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Red blood cell and platelet interactions with titanium implant surfaces
Abstract
The influence of the micro‐roughened surface, produced by dual acid‐etching (DAE) of machined commercially pure titanium, on initial blood cell/implant interactions was investigated by observing the blood components remaining at the implant surface following freeze‐fracture of clotted, and fixed, human blood. Glass surfaces were also used for immuno‐labelling studies to identify fibrin and platelets. The interface comprised predominantly fibrin and red blood cells (RBCs). The difference in distribution of RBCs was statistically significant (P<0.05) at 10 min of blood/implant contact, but diminished thereafter. Micro‐roughened DAE implant surfaces showed, qualitatively, more platelets than machined surfaces, while the textured glass surfaces demonstrated increased platelet aggregation. We believe that these early blood cell/implant interactions may play a key role in the osteoconduction stage of peri‐implant bone healing response to micro‐roughened implants.
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Cited by
Surface treatments of titanium dental implants for rapid osseointegration
Le Guéhennec, L., Soueidan, A., Layrolle, P., & Amouriq, Y. (2007) · Dental Materials · doi:10.1016/j.dental.2006.06.025 · Cited by 2,406
Tambasco de Oliveira, P., & Nanci, A. (2004) · Biomaterials · doi:10.1016/s0142-9612(03)00539-8 · Cited by 360
Platelet interactions with titanium: modulation of platelet activity by surface topography
Park, J. Y., Gemmell, C. H., & Davies, J. E. (2001) · Biomaterials · doi:10.1016/s0142-9612(01)00009-6 · Cited by 297
Self-citationRefai, A. K., Textor, M., Brunette, D. M., & Waterfield, J. D. (2004) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30075 · Cited by 296
Titanium–Tissue Interface Reaction and Its Control With Surface Treatment
Hanawa, T. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00170 · Cited by 284
Metadata
- Authors
- Park, J. Y., & Davies, J. E.
- Venue
- Clinical Oral Implants Research
- Publisher
- Wiley
- Published
- 2000-12
- Volume
- 11
- Issue
- 6
- Pages
- 530-539
- ISSN
- 0905-7161 (ISSN-L)
- 1600-0501
- OpenAlex
- W2016576220
- Cited by
- 299
- References
- 0
- FWCI
- 8.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Park, J. Y., & Davies, J. E. (2000). Red blood cell and platelet interactions with titanium implant surfaces. Clinical Oral Implants Research. https://doi.org/10.1034/j.1600-0501.2000.011006530.x
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