The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Modulation of Melanogenesis by Aloesin: A Competitive Inhibitor of Tyrosinase
Open accessAbstract
Aloesin, [2‐acetonyl‐8‐β‐d‐glucopyranosyl‐7‐hydroxy‐5‐methylchromone], a compound isolated from the Aloe plant, is shown in these studies to modulate melanogenesis via competitive inhibition of tyrosinase. Aloesin inhibits purified tyrosinase enzyme and specifically inhibits melanin production in vitro. Enzyme kinetics studies using normal human melanocyte cell lysates and cell‐based melanin production demonstrated that aloesin is a competitive inhibitor of tyrosinase from mushroom, human and murine sources. Tyrosine hydroxylase and 3,4‐dihydroxyphenylalanine (DOPA) oxidase activities of tyrosinase from normal human melanocyte cell lysates were inhibited by aloesin in a dose dependent manner. In a percutaneous absorption study a finite dose of aloesin penetrated the skin slowly and was recovered primarily in the surface wash. Aloesin shows promise as a pigmentation‐altering agent for cosmetic or therapeutic applications.
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Cites
Arbutin: mechanism of its depigmenting action in human melanocyte culture
Maeda, K., & Fukuda, M. (1996) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12357-4 · Cited by 533
Inhibition of Melanosome Transfer Results in Skin Lightening1
Seiberg, M., Paine, C., Sharlow, E., Eisinger, M., Shapiro, S. S., Andrade-Gordon, P., & Costanzo, M. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00035.x · Cited by 238
Cited by
Chemical and Instrumental Approaches to Treat Hyperpigmentation
Briganti, S., Camera, E., & Picardo, M. (2003) · Pigment Cell Research · doi:10.1034/j.1600-0749.2003.00029.x · Cited by 837
Hypopigmenting agents: an updated review on biological, chemical and clinical aspects
Solano, F., Briganti, S., Picardo, M., & Ghanem, G. (2006) · Pigment Cell Research · doi:10.1111/j.1600-0749.2006.00334.x · Cited by 696
Bioactive compounds from natural resources against skin aging
Mukherjee, P. K., Maity, N., Nema, N. K., & Sarkar, B. K. (2011) · Phytomedicine · doi:10.1016/j.phymed.2011.10.003 · Cited by 545
Survey and mechanism of skin depigmenting and lightening agents
Parvez, S., Kang, M., Chung, H., Cho, C., Hong, M., Shin, M., & Bae, H. (2006) · Phytotherapy Research · doi:10.1002/ptr.1954 · Cited by 403
Self-citationDraelos, Z. D. (2007) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2007.00144.x · Cited by 390
Metadata
- Authors
- Jones, K., Hughes, J., Hong, M., Jia, Q., & Orndorff, S.
- Venue
- Pigment Cell Research
- Publisher
- Wiley
- Published
- 2002-09-05
- Volume
- 15
- Issue
- 5
- Pages
- 335-340
- ISSN
- 0893-5785 (ISSN-L)
- 1600-0749
- OpenAlex
- W2133095097
- Cited by
- 209
- References
- 2
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Jones, K., Hughes, J., Hong, M., Jia, Q., & Orndorff, S. (2002). Modulation of Melanogenesis by Aloesin: A Competitive Inhibitor of Tyrosinase. Pigment Cell Research. https://doi.org/10.1034/j.1600-0749.2002.02014.x
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