The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Hippocampal lesions cause learning deficits in inbred mice in the Morris water maze and conditioned-fear task
Abstract
This study examined the effect of hippocampal lesions on acquisition of the Morris water maze and conditioned-fear task in inbred mice. C57BL/6J, DBA/2J, and B6D2F1 hybrid mice were given hippocampal lesions or sham surgery and then tested. The lesioned C57BL/6J and B6D2F1 mice failed to learn the Morris task relative to sham-operated controls, and no DBA group learned the task. In the contextual component of conditioned fear, lesions decreased freezing in all strains. But the lesions only affected freezing to the conditioned stimulus in the DBA/2J and B6D2F1 strains. These data demonstrate that C57BL/6J and B6D2F1 mice use the hippocampus to solve the Morris water maze and conditioned-fear task, and the DBA mice use the hippocampus, to some degree, in the conditioned-fear task.
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In the citing paper
“In addition, the finding that withdrawal disrupted contextual but not cued fear conditioning adds to a growing literature that, at least in the mouse model, nicotine withdrawal disrupts hippocampus-dependent learning but not hippocampus-independent learning as contextual fear conditioning requires the hippocampus whereas cued fear conditioning does not (Fanselow et al., 1994; Logue et al., 1997;”
From The duration of nicotine withdrawal-associated deficits in contextual fear conditioning parallels changes in hippocampal high affinity nicotinic acetylcholine receptor upregulation (2012) · cites this paper as Logue et al., 1997
In the citing paper
“In addition, the finding that withdrawal disrupted contextual but not cued fear conditioning adds to a growing literature that, at least in the mouse model, nicotine withdrawal disrupts hippocampus-dependent learning but not hippocampus-independent learning as contextual fear conditioning requires the hippocampus whereas cued fear conditioning does not (Fanselow et al., 1994; Logue et al., 1997;”
From The duration of nicotine withdrawal-associated deficits in contextual fear conditioning parallels changes in hippocampal high affinity nicotinic acetylcholine receptor upregulation (2012) · cites this paper as Logue et al., 1997
In the citing paper
“fear conditioning requires the hippocampus whereas cued fear conditioning does not (Fanselow et al., 1994; Logue et al., 1997; Phillips and Ledoux, 1992).”
From The duration of nicotine withdrawal-associated deficits in contextual fear conditioning parallels changes in hippocampal high affinity nicotinic acetylcholine receptor upregulation (2012) · cites this paper as Logue et al., 1997
Citations
Cites
Place navigation impaired in rats with hippocampal lesions
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292
Spatial localization does not require the presence of local cues
Morris, R. G. M. (1981) · Learning and Motivation · doi:10.1016/0023-9690(81)90020-5 · Cited by 2,699
Modality-Specific Retrograde Amnesia of Fear
Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483
The amygdala: Neurobiological aspects of emotion, memory, and mental dysfunction.
Aggleton, J. P. (1992) · Wiley-Liss eBooks · Cited by 1,536
Impaired Spatial Learning in α-Calcium-Calmodulin Kinase II Mutant Mice
Silva, A. J., Paylor, R. E., Wehner, J. M., & Tonegawa, S. (1992) · Science · doi:10.1126/science.1321493 · Cited by 1,366
Self-citationSutherland, R. J., & Rudy, J. W. (1989) · Psychobiology · doi:10.3758/bf03337828 · Cited by 970
A perceptual-defensive-recuperative model of fear and pain
Bolles, R. C., & Fanselow, M. S. (1980) · Behavioral and Brain Sciences · doi:10.1017/s0140525x0000491x · Cited by 840
Hippocampal representation in place learning
Eichenbaum, H., Stewart, C., & Morris, R. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-11-03531.1990 · Cited by 803
(1992) · Cited by 626
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Sorted by citations
da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,015
Applications of the Morris water maze in the study of learning and memory
D’Hooge, R., & Deyn, P. P. D. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00067-4 · Cited by 2,083
Holcomb, L., Gordon, M. N., McGowan, E., Yu, X., Benkovic, S., Jantzen, P., Wright, K., Saad, I., Mueller, R., Morgan, D., et al. (1998) · Nature Medicine · doi:10.1038/nm0198-097 · Cited by 1,386
Essential Role for TrkB Receptors in Hippocampus-Mediated Learning
Minichiello, L., Korte, M., Wolfer, D., Kühn, R., Unsicker, K., Cestari, V., Rossi-Arnaud, C., Lipp, H.-P., Bonhoeffer, T., & Klein, R. (1999) · Neuron · doi:10.1016/s0896-6273(00)80853-3 · Cited by 799
Raber, J., Rola, R., LeFevour, A., Morhardt, D. R., Curley, J., Mizumatsu, S., VandenBerg, S. R., & Fike, J. R. (2004) · Radiation Research · doi:10.1667/rr3206 · Cited by 721
Metadata
- Authors
- Logue, S. F., Paylor, R., & Wehner, J. M.
- Affiliations
- University of Colorado Boulder (US)
- Venue
- Behavioral Neuroscience
- Published
- 1997-02
- Volume
- 111
- Issue
- 1
- Pages
- 104-113
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2088024567
- Cited by
- 385
- References
- 37
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 7 · 2023: 4 · 2022: 6 · 2021: 5 · 2020: 7 · 2019: 11 · 2018: 8 · 2017: 5 · 2016: 17 · 2015: 12 · 2014: 24 · 2013: 17 · 2012: 21
- FWCI
- 12.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh048663-05)
- National Institute of Mental Health (MH-48663)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (5T32HD-07289, T32HD007289)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- hippocampal lesions, hippocampus, spatial learning, Morris water maze, fear conditioning, contextual fear, freezing behavior, inbred mouse strains, C57BL/6J mice, DBA/2J, strain differences, learning deficits
- MeSH terms
- Animals, Association Learning, Cerebral Cortex, Conditioning, Classical, Escape Reaction, Fear, Hippocampus, Male, Mice, Inbred Strains, Motor Activity, Neural Pathways, Problem Solving, Mental Recall, Species Specificity, Maze Learning, Mice
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