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Dominant IL‐10 and TGF‐β mRNA Expression in γδT Cells of Human Early Pregnancy Decidua Suggests Immunoregulatory Potential
Open accessAbstract
PROBLEM: To examine the cytokine gene expression in γδT‐cells from human early pregnancy decidua. METHOD OF STUDY: The cytokine messenger RNA (mRNA) expression in isolated decidual T‐cell receptor (TCR)γδ+/CD56+and TCRγδ single positive cells was investigated with a panel of cytokine primers and probes selected to distinguish between T helper (Th)1, Th2, Th3 and regulatory T‐cells (Tr1) type of immune response using real‐time quantitative reverse transcriptase‐polymerase chain reaction (RT‐PCR). RESULTS: TCRγδ+/CD56+cells express almost exclusively the immunosuppressive cytokines interleukin‐10 (IL‐10) and transforming growth factor (TGF)‐β. The TCRγδ single positive cells enhance their transcription of IL‐10 and TGF‐β, compared with the TCRγδ+/CD56+cells and additionally express mRNA for IL‐1β and IL‐6. CONCLUSIONS: The present findings suggest that γδT cells in normal pregnancy create a cytokine milieu promoting immunotolerance to the fetus. We hypothesize that through the production of the immunosuppressive cytokines IL‐10 and/or TGF‐β the γδT cells could function directly as regulatory T cells or induce the differentiation of Th0 TCRαβ+cells into regulatory/suppresser cells.
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Wegmann, T. G., Lin, H., Guilbert, L., & Mosmann, T. R. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90235-d · Cited by 2,852
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Hedlund, M., Stenqvist, A.-C., Nagaeva, O., Kjellberg, L., Wulff, M., Baranov, V., & Mincheva-Nilsson, L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803477 · Cited by 332
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Metadata
- Authors
- NAGAEVA, O., JONSSON, L., & MINCHEVA‐NILSSON, L.
- Venue
- American Journal of Reproductive Immunology
- Publisher
- Wiley
- Published
- 2002-06-19
- Volume
- 48
- Issue
- 1
- Pages
- 9-17
- ISSN
- 0271-7352 (ISSN-L)
- 1046-7408
- 1600-0897
- OpenAlex
- W1482475506
- Cited by
- 164
- References
- 1
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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- NAGAEVA, O., JONSSON, L., & MINCHEVA‐NILSSON, L. (2002). Dominant IL‐10 and TGF‐β mRNA Expression in γδT Cells of Human Early Pregnancy Decidua Suggests Immunoregulatory Potential. American Journal of Reproductive Immunology. https://doi.org/10.1034/j.1600-0897.2002.01131.x
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