Evidence for a dissociation between perceptual and conceptual priming in Alzheimer's disease.

Abstract

The status of perceptual priming and word-completion priming in patients with Alzheimer's disease (AD) was examined. Experiment 1 established the reliability of the perceptual priming measure in normal subjects. In Experiment 2, AD patients showed a normal magnitude of perceptual priming. In Experiment 3, a single group of AD patients showed a normal magnitude of perceptual priming and impaired word-completion priming. Further, word-completion priming, but not perceptual priming, was correlated with verbal fluency performance in AD. These results suggest a dissociation between two components of verbal priming. Perceptual priming may reflect the operation of a structural-perceptual memory system mediated by occipital lobe regions relatively spared in AD. Word-completion priming may reflect the operation of a lexical-semantic memory system mediated by temporoparietal lobe regions compromised in AD.

Cites (3)

1. The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects
   Blessed, G., Tomlinson, B. E., Roth, Martin · 1968 · British Journal of Psychiatry
2. Preserved Learning and Retention of Pattern-Analyzing Skill in Amnesia: Dissociation of Knowing How and Knowing That
   Cohen, Neal J., Squire, Larry R. · 1980 · Science
3. Further analysis of the hippocampal amnesic syndrome: 14-year follow-up study of H.M.
   Milner, Brenda, Corkin, Suzanne, Teuber, H.-L. · 1968 · Neuropsychologia

Show all 3 references

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