CoChat
Sign Up
Cited by 41Pharmacogenetics and Drug MetabolismDrug Transport and Resistance MechanismsComputational Drug Discovery Methods

In vitro Tests for Predicting Drug‐Drug Interactions: The Need for Validated Procedures

Kremers, Pierre·2002·Pharmacology & Toxicology
DOI 10.1034/j.1600-0773.2002.910501.x
Open this paper in CoChat — free account

Abstract

Over the past decade, the prediction of drug-drug interactions from in vitro studies has become a rapidly expanding field of research. Numerous papers and excellent review articles (Bertz & Granneman 1997; Ito et al. 1998a & b; Lin 2000; Bachmann & Ghosh 2001; Ekins & Wrighton 2001; Weaver 2001) have been published in this area. Yet like any new and fast-growing subject, this one has been developing with some confusion and without any real, efficient organisation. Depending on the drug tested, the models and extrapolation parameters used, etc., results and conclusions may vary widely from study to study (von Moltke et al. 1998; Weaver 2001). Several authors have called for validation of these procedures (Rodrigues et al. 2001; Kummar & Surapaneni 2001; Pelkonen et al. 2001a & b; Kremers 2002), and regulatory authorities intend to require better traceability and reliability (FDA & EMEA guidelines). A systematic and reliable approach is needed also to allow such protocols to be incorporated into early screening for potential drugs and new chemical entities. There is certainly a great need to standardise these studies and to verify their conclusions, but is true validation possible in this field? The main purpose of the present paper is to discuss this issue and to examine what is possible and what is needed to improve the quality of predictions made from in vitro experiments.

Integrity signals

Registry

Crossref · 10.1034/j.1600-0773.2002.910501.x

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Concomitant administration of phenelzine and ginseng resulted in headache, tremulousness, and manic episodes.

    “The concomitant administration of the two resulted in headache, tremulousness, and manic episodes [98]”

    From Phytotherapy: A promising approach for the treatment of Alzheimer's disease (2022) · cites this paper as [98]

  • Induction or inhibition of drugs' pharmacological actions by herbs is facilitated by hepatic enzymes such as cytochrome P450 and/or the drug transporter P-glycoprotein.

    “The induction or inhibition of drugs' pharmacological actions by herbs is facilitated by hepatic enzymes such as cytochrome P450 (CYP) and/or the drug transporter, P-glycoprotein (P-gp).”

    From Phytotherapy: A promising approach for the treatment of Alzheimer's disease (2022) · cites this paper as [98]

  • P-gp and CYP3A are significantly present in the villus tip of enterocytes, the major site of orally taken medications.

    “P-gp and CYP3A are significantly present in the villus tip of enterocytes, which is the major site of medications taken through the oral route.”

    From Phytotherapy: A promising approach for the treatment of Alzheimer's disease (2022) · cites this paper as [98]

Cites

Flagged first, then by citations

1 of the 56 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Kremers, P.
Affiliations
University of Liège (BE)
Corresponding author
Kremers, Pierre
Venue
Pharmacology & Toxicology
Publisher
Wiley
Published
2002-11
Volume
91
Issue
5
Pages
209-217
ISSN
0901-9928 (ISSN-L)
DOI
10.1034/j.1600-0773.2002.910501.x
OpenAlex
W2049141234
Cited by
41
References
56
Citations by year
2026: 2 · 2025: 2 · 2023: 2 · 2022: 2 · 2021: 6 · 2020: 1 · 2019: 3 · 2014: 1 · 2012: 2
FWCI
0.33
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 74 d)
Locations
  • Pharmacology & Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Physical Sciences › Computer Science › Computational Theory and Mathematics › Computational Drug Discovery Methods
Keywords
drug-drug interactions, in vitro prediction, cytochrome P450 inhibition, drug screening, new chemical entities, regulatory guidelines
MeSH terms
Clinical Trials as Topic, Drug Interactions, Pharmaceutical Preparations, Forecasting, Humans, Research Design, Drug Design, Reproducibility of Results, Clinical Laboratory Techniques, Drug-Related Side Effects and Adverse Reactions, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review