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Cited by 315Obsessive-Compulsive Spectrum DisordersNeurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatment

Quinpirole induces compulsive checking behavior in rats: A potential animal model of obsessive-compulsive disorder (OCD).

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Szechtman, Henry, Sulis, William, Eilam, David·1998·Behavioral Neuroscience
DOI 10.1037/0735-7044.112.6.1475
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Abstract

Rats treated chronically with the dopamine agonist quinpirole (0.5 mg/kg, twice weekly x 10) met 5 criteria for performance of compulsive checking. Specifically, in a large open-field with single small objects in 4 of 25 locales, quinpirole rats revisited two places/objects excessively often and rapidly, compared with other locations in the environment or saline controls. They performed a ritual-like set of behavioral acts at these two places/objects and stopped in relatively few locales before returning to the preferred places/objects. Finally, they shifted their behavior to a new location when the object was moved there. Clomipramine (10 mg/kg, daily) postponed but did not prevent the development of the quinpirole effect. Quinpirole-induced compulsive checking may be an exaggeration of normal checking of home site in rats. Results suggest an animal model of obsessive-compulsive disorder and a role for dopamine in this disorder.

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  • Dopamine agonists acting on the basal ganglia can generate OCD-like behaviors in animals and humans.

    “dopamine agonists acting on the basal ganglia can generate OCD‐like behaviors in both animals (Szechtman et al., 1998), and humans (Borcherding et al., 1990)”

    From Obsessive-compulsive disorder: Etiology, neuropathology, and cognitive dysfunction (2023) · cites this paper as Szechtman et al., 1998

    The Abstract reports that chronic treatment with the dopamine agonist quinpirole induced compulsive checking in rats, supporting the animal-behavior part of the claim. The paper does not establish that the agonist acted on the basal ganglia to produce that behavior; the only matching mention of basal ganglia in our copy is a reference title. The human-behavior part is attributed to a different citation in the citing sentence and is not judged here. (LLM, conf=0.86)

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Research works printed but not linked: 30

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Authors
Szechtman, H., Sulis, W., & Eilam, D.
Affiliations
  • McMaster University (CA)
  • Tel Aviv University (IL)
ORCID
Venue
Behavioral Neuroscience
Publisher
American Psychological Association (APA)
Published
1998
Volume
112
Issue
6
Pages
1475-1485
ISSN
  • 0735-7044 (ISSN-L)
  • 1939-0084
DOI
10.1037/0735-7044.112.6.1475
OpenAlex
W2018376764
Cited by
315
References
0
Citations by year
2026: 9 · 2025: 5 · 2024: 9 · 2023: 12 · 2022: 9 · 2021: 13 · 2020: 17 · 2019: 20 · 2018: 6 · 2017: 14 · 2016: 13 · 2015: 15 · 2014: 16 · 2013: 10 · 2012: 19
FWCI
5.63
Type
journal article
Language
en
Open access
Locations
  • Behavioral Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • MacSphere (McMaster University) (submittedVersion)
  • MacSphere (McMaster University)
Funders
  • Medical Research Council Canada
  • Medical Research Council
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
quinpirole, compulsive checking, obsessive-compulsive disorder, animal models, dopamine agonists, clomipramine, compulsive behavior, rats
MeSH terms
Animals, Clomipramine, Disease Models, Animal, Male, Obsessive-Compulsive Disorder, Orientation, Stereotyped Behavior, Selective Serotonin Reuptake Inhibitors, Dopamine Agonists, Quinpirole, Rats, Long-Evans, Rats

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