Associative learning mediates dynamic shifts in dopamine signaling in the nucleus accumbens
Abstract
The ability to predict favorable outcomes using environmental cues is an essential part of learned behavior. Dopamine neurons in the midbrain encode such stimulus-reward relationships in a manner consistent with contemporary learning models, but it is unclear how encoding this translates into actual dopamine release in target regions. Here, we sampled dopamine levels in the rat nucleus accumbens on a rapid (100 ms) timescale using electrochemical technology during a classical conditioning procedure. Early in conditioning, transient dopamine-release events signaled a primary reward, but not predictive cues. After repeated cue-reward pairings, dopamine signals shifted in time to predictive cue onset and were no longer observed at reward delivery. In the absence of stimulus-reward conditioning, there was no shift in the dopamine signal. Consistent with proposed roles in reward prediction and incentive salience, these results indicate that rapid dopamine release provides a reward signal that is dynamically modified by associative learning.
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In animal models, dopamine neurons in the midbrain exhibit burst firing in response to both primary reinforcers and conditioned stimuli once conditioning has been established.
“In animal models, dopamine neurons in the midbrain exhibit burst firing in response to both primary reinforcers and conditioned stimuli once the conditioning has been established (for example, see refs.65,66).”
From Acute social isolation evokes midbrain craving responses similar to hunger (2020) · cites this paper as [65]
The ventral striatum is implicated in Pavlovian learning.
“Considerable evidence has amassed to implicate the ventral striatum (VS) in Pavlovian learning”
From Contributions of the striatum to learning, motivation, and performance: an associative account (2012) · cites this paper as [16]
Phasic neurotransmission in the mesolimbic dopamine system is initially triggered by the receipt of reward (US), but shifts to a cue predictive of reward (CS) after associative learning.
“Phasic neurotransmission in the mesolimbic dopamine system is initially triggered by the receipt of reward (unconditional stimulus; US), but shifts to a cue predictive of reward (conditional stimulus; CS) after associative learning3,4.”
From A selective role for dopamine in stimulus-reward learning (2011) · cites this paper as [3]
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“However, it will be necessary for future studies to test this by measuring real-time DA transmission (Aragona et al., 2008; Day et al., 2007; Phillips et al., 2003) during prairie vole social interactions to determine if in vivo DA transmission is consistent with the behavioral pharmacology described in this review.”
BackgroundResultAmphetamine modulates brain signal variability and working memory in younger and older adults
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- Authors
- Day, J. J., Roitman, M. F., Wightman, R. M., & Carelli, R. M.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Carelli, Regina M
- Venue
- Nature Neuroscience
- Published
- 2007-07-01
- Volume
- 10
- Issue
- 8
- Pages
- 1020-1028
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2163773342
- Cited by
- 710
- References
- 53
- Citations by year
- 2026: 25 · 2025: 37 · 2024: 38 · 2023: 30 · 2022: 32 · 2021: 37 · 2020: 39 · 2019: 47 · 2018: 44 · 2017: 30 · 2016: 40 · 2015: 57 · 2014: 35 · 2013: 41 · 2012: 42
- FWCI
- 13.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA10900, DA 021979, K01DA018298, DA 017318, DA018298, F31DA021979, R01DA017318, R01DA010900)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- dopamine release, nucleus accumbens, associative learning, classical conditioning, reward prediction, incentive salience
- MeSH terms
- Animals, Association Learning, Behavior, Animal, Conditioning, Classical, Dopamine, Electrochemistry, Male, Nucleus Accumbens, Probability, Reward, Rats, Sprague-Dawley, Rats
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