The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Impact of comorbid depressive symptoms on neuropsychological performance in obsessive-compulsive disorder
Abstract
There is indirect evidence from previous research that several executive disturbances in obsessive-compulsive disorder (OCD) are mediated by comorbid depressive symptoms. For the present study, the authors investigated whether OCD patients with elevated Hamilton Rating Scale for Depression (HRSD) scores would exhibit deficits in tasks sensitive to the medial and dorsolateral frontal cortex as well as other executive tasks. The 36 OCD patients were split along the median according to their HRSD scores and compared with matched control subjects. Patients with high HRSD scores performed significantly worse than control subjects and patients with low HRSD scores on the Wisconsin Card Sorting Test, the Trail-Making Test (TMT, Part B), and the TMT difference score. Moreover, patients with high HRSD scores exhibited deficits on a (creative) verbal fluency task. It is suggested that comorbid depressive symptoms may have artificially inflated some executive deficit scores in previous studies.
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“Moritz et al. (2001) found that while OCD patients with comorbid depressive symptoms displayed cognitive impairment, this was not the case for patients with low depression symptoms relative to healthy controls.”
From Obsessive-compulsive disorder: Etiology, neuropathology, and cognitive dysfunction (2023) · cites this paper as Moritz et al., 2001
In the citing paper
“On the other hand, symptoms of attention deficit-hyperactivity disorder and depressive symptoms are common in OCD (Pallanti et al., 2011) and may contribute to neuropsychological deficits (Brem et al., 2014; Moritz et al., 2001).”
From Externally orienting cues improve cognitive control in OCD (2024) · cites this paper as Moritz et al., 2001
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“For instance, Moritz et al. (2001) found that while OCD patients with comorbid depressive symptoms displayed cognitive impairment, this was not the case for patients with low depression symptoms relative to healthy controls.”
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Metadata
- Authors
- Moritz, S., Birkner, C., Kloss, M., Jacobsen, D., Fricke, S., Böthern, A., & Hand, I.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- Venue
- Journal of Abnormal Psychology
- Published
- 2001-11
- Volume
- 110
- Issue
- 4
- Pages
- 653-657
- ISSN
- 0021-843X (ISSN-L)
- 1939-1846
- OpenAlex
- W1982197723
- Cited by
- 138
- References
- 26
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 6 · 2016: 2 · 2015: 11 · 2014: 10 · 2013: 10 · 2012: 8
- FWCI
- 7.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Abnormal Psychology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- obsessive-compulsive disorder, depressive symptoms, comorbidities, executive function, neuropsychological performance, frontal cortex, dorsolateral prefrontal cortex, medial prefrontal cortex, verbal fluency, Trail Making Test, Wisconsin Card Sorting Test, Hamilton Depression Rating Scale
- MeSH terms
- Adult, Cognition Disorders, Depression, Female, Humans, Male, Neuropsychological Tests, Obsessive-Compulsive Disorder, Severity of Illness Index
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