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The role of hippocampal subregions in detecting spatial novelty

Lee, Inah, Hunsaker, Michael R., Kesner, Raymond P.·2005·Behavioral Neuroscience

DOI 10.1037/0735-7044.119.1.145

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Abstract

Previous literature suggests that the hippocampus subserves processes associated with the encoding of novel information. To investigate the role of different subregions of the hippocampus, the authors made neurotoxic lesions in different subregions of the dorsal hippocampus (i.e., CA1, dentate gyrus [DG], or CA3) of rats, followed by tests using a spontaneous object exploration paradigm. All lesion groups explored normally an object newly introduced in a familiar location. However, when some of the familiar objects were moved to novel locations, both DG and CA3 lesion groups were severely impaired in reexploring the displaced objects, whereas the CA1 lesion group was only mildly impaired in reexploration. The results suggest that the DG-CA3 network is essential in detecting novelty for spatial, but not for individual object, information.

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Authors: Lee, I., Hunsaker, M. R., & Kesner, R. P.
Affiliations: Boston University (US)
University of Utah (US)
ORCID: Lee, Inah
Hunsaker, Michael R.
Venue: Behavioral Neuroscience
Publisher: American Psychological Association (APA)
Published: 2005
Volume: 119
Issue: 1
Pages: 145-153
ISSN: 0735-7044 (ISSN-L)
1939-0084
DOI: 10.1037/0735-7044.119.1.145
OpenAlex: W2154243350
Cited by: 270
References: 51
Citations by year: 2026: 3 · 2025: 3 · 2024: 10 · 2023: 5 · 2022: 8 · 2021: 11 · 2020: 7 · 2019: 8 · 2018: 13 · 2017: 14 · 2016: 14 · 2015: 15 · 2014: 17 · 2013: 17 · 2012: 19
FWCI: 8.57
Type: journal article
Language: en
Open access: closed
Locations: Behavioral Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: hippocampal subfields, dorsal hippocampus, dentate gyrus, CA1, CA3, neurotoxic lesion, spatial memory, novel object recognition
MeSH terms: Animals, Cognition, Exploratory Behavior, Hippocampus, Male, Space Perception, Rats, Long-Evans, Rats

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The role of hippocampal subregions in detecting spatial novelty

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