuropsychological outcomes
- MeSH terms
- Adult, Cognition Disorders, Female, Gyrus Cinguli, Humans, Male, Middle Aged, Obsessive-Compulsive Disorder, Psychosurgery, Severity of Illness Index, Treatment Outcome
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