The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.
γδ T Cells Link Innate and Adaptive Immune Responses
Abstract
While most T cells use a CD3-associated alpha/beta T cell receptor as antigen recognition structure, a second population of T cells expresses the alternative gamma/delta T cell receptor. gamma/delta T cells are a minor population in the peripheral blood but constitute a major population among intestinal intraepithelial lymphocytes. Most gamma/delta T cells recognize ligands which are fundamentally different from the short peptides that are seen by alpha/beta T cells in the context of MHC class I or class II molecules. Thus, human Vdelta2 T cells recognize small bacterial phosphoantigens, alkylamines and synthetic aminobisphosphonates, whereas Vdelta1 T cells recognize stress-inducible MHC-related molecules MICA/B as well as several other ligands. At the functional level, gamma/delta T cells rapidly produce a variety of cytokines and usually exert potent cytotoxic activity, also towards many tumor cells. In this article, we discuss the role of gamma/delta T cells as a bridge between the innate and the adaptive immune system, based on the interpretation that gamma/delta T cells use their T cell receptor as a pattern recognition receptor. Our increasing understanding of the ligand recognition and activation mechanisms of gamma/delta T cells also opens new perspectives for the development of gamma/delta T cell-based immunotherapies.
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Overview of methodologies for T-cell receptor repertoire analysis
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Metadata
- Authors
- Holtmeier, W., & Kabelitz, D.
- Venue
- Chemical Immunology and Allergy
- Publisher
- KARGER
- Published
- 2005
- Volume
- 86
- Pages
- 151-183
- OpenAlex
- W2052160940
- Cited by
- 305
- References
- 133
- FWCI
- 12.89
- Type
- book chapter
- Language
- en
- Open access
- closed
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