A comparison of anxiolytic and nonanxiolytic agents in the shock-probe/burying test for anxiolytics
Abstract
The effects of IP midazolam (1.0-3.0 mg/kg), pentobarbital (10-20 mg/kg), ethanol (500-2000 mg/kg), scopolamine (0.05-1.25 mg/kg), chlorpromazine (0.5-5.0 mg/kg), yohimbine (0.5-2.0 mg/kg), and pentylene-tetrazol (5.0-20.0 mg/kg) were compared in the shock-probe/burying test. Consistent with results found previously for chlordiazepoxide and buspirone, the anxiolytic agents midazolam and pentobarbital decreased rats' burying behavior toward a continuously electrified (2 mA) shock-probe, and increased the number of contact-induced probe-shocks rats received. A concurrent decrease in probe-burying and increase in probe-shocks was not reliably observed after ethanol, scopolamine, chlorpromazine, yohimbine, or pentylenetetrazol. Although most of these nonanxiolytic agents produced some suppression of burying behavior at high doses, none of these drugs induced a significant increase in probe-shocks. In fact, pentylenetetrazol, which is believed to be anxiogenic, produced a significant reduction in probe-shocks. Yohimbine, another putative anxiogenic agent, was not active in the present test. In summary, concurrent increases in probe-shocks and decreases in probe-burying seem to be characteristic effects of clinically useful anxiolytic agents, which distinguish them from nonanxiolytic agents.
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The shock-probe burying test is a well-validated animal model of anxiety.
“the shock-probe burying test, a well-validated animal model of anxiety (Pinel and Treit, 1978; Treit, 1990; Everts and Koolhaas, 1999; Perez de la Mora et al., 2006; McNeal et al., 2018).”
From Evidence for the existence of facilitatory interactions between the dopamine D2 receptor and the oxytocin receptor in the amygdala of the rat relevance for anxiolytic actions (2023) · cites this paper as Treit, 1990
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Emilien, G., Dinan, T. G., Lepola, U. M., & Durlach, C. (2002) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8157-9_9
- Authors
- Treit, D.
- Affiliations
- University of Alberta (CA)
- Corresponding author
- Treit, Dallas
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 1990-05
- Volume
- 36
- Issue
- 1
- Pages
- 203-205
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2035841543
- Cited by
- 86
- References
- 11
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- anxiolytics, midazolam, pentobarbital, ethanol, scopolamine, chlorpromazine, yohimbine, pentylenetetrazole, burying behavior, rats
- MeSH terms
- Animals, Anxiety, Behavior, Animal, Male, Rats, Inbred Strains, Anti-Anxiety Agents, Rats
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