Treatment of psychiatric illness by stereotactic cingulotomy

Ballantine, H.Thomas; Bouckoms, Anthony J.; Thomas, Elizabeth K.; Giriunas, Ida E.

doi:10.1016/0006-3223(87)90080-1

Cited by 329Neurological disorders and treatmentsObsessive-Compulsive Spectrum DisordersElectroconvulsive Therapy Studies

Treatment of psychiatric illness by stereotactic cingulotomy

Ballantine, H.Thomas, Bouckoms, Anthony J., Thomas, Elizabeth K., Giriunas, Ida E.·1987·Biological Psychiatry

DOI 10.1016/0006-3223(87)90080-1

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Abstract

The treatment of 198 psychiatrically disabled patients with stereotactic cingulotomy was evaluated prospectively for a mean follow-up of 8.6 years. Patients with major affective disorders and anxiety disorders fared the best, with a return to normal functioning in the majority. Patients with obsessive-compulsive disorders, schizophrenia, and personality disorders improved less predictably, with an uneven improvement in functioning that required active ongoing psychiatric treatment. Low mortality and morbidity, a reduction of violent behavior, a possible reduction of suicidal risk, and a lessening of the intractable suffering of chronic psychiatric illness all indicate that cingulotomy can be an effective, safe treatment for patients with affective disorders that are unresponsive to all other forms of therapy.

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A prospective analysis of 198 cases with bilateral cingulum bundle lesions pointed to lasting improvements in approximately half of those treated for obsessive compulsive disorders.
“A prospective analysis of 198 cases with bilateral cingulum bundle lesions (Ballantine et al., 1987) pointed to lasting improvements in approximately half of those treated for obsessive compulsive disorders (OCD)”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Ballantine et al., 1987
Cingulotomy outcomes are slightly better for anxiety disorders and affective disorders, including depression, than for OCD.
“with slightly better outcomes for anxiety disorders and affective disorders, including depression (Ballantine et al., 1987; Shields et al., 2008).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Ballantine et al., 1987

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Authors: Ballantine, H. T., Bouckoms, A. J., Thomas, E. K., & Giriunas, I. E.
Affiliations: Harvard University (US)
Massachusetts General Hospital (US)
Corresponding author: Ballantine, H.Thomas
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 1987-07
Volume: 22
Issue: 7
Pages: 807-819
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/0006-3223(87)90080-1
OpenAlex: W2064542914
Cited by: 328
References: 13
Citations by year: 2026: 4 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 8 · 2020: 7 · 2019: 4 · 2018: 21 · 2017: 5 · 2016: 6 · 2015: 10 · 2014: 12 · 2013: 18 · 2012: 11
FWCI: 3.68
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
Keywords: mental illness, mood disorders, anxiety disorders, obsessive-compulsive disorder, schizophrenia, personality disorders, treatment outcomes, long-term follow-up, violent behavior, suicide risk, refractory psychiatric disorders
MeSH terms: Adolescent, Adult, Aged, Anxiety Disorders, Mental Disorders, Child, Female, Follow-Up Studies, Gyrus Cinguli, Humans, Male, Middle Aged, Personality Disorders, Psychomotor Performance, Schizophrenia, Social Adjustment, Stereotaxic Techniques, Mood Disorders

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Treatment of psychiatric illness by stereotactic cingulotomy

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