Toll-like receptors and cancer
Abstract
Toll-like receptors (TLRs) are a family of pattern recognition receptors that are best-known for their role in host defence from infection. Emerging evidence also suggests that TLRs have an important role in maintaining tissue homeostasis by regulating the inflammatory and tissue repair responses to injury. The development of cancer has been associated with microbial infection, injury, inflammation and tissue repair. Here we discuss how the function of TLRs may relate to these processes in the context of carcinogenesis.
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TLRs are expressed in many cancer epithelial cells and can affect tumor growth.
“Besides the canonical pathogen protection functions of TLRs, they are also expressed in many cancer epithelial cells and can affect tumor growth [18].”
From Ligand dependent restoration of human TLR3 signaling and death in p53 mutant cells (2016) · cites this paper as [18]
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- Authors
- Rakoff-Nahoum, S., & Medzhitov, R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Rakoff-Nahoum, Seth
- Venue
- Nature Reviews Cancer
- Published
- 2008-12-04
- Volume
- 9
- Issue
- 1
- Pages
- 57-63
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2034028219
- Cited by
- 925
- References
- 8
- Citations by year
- 2026: 21 · 2025: 19 · 2024: 53 · 2023: 39 · 2022: 48 · 2021: 55 · 2020: 73 · 2019: 58 · 2018: 52 · 2017: 67 · 2016: 61 · 2015: 48 · 2014: 66 · 2013: 67 · 2012: 63
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- Toll-like receptors, carcinogenesis, pattern recognition receptors, inflammation, tissue repair, injuries, microbial infection, tissue homeostasis, host defense
- MeSH terms
- Animals, Cell Transformation, Neoplastic, Homeostasis, Humans, Immunologic Surveillance, Infections, Inflammation, Ligands, Neoplasm Proteins, Neoplasms, Regeneration, Wound Healing, Signal Transduction, T-Lymphocyte Subsets, Immunotherapy, Adoptive, Toll-Like Receptors, Mice, Myeloid Differentiation Factor 88
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