The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
The role of hippocampal subregions in detecting spatial novelty
Abstract
Previous literature suggests that the hippocampus subserves processes associated with the encoding of novel information. To investigate the role of different subregions of the hippocampus, the authors made neurotoxic lesions in different subregions of the dorsal hippocampus (i.e., CA1, dentate gyrus [DG], or CA3) of rats, followed by tests using a spontaneous object exploration paradigm. All lesion groups explored normally an object newly introduced in a familiar location. However, when some of the familiar objects were moved to novel locations, both DG and CA3 lesion groups were severely impaired in reexploring the displaced objects, whereas the CA1 lesion group was only mildly impaired in reexploration. The results suggest that the DG-CA3 network is essential in detecting novelty for spatial, but not for individual object, information.
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“Rodents showed preference for exploring the displaced object more than the stationary ones, indicating intact spatial recognition.”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Lee et al., 2005
In the citing paper
“Also, they explored the novel object more than the familiar ones, as an indication for object recognition (Hunsaker et al., 2007a; Lee et al., 2005; Vago and Kesner, 2008).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Lee et al., 2005
Citations
Cites
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da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,015
The hippocampal-VTA loop: controlling the entry of information into long-term memory
Lisman, J. E., & Grace, A. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.002 · Cited by 1,983
Heldt, S. A., Stanek, L., Chhatwal, J. P., & Ressler, K. J. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001957 · Cited by 684
Messaoudi, E., Kanhema, T., Soule, J. D., Tiron, A., Dagytė, G., da Silva, B., & Bramham, C. R. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2883-07.2007 · Cited by 472
Assessment of spatial memory in mice
Sharma, S., Rakoczy, S. G., & Brown‐Borg, H. M. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.09.004 · Cited by 399
Metadata
- Authors
- Lee, I., Hunsaker, M. R., & Kesner, R. P.
- Affiliations
- Boston University (US)
- University of Utah (US)
- Venue
- Behavioral Neuroscience
- Published
- 2005
- Volume
- 119
- Issue
- 1
- Pages
- 145-153
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2154243350
- Cited by
- 270
- References
- 51
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 10 · 2023: 5 · 2022: 8 · 2021: 11 · 2020: 7 · 2019: 8 · 2018: 13 · 2017: 14 · 2016: 14 · 2015: 15 · 2014: 17 · 2013: 17 · 2012: 19
- FWCI
- 8.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampal subfields, dorsal hippocampus, dentate gyrus, CA1, CA3, neurotoxic lesion, spatial memory, novel object recognition
- MeSH terms
- Animals, Cognition, Exploratory Behavior, Hippocampus, Male, Space Perception, Rats, Long-Evans, Rats
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