A closer look to neural pathways and psychopharmacology of obsessive compulsive disorder
Open accessAbstract
The intricate neural pathways involved in obsessive-compulsive disorder (OCD) affect areas of our brain that control executive functioning, organization, and planning. OCD is a chronic condition that can be debilitating, afflicting millions of people worldwide. The lifetime prevalence of OCD in the US is 2.3%. OCD is predominantly characterized by obsessions consisting of intrusive and unwanted thoughts, often with impulses that are strongly associated with anxiety. Compulsions with OCD encompass repetitive behaviors or mental acts to satisfy their afflicted obsessions or impulses. While these factors can be unique to each individual, it has been widely established that the etiology of OCD is complex as it relates to neuronal pathways, psychopharmacology, and brain chemistry involved and warrants further exploration.
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We cannot exclude the possibility that the competing habit was not enabling the performance of a compulsion.
“Although there is evidence for similar competing responses being employed in treatment [70,71] and for a general neural domain of compulsions, whereby similar brain areas are active regardless of behavioural presentation [72], we cannot exclude the possibility that the competing habit was not enabling the performance of a compulsion.”
From Habit as a therapeutic component in psychological treatment for obsessive-compulsive disorder: A randomised controlled feasibility study. (2026) · cites this paper as [72]
Citation [72] is attached to the claim about a general neural domain of compulsions, not to the authors’ uncertainty about their competing habit. The Pathways section describes a CSTC loop as a core mechanism in OCD, supporting some shared circuitry, but also says that different presentations of obsessions and compulsions may involve different neuronal pathways. It therefore does not establish that similar brain areas are active regardless of behavioral presentation. (LLM, conf=0.84)
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- Authors
- Gargano, S. P., Santos, M. G., Taylor, S. M., & Pastis, I.
- Affiliations
- East Carolina University (US)
- Corresponding author
- Santos, Melody G.
- Venue
- Frontiers in Behavioral Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2023-11-16
- Volume
- 17
- Pages
- 1282246-1282246
- ISSN
- 1662-5153 (ISSN-L)
- PMC
- PMC10687174
- OpenAlex
- W4388733798
- Cited by
- 18
- References
- 168
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 5
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Behavioral Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- The Scholarship East Carolina University's Institutional Repository (East Carolina University) (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- obsessive-compulsive disorder, neural pathways, psychopharmacology, obsession, compulsive behavior, executive function, anxiety, neurochemistry
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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