What's new with the amnesic patient H.M.?
Abstract
H.M. became amnesic in 1953. Since that time, nearly 100 investigators, first at the Montreal Neurological Institute and since 1966 at the Massachusetts Institute of Technology, have participated in studying him. We all understand the rare opportunity we have had to work with him, and we are grateful for his dedication to research. He has taught us a great deal about the cognitive and neural organization of memory. We are in his debt.
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Integrity of hippocampal circuitry is a prerequisite for retaining an episode as well as spatial and temporal context information in memory for more than 15 min.
“Integrity of hippocampal circuitry is a prerequisite for retaining an episode as well as spatial and temporal context information in memory for more than 15 min (231, 418).”
From About Sleep's Role in Memory (2013) · cites this paper as [231]
The two-stage model has received strong support from lesion studies, indicating that lesions of the hippocampus abolish the ability to acquire new declarative memory and simultaneously produce a temporally graded retrograde amnesia where older memories remain intact.
“For the declarative memory system, the two-stage model has received strong support from lesion studies, indicating that lesions of the hippocampus abolish the ability to acquire new declarative memory and simultaneously produce a temporally graded retrograde amnesia where older memories remain intact (231,418).”
From About Sleep's Role in Memory (2013) · cites this paper as [231]
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- Authors
- Corkin, S.
- Affiliations
- Massachusetts Institute of Technology (US)
- Corresponding author
- Corkin, Suzanne
- Venue
- Nature Reviews Neuroscience
- Published
- 2002-02
- Volume
- 3
- Issue
- 2
- Pages
- 153-160
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W1562191902
- Cited by
- 726
- References
- 7
- Citations by year
- 2026: 15 · 2025: 23 · 2024: 32 · 2023: 22 · 2022: 33 · 2021: 24 · 2020: 31 · 2019: 92 · 2018: 21 · 2017: 50 · 2016: 29 · 2015: 28 · 2014: 32 · 2013: 42 · 2012: 41
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Neurology › Neurology and Historical Studies
- Keywords
- Henry Molaison, amnesia, memory systems, history of memory research
- MeSH terms
- Aged, Amnesia, Epilepsy, Temporal Lobe, Hippocampus, Humans, Longitudinal Studies, Male, Memory, Nerve Net, Neuropsychological Tests, Neurosurgical Procedures, Recovery of Function
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