The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Rapid leukocyte integrin activation by chemokines
Abstract
Summary: Chemokines control selective targeting of circulating leukocytes to the microvasculature by triggering inside‐out signal transduction pathways leading to integrin‐dependent adhesion. Integrin activation by chemokines is very rapid, is downmodulated within minutes and appears to involve both enhanced heterodimer lateral mobility on the plasma membrane, facilitating encounters with dispersed ligand, as well as induction of a high‐affinity state. These two modalities of integrin activation by chemokines involve distinct signaling pathways in the cell, yet complement each other functionally, allowing binding of rolling cells under conditions of low as well as high ligand density. Recent data show that chemokines generate both pro‐ and anti‐adhesive intracellular signaling events, whose equilibrium is likely to be relevant to the kinetics of adhesion and de‐adhesion, and to cell movement during diapedesis and chemotaxis. Importantly, chemokines utilize different signaling mechanisms to modulate the activity of distinct integrin subtypes. These recent advances suggest that chemokines may regulate adhesive responses of immune cells based not only on patterns of chemokine receptor expression, but also on variable signaling pathways that can modulate the pro‐adhesive responses of leukocytes as a function of their differentiated state, and of the local microenvironment.
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Cites
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Ley, K., Laudanna, C., Cybulsky, M. I., & Nourshargh, S. (2007) · Nature Reviews Immunology · doi:10.1038/nri2156 · Cited by 4,354
Self-citationPathogen Recognition and Inflammatory Signaling in Innate Immune Defenses
Mogensen, T. H. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00046-08 · Cited by 3,111
Immune cell migration in inflammation: present and future therapeutic targets
Luster, A. D., Alon, R., & von Andrian, U. H. (2005) · Nature Immunology · doi:10.1038/ni1275 · Cited by 1,313
Toll-like receptors and cancer
Rakoff-Nahoum, S., & Medzhitov, R. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2541 · Cited by 925
Regulation of B-cell fate by antigen-receptor signals
Niiro, H., & Clark, E. A. (2002) · Nature Reviews Immunology · doi:10.1038/nri955 · Cited by 629
Metadata
- Authors
- Laudanna, C., Kim, J. Y., Constantin, G., & Butcher, E. C.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2002-08
- Volume
- 186
- Issue
- 1
- Pages
- 37-46
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2002293674
- Cited by
- 340
- References
- 60
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- Laudanna, C., Kim, J. Y., Constantin, G., & Butcher, E. C. (2002). Rapid leukocyte integrin activation by chemokines. Immunological Reviews. https://doi.org/10.1034/j.1600-065x.2002.18604.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
