The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
Effects of selective excitotoxic lesions of the nucleus accumbens core, anterior cingulate cortex, and central nucleus of the amygdala on autoshaping performance in rats.
Abstract
The nucleus accumbens core (AcbC), anterior cingulate cortex (ACC), and central nucleus of the amygdala (CeA) are required for normal acquisition of tasks based on stimulus-reward associations. However, it is not known whether they are involved purely in the learning process or are required for behavioral expression of a learned response. Rats were trained preoperatively on a Pavlovian autoshaping task in which pairing a visual conditioned stimulus (CS+) with food causes subjects to approach the CS+ while not approaching an unpaired stimulus (CS-). Subjects then received lesions of the AcbC, ACC, or CeA before being retested. AcbC lesions severely impaired performance; lesioned subjects approached the CS+ significantly less often than controls, failing to discriminate between the CS+ and CS-. ACC lesions also impaired performance but did not abolish discrimination entirely. CeA lesions had no effect on performance. Thus, the CeA is required for learning, but not expression, of a conditioned approach response, implying that it makes a specific contribution to the learning of stimulus-reward associations.
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“We excluded animals that did not associate the CS+ with reward.45, 46, 47 Thus, animals that failed to approach screen or reward magazine during CS+ in over 70% of trials (in the last 10 sessions before reversal) and/or failed to avoid screen or reward magazine during CS− less than 70% of trials in the same sessions, were excluded from the analysis.”
From Behavioral flexibility in a mouse model for obsessive‐compulsive disorder: Impaired Pavlovian reversal learning in SAPAP3 mutants (2019) · cites this paper as [46]
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Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex
Cardinal, R. N., Parkinson, J. A., Hall, J., & Everitt, B. J. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00007-6 · Cited by 2,129
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Self-citationThe ventral visual pathway: an expanded neural framework for the processing of object quality
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Metadata
- Authors
- Cardinal, R. N., Parkinson, J. A., Lachenal, G., Halkerston, K. M., Rudarakanchana, N., Hall, J., Morrison, C. H., Howes, S. R., Robbins, T. W., & Everitt, B. J.
- Affiliations
- University of Cambridge (GB)
- Venue
- Behavioral Neuroscience
- Published
- 2002
- Volume
- 116
- Issue
- 4
- Pages
- 553-567
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W1980915028
- Cited by
- 201
- References
- 84
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 15 · 2018: 3 · 2017: 9 · 2016: 8 · 2015: 12 · 2014: 6 · 2013: 16 · 2012: 11
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- nucleus accumbens core, anterior cingulate cortex, central amygdala, excitotoxic lesions, autoshaping, classical conditioning, stimulus-reward associations, approach behavior, discrimination learning, conditioned stimulus, reward learning
- MeSH terms
- Amygdala, Animals, Cerebral Cortex, Conditioning, Classical, Discrimination Learning, Male, Nucleus Accumbens, Rats
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