The eating paradox: How we tolerate food.

Abstract

It is hypothesized that food, which is certainly a necessary commodity with powerful positive reinforcing qualities, also provides a potential threat to organisms, including humans. The act of eating, although necessary for the provision of energy, is a particularly disruptive event in a homeostatic sense. Just as humans learn responses to help them tolerate the administration of dangerous drugs, so do they learn to make anticipatory responses that help minimize the impact of meals on the body, to limit the amount of food consumed within any individual meal, to recruit several parts of the protective stress-response system while meals are being processed, and to limit postprandial behaviors so as to minimize the possibility of disrupting homeostatic systems even more. It is further hypothesized that defenses against eating too much may become activated inappropriately and contribute to clinical problems such as reactive hypoglycemia.

Cites (210)

1. The Pharmacological Basis of Therapeutics
   1976 · American Journal of Health-System Pharmacy
2. The Stress of Life
   Hans Selye · 1956 · Medical Entomology and Zoology
3. Bioenergetics and Growth.
   Brody, Samuel, Lardy, Henry A. · 1946 · The Journal of Physical Chemistry
4. Handbook of Psychopharmacology
   1988 · Springer eBooks
5. Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices
   Armstrong, Bruce, Doll, Richard · 1975 · International Journal of Cancer
6. THE DIET AND 15-YEAR DEATH RATE IN THE SEVEN COUNTRIES STUDY
   KEYS, ANCEL, MIENOTTI, ALESSANDRO, KARVONEN, MARITI J., ARAVANIS, CHRIST, BLACKBURN, HENRY, BUZINA, RATKO, DJORDJEVIC, B. S., DONTAS, A. S., FIDANZA, FLAMINIO, KEYS, MARGARET H. et al. · 1986 · American Journal of Epidemiology
7. A role for brown adipose tissue in diet-induced thermogenesis
   Rothwell, Nancy J., Stock, Michael J. · 1979 · Nature
8. Physiological Role of Pleasure: A stimulus can feel pleasant or unpleasant depending upon its usefulness as determined by internal signals.
   Cabanac, Michel · 1971 · Science
9. Textbook of Endocrinology
   1952 · Diabetes
10. [Drug addiction and drug abuse].
    W. Feuerlein · 1969 · PubMed

Show all 210 references

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