Advancing the spontaneous hypertensive rat model of attention deficit/hyperactivity disorder.
Abstract
To advance the spontaneous hypertensive rat (SHR) model of attention deficit/hyperactivity disorder (ADHD), experiments examined the SHR in tasks recognized to assess functioning of the prefrontal cortex or dorsal striatal. Tasks included odor-delayed win-shift (nonspatial working and reference memory), win-stay (habit learning), and attentional set-shifting (attention and behavioral flexibility). In Experiment 1, the SHR strain was compared with Wistar-Kyoto (WKY) and Wistar-Kyoto Hypertensive (WKHT) strains on the first 2 tasks. In Experiment 2, oral methylphenidate (1.5 mg/kg) and vehicle (water) were evaluated on all 3 tasks in SHR and WKY strains. Results demonstrated that the SHR made significantly more errors in the odor-delayed win-shift, win-stay, and attentional set-shifting tasks compared with the WKY. Similar performances in the WKY and WKHT indicated that deficits observed in the SHR were not related solely to hypertension. Treating the SHR with methylphenidate eliminated strain differences in all 3 tasks. These findings provide evidence that the SHR is a valid model for studying ADHD-associated neurocognitive deficits. Moreover, the current behavioral approach is appropriate to assess novel medications developed to target ADHD-associated neurocognitive deficits.
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Maze performance of SHR rats suggests they preferentially use response strategies to guide behavior in spatial tasks.
“Maze performance of SHR rats suggests they preferentially use response strategies to guide behavior in spatial tasks (Clements and Wainwright, 2006; Clements et al., 2007; Kantak et al., 2008).”
From The Effects of Methylphenidate on Goal-directed Behavior in a Rat Model of ADHD (2015) · cites this paper as Kantak et al., 2008
MPH corrects attentional and motor impairments in SHR rats.
“Likewise, MPH corrects attentional and motor impairments in SHR rats, lending further support for SHR rats as a model of human ADHD (Sagvolden et al., 2005a,b; Kantak et al., 2008).”
From The Effects of Methylphenidate on Goal-directed Behavior in a Rat Model of ADHD (2015) · cites this paper as Kantak et al., 2008
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“demands were relatively difficult, but not when they were easy, which is an outcome consistent with the clinical literature showing that working memory deficits become more apparent in individuals with ADHD when task demands increase (Martinussen et al., 2005).”
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The neuropharmacology of ADHD drugs in vivo: Insights on efficacy and safety
Heal, D. J., Cheetham, S. C., & Smith, S. L. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.08.020 · Cited by 198 · see citing works
Harvey, R. C., Sen, S., Deaciuc, A., Dwoskin, L. P., & Kantak, K. M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.223 · Cited by 86 · see citing works
Self-citationJordan, C. J., Harvey, R. C., Baskin, B. B., Dwoskin, L. P., & Kantak, K. M. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.04.020 · Cited by 38 · see citing works
Self-citationSomkuwar, S. S., Darna, M., Kantak, K. M., & Dwoskin, L. P. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.04.013 · Cited by 37 · see citing works
Self-citationThe Effects of Methylphenidate on Goal-directed Behavior in a Rat Model of ADHD
Natsheh, J. Y., & Shiflett, M. W. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00326 · Cited by 21 · see citing works
Baskin, B. M., Dwoskin, L. P., & Kantak, K. M. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.01.019 · Cited by 20 · see citing works
Self-citation
- Authors
- Kantak, K. M., Singh, T., Kerstetter, K. A., Dembro, K. A., Mutebi, M. M., Harvey, R. C., Deschepper, C. F., & Dwoskin, L. P.
- Affiliations
- Boston University (US)
- Montreal Clinical Research Institute (CA)
- University of Kentucky (US)
- Venue
- Behavioral Neuroscience
- Published
- 2008
- Volume
- 122
- Issue
- 2
- Pages
- 340-357
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2032906358
- Cited by
- 95
- References
- 9
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 8 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 2 · 2015: 12 · 2014: 5 · 2013: 5 · 2012: 8
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (SBE-0354378)
- National Institute on Drug Abuse (RO1 DA 11716)
- Center for Drug Abuse Research Translation (P50 DA05312)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- attention deficit hyperactivity disorder, spontaneously hypertensive rats, animal model of ADHD, methylphenidate, set-shifting, working memory, reference memory, habit learning, prefrontal cortex, dorsal striatum, neurocognitive impairment, hypertension, Wistar-Kyoto rats
- MeSH terms
- Central Nervous System Stimulants, Animals, Association Learning, Attention, Attention Deficit Disorder with Hyperactivity, Discrimination Learning, Disease Models, Animal, Impulsive Behavior, Memory, Short-Term, Methylphenidate, Rats, Inbred SHR, Rats, Inbred WKY, Rats, Mutant Strains, Set, Psychology, Neostriatum, Prefrontal Cortex, Rats
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