Cited by 1,313Chemokine receptors and signalingCell Adhesion Molecules ResearchMacrophage Migration Inhibitory Factor

Immune cell migration in inflammation: present and future therapeutic targets

Luster, Andrew D, Alon, Ronen, von Andrian, Ulrich H·2005·Nature Immunology

Abstract

The burgeoning field of leukocyte trafficking has created new and exciting opportunities in the clinic. Trafficking signals are being defined that finely control the movement of distinct subsets of immune cells into and out of specific tissues. Because the accumulation of leukocytes in tissues contributes to a wide variety of diseases, these 'molecular codes' have provided new targets for inhibiting tissue-specific inflammation, which have been confirmed in the clinic. However, immune cell migration is also critically important for the delivery of protective immune responses to tissues. Thus, the challenge for the future will be to identify the trafficking molecules that will most specifically inhibit the key subsets of cells that drive disease processes without affecting the migration and function of leukocytes required for protective immunity.

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Crossref · 10.1038/ni1275

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Authors
Luster, A. D., Alon, R., & von Andrian, U. H.
Affiliations
  • Harvard University (US)
  • Weizmann Institute of Science (IL)
Corresponding author
  • Luster, Andrew D
  • Alon, Ronen
Venue
Nature Immunology
Published
2005-11-17
Volume
6
Issue
12
Pages
1182-1190
ISSN
  • 1529-2908 (ISSN-L)
  • 1529-2916
OpenAlex
W2002148098
Cited by
1,313
References
97
Citations by year
2026: 21 · 2025: 64 · 2024: 66 · 2023: 70 · 2022: 53 · 2021: 49 · 2020: 44 · 2019: 46 · 2018: 48 · 2017: 69 · 2016: 66 · 2015: 60 · 2014: 75 · 2013: 73 · 2012: 75
FWCI
7.61
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Dana Foundation
  • Roche Organ Transplant Research Foundation
  • Israel Science Foundation
  • National Institutes of Health
Topics
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
Keywords
leukocyte migration, inflammation, chemokines, chemokine receptors, tissue-specific inflammation, therapeutic target, protective immunity, leukocyte homing
MeSH terms
Animals, Cell Movement, Humans, Immunotherapy, Inflammation

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