Noninteractive effects of diazepam and amygdaloid lesions in two animal models of anxiety.
Abstract
The role of the amygdala in mediating the anxiolytic effects of diazepam was examined in two models of rat anxiety. As in our previous experiments, amygdaloid lesions by themselves did not increase rats' exploration of the open arms of the elevated plus-maze or decrease rats' burying of an electrified probe in the shock-probe burying test. However, amygdaloid lesions did increase rats' shock-probe contacts. Diazepam (2 mg/kg) increased open-arm activity and decreased burying behavior to an equal extent in sham-lesioned and amygdala-lesioned rats and had no significant effect on the facilitation of probe contacts induced by amygdaloid lesions. These results suggest that many of the anxiolytic effects of benzodiazepines are not mediated by the amygdala.
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Benzodiazepines reduce burying of shock-associated objects.
“to reduce burying of shock-associated objects (Kopchia et al, 1992; Treit et al, 1993b).”
From Phasic vs Sustained Fear in Rats and Humans: Role of the Extended Amygdala in Fear vs Anxiety (2010) · cites this paper as Treit et al, 1993b
In several cases, lesions of the central amygdala did not block the anxiolytic effects of benzodiazepines, although central amygdala lesions tended to have anxiolytic effects on their own.
“in several cases, lesions of the CeA did not block these anxiolytic effects of benzodiazepines, although the CeA lesions tended to have anxiolytic effects on their own (Kopchia et al, 1992; Yadin et al, 1991; Treit et al, 1993b).”
From Phasic vs Sustained Fear in Rats and Humans: Role of the Extended Amygdala in Fear vs Anxiety (2010) · cites this paper as Treit et al, 1993b
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- Authors
- Treit, D., Pesold, C., & Rotzinger, S.
- Affiliations
- University of Alberta (CA)
- ORCID
- Rotzinger, Susan
- Venue
- Behavioral Neuroscience
- Published
- 1993
- Volume
- 107
- Issue
- 6
- Pages
- 1099-1105
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2054109249
- Cited by
- 78
- References
- 35
- Citations by year
- 2024: 22 · 2021: 1 · 2015: 1 · 2014: 1
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- diazepam, amygdala, anxiolytic effects, benzodiazepines, anxiety models, elevated plus maze, open arm exploration, rats
- MeSH terms
- Amygdala, Animals, Anxiety, Arousal, Avoidance Learning, Brain Mapping, Diazepam, Discrimination Learning, Exploratory Behavior, Male, Motor Activity, Orientation, Social Environment, Rats, Sprague-Dawley, Rats
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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