Cited by 302Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

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What psychological process mediates feeding evoked by electrical stimulation of the lateral hypothalamus?

Berridge, Kent C., Valenstein, Elliot S.·1991·Behavioral Neuroscience

DOI 10.1037/0735-7044.105.1.3

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Abstract

Because electrical stimulation of the lateral hypothalamus (ESLH) can elicit both feeding and reward, most investigators have concluded that stimulation does not evoke the aversive cues associated with hunger. It has been hypothesized, instead, that ESLH primes ingestion by evoking pleasurable taste sensations. A direct taste of this hedonic hypothesis was undertaken in rats that showed stimulus-bound feeding. Contrary to the prediction, it was found that the taste reactions (gapes, tongue protrusions, etc.) during ESLH were more aversive than hedonic. It is suggested that the stimulation influences behavior by potentiating the salience, but not the hedonic value, of external stimuli. The advantages of this incentive salience hypothesis are that it circumvents the need to postulate a hedonic sensory experience during stimulation and that it can explain how evoked feeding may switch to other behaviors when conditions are altered.

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“And this is not because the system engenders feelings of sensory hedonics, as many behavioral investigators originally entertained (e.g., Wise, 1982; Berridge & Valenstein, 1991), but states of positive enthusiasm, that normally accompany the appetitive-foraging phase of behavior in our species, as…”
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“The effect of BSR on these behaviors is probably due to potentiated salience of external stimuli rather than increased hedonic value (Berridge and Valenstein, 1991).”
Background
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“This explanation is attractive because of the similarities between the behavioural effects of electrical stimulation of lateral hypothalamus and GABA-ergic stimulation of the accumbens [2] and the arguments in favour of an incentive-based explanation in the former case [27].”
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“2005; Berridge and Valenstein 1991).”
Self-citation
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“This system has been linked to general behavioral activation, forms of “ wanting ” (Berridge & Valenstein, 1991; Robinson et al., 2015), the persistence of behavior, and approach behavior (Panksepp & Biven, 2012).”
Background
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“This is consistent with studies showing that the two are mediated by distinct neural systems (Aharon et al., 2001; Berridge, 1996, 2000; Berridge & Robinson, 1998; Berridge, Robinson, & Aldridge, 2009; Berridge & Valenstein, 1991).”
Result
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Authors: Berridge, K. C., & Valenstein, E. S.
Affiliations: University of Michigan (US)
ORCID: Berridge, Kent C.
Venue: Behavioral Neuroscience
Publisher: American Psychological Association (APA)
Published: 1991
Volume: 105
Issue: 1
Pages: 3-14
ISSN: 0735-7044 (ISSN-L)
1939-0084
DOI: 10.1037/0735-7044.105.1.3
OpenAlex: W2139823869
Cited by: 302
References: 0
Citations by year: 2026: 1 · 2025: 5 · 2024: 5 · 2023: 20 · 2022: 4 · 2021: 4 · 2020: 52 · 2019: 45 · 2018: 9 · 2017: 4 · 2016: 12 · 2015: 14 · 2014: 11 · 2013: 6 · 2012: 6
FWCI: 2.84
Type: journal article
Language: en
Open access: closed
Locations: Behavioral Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (NS-23959, R01NS023959)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: lateral hypothalamus, electrical stimulation, incentive salience, hunger, reward
MeSH terms: Animals, Appetite, Arousal, Avoidance Learning, Brain Mapping, Brain Stem, Dopamine, Electric Stimulation, Feeding Behavior, Hypothalamic Area, Lateral, Male, Motivation, Motor Activity, Neural Pathways, Neurons, Taste, Rats

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What psychological process mediates feeding evoked by electrical stimulation of the lateral hypothalamus?

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