Adolescence methylphenidate treatment in a rodent model of attention deficit/hyperactivity disorder: dopamine transporter function and cellular distribution in adulthood

Somkuwar, Sucharita S.; Darna, Mahesh; Kantak, Kathleen M.; Dwoskin, Linda P.

doi:10.1016/j.bcp.2013.04.013

Cited by 37Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Adolescence methylphenidate treatment in a rodent model of attention deficit/hyperactivity disorder: dopamine transporter function and cellular distribution in adulthood

Open access

Somkuwar, Sucharita S., Darna, Mahesh, Kantak, Kathleen M., Dwoskin, Linda P.·2013·Biochemical Pharmacology

DOI 10.1016/j.bcp.2013.04.013PMC PMC3709249

Open this paper in CoChat — free account

Abstract

Attention deficit/hyperactivity disorder (ADHD) is attributed to dysfunction of the prefrontal cortex. Methylphenidate, an inhibitor of dopamine and norepinephrine transporters (DAT and NET, respectively), is a standard treatment for ADHD. The Spontaneously Hypertensive Rat (SHR) is a well-established animal model of ADHD. Our previous results showed that methylphenidate treatment in adolescent SHR enhanced cocaine self-administration during adulthood, and alterations in DAT function in prefrontal cortex play a role in this response. Importantly, prefrontal cortex subregions, orbitofrontal cortex (OFC) and medial prefrontal cortex (mPFC), have been shown to have distinct roles in ADHD and cocaine self-administration. In the current study, SHR, Wistar-Kyoto (WKY) and Wistar (WIS) rats received a therapeutically relevant dose of methylphenidate (1.5mg/kg, p.o.) or vehicle during adolescence and then OFC and mPFC DAT function and cellular expression were assessed during adulthood. In both OFC and mPFC, no strain differences in Vmax or Km for dopamine uptake into synaptosomes were found between vehicle-treated SHR, WKY and WIS. Methylphenidate increased DAT Vmax in SHR mPFC and decreased DAT Vmax in WKY OFC. Also, methylphenidate decreased DAT Km in WIS OFC. Further, methylphenidate did not alter DAT cellular localization, indicating that methylphenidate treatment during adolescence regulated DAT function in SHR mPFC in a trafficking-independent manner. Thus, the increase in mPFC DAT function was an SHR-specific long term consequence of methylphenidate treatment during adolescence, which may be responsible for the treatment-induced alterations in behavior including the observed increases in cocaine self-administration.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.bcp.2013.04.013

Cites

83 of 83 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works
Linear Mixed Models for Longitudinal Data
Verbeke, G. (1997) · Lecture Notes in Statistics · doi:10.1007/978-1-4612-2294-1_3 · Cited by 3,506 · see citing works
Linear Mixed Models for Longitudinal Data
Molenberghs, G., & Verbeke, G. N. (2000) · Springer series in statistics · doi:10.1007/978-1-4419-0300-6 · Cited by 2,681 · see citing works
Molecular genetics of attention-deficit/hyperactivity disorder
Faraone, S. V., Perlis, R. H., Doyle, A. E., Smoller, J. W., Goralnick, J. J., Holmgren, M. A., & Sklar, P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.024 · Cited by 2,357 · see citing works
a dynamic developmental theory of attention-deficit/hyperactivity disorder (adhd) predominantly hyperactive/impulsive and combined subtypes
sagvolden, T., johansen, E. B., aase, H., & russell, V. A. (2005) · Behavioral and Brain Sciences · doi:10.1017/s0140525x05000075 · Cited by 1,035 · see citing works
Do rats have a prefrontal cortex?
Uylings, H. B. M., Groenewegen, H. J., & Kolb, B. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.09.028 · Cited by 1,013 · see citing works
Causal Models of Attention-Deficit/Hyperactivity Disorder: From Common Simple Deficits to Multiple Developmental Pathways
Sonuga-Barke, E. J. S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.09.008 · Cited by 962 · see citing works
Does stimulant therapy of attention-deficit/hyperactivity disorder beget later substance abuse? A meta-analytic review of the literature
Wilens, T. E., Faraone, S. V., Biederman, J., & Gunawardene, S. (2003) · Pediatrics · doi:10.1542/peds.111.1.179 · Cited by 872 · see citing works
Methylphenidate Preferentially Increases Catecholamine Neurotransmission within the Prefrontal Cortex at Low Doses that Enhance Cognitive Function
Berridge, C. W., Devilbiss, D. M., Andrzejewski, M. E., Arnsten, A. F. T., Kelley, A. E., Schmeichel, B., Hamilton, C., & Spencer, R. C. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.022 · Cited by 617 · see citing works
Cingulate Hypoactivity in Cocaine Users During a GO-NOGO Task as Revealed by Event-Related Functional Magnetic Resonance Imaging
Kaufman, J. N., Ross, T. J., Stein, E. A., & Garavan, H. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-21-07839.2003 · Cited by 553 · see citing works
Blockade by antidepressants and related compounds of biogenic amine uptake into rat brain synaptosomes: Most antidepressants selectively block norepinephrine uptake
Richelson, E., & Pfenning, M. A. (1984) · European Journal of Pharmacology · doi:10.1016/0014-2999(84)90403-5 · Cited by 529 · see citing works
Neurobiology of ADHD
Tripp, G., & Wickens, J. R. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.07.026 · Cited by 492 · see citing works
Prospective Study of Tobacco Smoking and Substance Dependencies Among Samples of ADHD and Non-ADHD Participants
Lambert, N. M., & Hartsough, C. S. (1998) · Journal of Learning Disabilities · doi:10.1177/002221949803100603 · Cited by 465 · see citing works
Executive function
Gilbert, S. J., & Burgess, P. W. (2008) · Current Biology · doi:10.1016/j.cub.2007.12.014 · Cited by 455 · see citing works
Rodent Models of Attention-Deficit/Hyperactivity Disorder
Sagvolden, T., Russell, V. A., Aase, H., Johansen, E. B., & Farshbaf, M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.02.002 · Cited by 448 · see citing works
Functional Magnetic Resonance Imaging of Human Brain Activation During Cue-Induced Cocaine Craving
Maas, L. C., Lukas, S. E., Kaufman, M. J., Weiss, R. D., Daniels, S. L., Rogers, V. W., Kukes, T. J., & Renshaw, P. F. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.1.124 · Cited by 434 · see citing works
Molecular Genetics of Attention Deficit Hyperactivity Disorder
Faraone, S. V., & Mick, E. (2010) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2009.12.004 · Cited by 411 · cited 2× · see citing works
“Further, ADHD is associated with increased dopamine transporter (DAT) expression in striatum and with specific polymorphisms in the DAT gene [5, 6].”
Background
Motivational systems in adolescence: Possible implications for age differences in substance abuse and other risk-taking behaviors
Doremus-Fitzwater, T. L., Varlinskaya, E. I., & Spear, L. P. (2010) · Brain and Cognition · doi:10.1016/j.bandc.2009.08.008 · Cited by 397 · see citing works
Toward a New Understanding of Attention-Deficit Hyperactivity Disorder Pathophysiology: An Important Role for Prefrontal Cortex Dysfunction
Arnsten, A. F. T. (2009) · CNS Drugs · doi:10.2165/00023210-200923000-00005 · Cited by 371 · see citing works
Imaging the effects of methylphenidate on brain dopamine: new model on its therapeutic actions for attention-deficit/hyperactivity disorder
Volkow, N. D., Wang, G.-J., Fowler, J. S., & Ding, Y.-S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.006 · Cited by 368 · see citing works
The dopamine uptake inhibitor GBR 12909: selectivity and molecular mechanism of action
Andersen, P. H. (1989) · European Journal of Pharmacology · doi:10.1016/0014-2999(89)90363-4 · Cited by 347 · see citing works
Expression of the dopamine transporter gene is regulated by the 3′ UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR
Mill, J., Asherson, P., Browes, C., D'Souza, U., & Craig, I. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.b.10948 · Cited by 341 · see citing works
Exposure of adolescent rats to oral methylphenidate: preferential effects on extracellular norepinephrine and absence of sensitization and cross-sensitization to methamphetamine
Kuczenski, R., & Segal, D. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07264.2002 · Cited by 316 · see citing works
Impulsiveness as a timing disturbance: neurocognitive abnormalities in attention-deficit hyperactivity disorder during temporal processes and normalization with methylphenidate
Rubia, K., Halari, R., Christakou, A., & Taylor, E. (2009) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2009.0014 · Cited by 310 · see citing works
Does the Treatment of Attention-Deficit/Hyperactivity Disorder With Stimulants Contribute to Drug Use/Abuse? A 13-Year Prospective Study
Barkley, R. A., Fischer, M., Smallish, L., & Fletcher, K. (2003) · Pediatrics · doi:10.1542/peds.111.1.97 · Cited by 274 · see citing works
Age of methylphenidate treatment initiation in children with ADHD and later substance abuse: prospective follow-up into adulthood.
Mannuzza, S., Klein, R. G., Truong, N. L., Moulton, J. L., Roizen, E. R., Howell, K. H., & Castellanos, F. X. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07091465 · Cited by 263 · see citing works
Striatal dopamine transporter alterations in ADHD: pathophysiology or adaptation to psychostimulants? A meta-analysis
Fusar-Poli, P., Rubia, K., Rossi, G., Sartori, G., & Balottin, U. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11060940 · Cited by 260 · see citing works
Modeling adolescent development and alcohol use in animals.
SPEAR, L. P. (2000) · PubMed Central · Cited by 258 · see citing works
Brain dopamine transporter levels in treatment and drug naive adults with ADHD
Volkow, N. D., Wang, G.-J., Newcorn, J., Fowler, J. S., Telang, F., Solanto, M. V., Logan, J., Wong, C., Ma, Y., Swanson, J. M., et al. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.10.014 · Cited by 249 · see citing works
Distinct Roles of Prefrontal Cortical Subregions in the Iowa Gambling Task
Lawrence, N., Jollant, F., O’Daly, O., Zelaya, F. O., & Phillips, M. L. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn154 · Cited by 231 · see citing works
Insight Into the Relationship Between Impulsivity and Substance Abuse From Studies Using Animal Models
Winstanley, C. A., Olausson, P., Taylor, J. R., & Jentsch, J. D. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01215.x · Cited by 229 · see citing works
Pretreatment Brain Activation During Stroop Task Is Associated with Outcomes in Cocaine-Dependent Patients
Brewer, J. A., Worhunsky, P. D., Carroll, K. M., Rounsaville, B. J., & Potenza, M. N. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.024 · Cited by 226 · see citing works
Cocaine Increases Dopamine Uptake and Cell Surface Expression of Dopamine Transporters
Daws, L. C., Callaghan, P. D., Morón, J. A., Kahlig, K. M., Shippenberg, T. S., Javitch, J. A., & Galli, A. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6384 · Cited by 208 · see citing works
The spontaneously hypertensive rat model of ADHD – The importance of selecting the appropriate reference strain
Sagvolden, T., Johansen, E. B., Wøien, G., Walaas, S. I., Storm‐Mathisen, J., Bergersen, L. H., Hvalby, Ø., Jensen, V., Aase, H., Russell, V. A., et al. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.08.004 · Cited by 206 · see citing works
Altered dopaminergic function in the prefrontal cortex, nucleus accumbens and caudate-putamen of an animal model of attention-deficit hyperactivity disorder–the spontaneously hypertensive rat.
Russell, V., de Villiers, A., Sagvolden, T., Lamm, M., & Taljaard, J. (1995) · Brain Research · doi:10.1016/0006-8993(95)00135-d · Cited by 200 · see citing works
Does ADHD Affect the Course of Substance Abuse? Findings From a Sample of Adults With and Without ADHD
Wilens, T. E., Biederman, J., & Mick, E. O. (1998) · American Journal on Addictions · doi:10.1111/j.1521-0391.1998.tb00330.x · Cited by 196 · see citing works
Activation of Protein Kinase C Inhibits Uptake, Currents and Binding Associated with the Human Dopamine Transporter Expressed in Xenopus Oocytes
Zhu, S.-J., Kavanaugh, M. P., Sonders, M. S., Amara, S. G., & Zahniser, N. R. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36962-9 · Cited by 182 · see citing works
Prefrontal cortex and drug abuse vulnerability: Translation to prevention and treatment interventions
Perry, J. L., Joseph, J. E., Jiang, Y., Zimmerman, R. S., Kelly, T. H., Darna, M., Huettl, P., Dwoskin, L. P., & Bardo, M. T. (2011) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.09.001 · Cited by 180 · see citing works
Self-citation
Poor response inhibition: At the nexus between substance abuse and attention deficit/hyperactivity disorder
Groman, S. M., James, A. S., & Jentsch, J. D. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.08.008 · Cited by 176 · see citing works
Constitutive and Protein Kinase C‐Induced Internalization of the Dopamine Transporter is Mediated by a Clathrin‐Dependent Mechanism
Sorkina, T., Hoover, B. R., Zahniser, N. R., & Sorkin, A. D. (2004) · Traffic · doi:10.1111/j.1600-0854.2005.00259.x · Cited by 172 · see citing works
Spontaneously hypertensive rats do not predict symptoms of attention-deficit hyperactivity disorder
van den Bergh, F. S., Bloemarts, E., Chan, J. S. W., Groenink, L., Olivier, B., & Oosting, R. S. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.02.018 · Cited by 164 · see citing works
Addiction changes orbitofrontal gyrus function: involvement in response inhibition
Goldstein, R. Z., Volkow, N. D., Wang, G., Fowler, J. S., & Rajaram, S. (2001) · Neuroreport · doi:10.1097/00001756-200108080-00060 · Cited by 160 · see citing works
Attentional Control Activation Relates to Working Memory in Attention-Deficit/Hyperactivity Disorder
Burgess, G. C., Depue, B. E., Ruzic, L., Willcutt, E. G., Du, Y. P., & Banich, M. T. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.10.036 · Cited by 147 · see citing works
Dopaminergic and Noradrenergic Contributions to Functionality in ADHD: The Role of Methylphenidate
Engert, V., & Pruessner, J. (2008) · Current Neuropharmacology · doi:10.2174/157015908787386069 · Cited by 146 · see citing works
Membrane Mobility and Microdomain Association of the Dopamine Transporter Studied with Fluorescence Correlation Spectroscopy and Fluorescence Recovery after Photobleaching
Adkins, E. M., Samuvel, D. J., Fog, J. U., Eriksen, J., Jayanthi, L. D., Vægter, C. B., Ramamoorthy, S., & Gether, U. (2007) · Biochemistry · doi:10.1021/bi700429z · Cited by 145 · see citing works
Phorbol ester induced trafficking‐independent regulation and enhanced phosphorylation of the dopamine transporter associated with membrane rafts and cholesterol
Foster, J. D., Adkins, S. D., Lever, J., & Vaughan, R. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05262.x · Cited by 144 · see citing works
Supersensitivity to the reinforcing effects of cocaine following 6-hydroxydopamine lesions to the medial prefrontal cortex in rats
Schenk, S., Horger, B. A., Peltier, R., & Shelton, K. L. (1991) · Brain Research · doi:10.1016/0006-8993(91)90032-q · Cited by 140 · see citing works
A distinct neurochemical profile in WKY rats at baseline and in response to acute stress: implications for animal models of anxiety and depression
Garza, R. D. L., & Mahoney, J. J. (2004) · Brain Research · doi:10.1016/j.brainres.2004.06.052 · Cited by 131 · see citing works
Environmental enrichment decreases cell surface expression of the dopamine transporter in rat medial prefrontal cortex
Zhu, J., Apparsundaram, S., Bardo, M. T., & Dwoskin, L. P. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03130.x · Cited by 130 · see citing works
Self-citation
Caffeine Regulates Frontocorticostriatal Dopamine Transporter Density and Improves Attention and Cognitive Deficits in an Animal Model of Attention Deficit Hyperactivity Disorder
Pandolfo, P., Machado, N. J., Köfalvi, A., Takahashi, R. N., & Cunha, R. A. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.04.011 · Cited by 118 · see citing works
Context-dependent prefrontal cortex regulation of cocaine self-administration and reinstatement behaviors in rats
Di Pietro, N. C., Black, Y. D., & Kantak, K. M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05193.x · Cited by 107 · see citing works
Self-citation
New perspectives from microdialysis studies in freely-moving, spontaneously hypertensive rats on the pharmacology of drugs for the treatment of ADHD.
Heal, D. J., Smith, S. L., Kulkarni, R. S., & Rowley, H. L. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.03.016 · Cited by 105 · see citing works
The attenuation of dysfunctional emotional processing with stimulant medication: An fMRI study of adolescents with ADHD
Posner, J., Maia, T. V., Fair, D., Peterson, B. S., Sonuga-Barke, E. J., & Nagel, B. J. (2011) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2011.02.005 · Cited by 104 · see citing works
Advancing the spontaneous hypertensive rat model of attention deficit/hyperactivity disorder.
Kantak, K. M., Singh, T., Kerstetter, K. A., Dembro, K. A., Mutebi, M. M., Harvey, R. C., Deschepper, C. F., & Dwoskin, L. P. (2008) · Behavioral Neuroscience · doi:10.1037/0735-7044.122.2.340 · Cited by 95 · see citing works
Self-citation
Mechanism for Cocaine Blocking the Transport of Dopamine: Insights from Molecular Modeling and Dynamics Simulations
Huang, X., Gu, H. H., & Zhan, C. (2009) · The Journal of Physical Chemistry B · doi:10.1021/jp900963n · Cited by 93 · see citing works
Effect of 6-hydroxydopamine lesions of the medial prefrontal cortex on intravenous cocaine self-administration under a progressive ratio schedule of reinforcement
McGregor, A. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)00192-1 · Cited by 87 · see citing works
The usefulness of the spontaneously hypertensive rat to model attention-deficit/hyperactivity disorder (ADHD) may be explained by the differential expression of dopamine-related genes in the brain
LI, Q., Lü, G., Antonio, G. E., Mak, Y. F., Rudd, J. A., Fan, M., & Yew, D. T. W. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.02.005 · Cited by 86 · see citing works
Methylphenidate treatment in adolescent rats with an attention deficit/hyperactivity disorder phenotype: cocaine addiction vulnerability and dopamine transporter function
Harvey, R. C., Sen, S., Deaciuc, A., Dwoskin, L. P., & Kantak, K. M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.223 · Cited by 86 · see citing works
Self-citation
Trafficking of dopamine transporters in psychostimulant actions
Zahniser, N. R., & Sorkin, A. D. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.01.004 · Cited by 86 · see citing works
Parallel studies of cocaine-related neural and cognitive impairment in humans and monkeys
Beveridge, T. J. R., Gill, K. E., Hanlon, C. A., & Porrino, L. J. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0102 · Cited by 86 · see citing works
Strain differences in the distribution of dopamine transporter sites in rat brain
Jiao, X., Paré, W. P., & Tejani‐Butt, S. M. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00150-7 · Cited by 84 · see citing works
Dopamine vs Noradrenaline: Inverted-U Effects and ADHD Theories
Lévy, F. (2009) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670802607238 · Cited by 77 · see citing works
Methylphenidate normalizes elevated dopamine transporter densities in an animal model of the attention-deficit/hyperactivity disorder combined type, but not to the same extent in one of the attention-deficit/hyperactivity disorder inattentive type
Roessner, V., Sagvolden, T., DasBanerjee, T., Middleton, F. A., Faraone, S. V., Walaas, S. I., Becker, A., Rothenberger, A., & Bock, N. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.02.073 · Cited by 76 · see citing works
Decreased plasma membrane expression of striatal dopamine transporter in aging
Salvatore, M. F. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00129-5 · Cited by 72 · see citing works
Problems with spontaneously hypertensive rats (SHR) as a model of attention-deficit/hyperactivity disorder (AD/HD)
Alsop, B. (2006) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2006.12.002 · Cited by 70 · see citing works
The spontaneously hypertensive and Wistar Kyoto rat models of ADHD exhibit sub-regional differences in dopamine release and uptake in the striatum and nucleus accumbens
Miller, E. M., Pomerleau, F., Huettl, P. F., Russell, V. A., Gerhardt, G. A., & Glaser, P. E. A. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.08.020 · Cited by 62 · see citing works
Phosphorylation of Dopamine Transporter Serine 7 Modulates Cocaine Analog Binding*
Moritz, A. E., Foster, J., Gorentla, B. K., Mazei-Robison, M., Yang, J.-W., Sitte, H., Blakely, R., & Vaughan, R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.407874 · Cited by 55 · see citing works
Interaction of the rostral basolateral amygdala and prelimbic prefrontal cortex in regulating reinstatement of cocaine-seeking behavior
Mashhoon, Y., Wells, A. M., & Kantak, K. M. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.06.005 · Cited by 52 · see citing works
Self-citation
Childhood stimulant treatment and risk for later substance abuse.
Fischer, M., & Barkley, R. A. (2003) · PubMed · Cited by 48 · see citing works
Medication for Children With Attentional Disorders
Committee on Children, & Disabilities and Committee on Drugs (1996) · PEDIATRICS · doi:10.1542/peds.98.2.301 · Cited by 44 · see citing works
Strain differences in the distribution of dopamine (DA-2 and DA-3) receptor sites in rat brain
Yaroslavsky, I., Colletti, M., Jiao, X., & Tejani‐Butt, S. M. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.02.030 · Cited by 43 · see citing works
Alcohol & Drug Abuse: Practical Guidelines for the Treatment of Substance Abusers With Adult Attention-Deficit Hyperactivity Disorder
LEVIN, F. R., Evans, S. M., & Kleber, H. D. (1999) · Psychiatric Services · doi:10.1176/ps.50.8.1001 · Cited by 43 · see citing works
A multivariate assessment of individual differences in sensation seeking and impulsivity as predictors of amphetamine self-administration and prefrontal dopamine function in rats.
Marusich, J. A., Darna, M., Charnigo, R. J., Dwoskin, L. P., & Bardo, M. T. (2011) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0023897 · Cited by 40 · see citing works
Self-citation
Strain differences in the expression of dopamine D1 receptors in Wistar–Kyoto (WKY) and Wistar rats
Novick, A. M., Yaroslavsky, I., & Tejani‐Butt, S. M. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.05.006 · Cited by 39 · see citing works
Dysregulation of Dopamine Transporter Trafficking and Function after Abstinence from Cocaine Self-Administration in Rats: Evidence for Differential Regulation in Caudate Putamen and Nucleus Accumbens
Samuvel, D. J., Jayanthi, L. D., Manohar, S., Kaliyaperumal, K., See, R. E., & Ramamoorthy, S. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.130534 · Cited by 36 · see citing works
Maternal separation affects dopamine transporter function in the Spontaneously Hypertensive Rat: An in vivo electrochemical study
Womersley, J. S., Hsieh, J. H., Kellaway, L. A., Gerhardt, G. A., & Russell, V. A. (2011) · Behavioral and Brain Functions · doi:10.1186/1744-9081-7-49 · Cited by 34 · see citing works
Performance on a strategy set shifting task during adolescence in a genetic model of attention deficit/hyperactivity disorder: Methylphenidate vs. atomoxetine treatments
Harvey, R. C., Jordan, C. J., Tassin, D. H., Moody, K. R., Dwoskin, L. P., & Kantak, K. M. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.01.027 · Cited by 33 · see citing works
Self-citation
A Prospective Examination of the Association of Stimulant Medication History and Drug Use Outcomes among Community Samples of ADHD Youths
Winters, K. C., Lee, S., Botzet, A., Fahnhorst, T., Realmuto, G. M., & August, G. J. (2011) · Journal of Child & Adolescent Substance Abuse · doi:10.1080/1067828x.2011.598834 · Cited by 22 · see citing works
Low and high cocaine locomotor responding male Sprague–Dawley rats differ in rapid cocaine-induced regulation of striatal dopamine transporter function
Mandt, B. H., & Zahniser, N. R. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.11.015 · Cited by 21 · see citing works
Altered dopamine transporter function and phosphorylation following chronic cocaine self-administration and extinction in rats
Ramamoorthy, S., Samuvel, D. J., Annamalai, B., See, R. E., & Jayanthi, L. D. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.12.110 · Cited by 19 · see citing works
Effects of orbitofrontal cortex lesions on cocaine self-administration
Grakalic, I., Panlilio, L. V., Quiroz, C., & Schindler, C. W. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.10.051 · Cited by 18 · see citing works
Impact of medial orbital cortex and medial subthalamic nucleus inactivation, individually and together, on the maintenance of cocaine self-administration behavior in rats
Kantak, K. M., Yager, L. M., & Brisotti, M. F. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.10.021 · Cited by 16 · see citing works
Self-citation
Medication for children with attentional disorders. American Academy of Pediatrics Committee on Children With Disabilities and Committee on Drugs.
(1996) · PubMed · Cited by 9 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

[55]Vadum AC Rankin NO Psychological research: methods for discovery and validation 1998 Boston, Mass McGraw-Hill

Sorted by citations

The pharmacology of amphetamine and methylphenidate: Relevance to the neurobiology of attention-deficit/hyperactivity disorder and other psychiatric comorbidities
Faraone, S. V. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.02.001 · Cited by 631 · see citing works
Trends in use of prescription stimulants in the United States and Territories, 2006 to 2016
Piper, B. J., Ogden, C. L., Simoyan, O. M., Chung, D. Y., Caggiano, J. F., Nichols, S. D., & McCall, K. L. (2018) · PLOS ONE · doi:10.1371/journal.pone.0206100 · Cited by 170 · see citing works
Cocaine-seeking behavior in a genetic model of attention-deficit/hyperactivity disorder following adolescent methylphenidate or atomoxetine treatments
Jordan, C. J., Harvey, R. C., Baskin, B. B., Dwoskin, L. P., & Kantak, K. M. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.04.020 · Cited by 38 · see citing works
Self-citation
Methylphenidate treatment beyond adolescence maintains increased cocaine self-administration in the spontaneously hypertensive rat model of attention deficit/hyperactivity disorder
Baskin, B. M., Dwoskin, L. P., & Kantak, K. M. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.01.019 · Cited by 20 · see citing works
Self-citation

Novel Benztropine [3a-(Diphenylmethoxy)tropane] Analogs as Probes for the Dopamine Transporter
Newman, A. H., & Agoston, G. E. (1998) · Current Medicinal Chemistry · doi:10.2174/0929867305666220314215936 · Cited by 27 · see citing works
Differential Binding of Tropane-Based Photoaffinity Ligands on the Dopamine Transporter
Vaughan, R. A., Agoston, G. E., Lever, J. R., et al. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-02-00630.1999 · Cited by 72 · see citing works
The binding sites for cocaine and dopamine in the dopamine transporter overlap
Beuming, T., Kniazeff, J., Bergmann, M. L., Shi, L., Gracia, L., Raniszewska, K., Newman, A. H., Javitch, J. A., Weinstein, H., Gether, U., et al. (2008) · Nature Neuroscience · doi:10.1038/nn.2146 · Cited by 354 · see citing works
Fluctuation of the dopamine uptake inhibition potency of cocaine, but not amphetamine, at mammalian cells expressing the dopamine transporter
Ukairo, O. T., Ramanujapuram, S., & Surratt, C. K. (2006) · Brain Research · doi:10.1016/j.brainres.2006.11.018 · Cited by 12 · see citing works
Release of dopamine via the human transporter.
Eshleman, A., Henningsen, R. A., Neve, K., & Janowsky, A. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09929-8 · Cited by 168 · see citing works

Authors: Somkuwar, S. S., Darna, M., Kantak, K. M., & Dwoskin, L. P.
Affiliations: University of Kentucky (US)
Boston University (US)
Corresponding author: Dwoskin, Linda P.
ORCID: Somkuwar, Sucharita S.
Kantak, Kathleen M.
Venue: Biochemical Pharmacology
Publisher: Elsevier BV
Published: 2013-07
Volume: 86
Issue: 2
Pages: 309-316
ISSN: 0006-2952 (ISSN-L)
DOI: 10.1016/j.bcp.2013.04.013
PMC: PMC3709249
OpenAlex: W2077398583
Cited by: 37
References: 83
Citations by year: 2026: 1 · 2025: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2019: 1 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 11 · 2014: 4 · 2013: 1
FWCI: 4.50
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Biochemical Pharmacology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Drug Abuse (R01DA011716)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: attention deficit hyperactivity disorder, methylphenidate, dopamine transporter, spontaneously hypertensive rats, adolescent treatment, prefrontal cortex, medial prefrontal cortex, orbitofrontal cortex, dopamine uptake, cocaine self-administration, transporter trafficking, strain differences
MeSH terms: Central Nervous System Stimulants, Animals, Attention Deficit Disorder with Hyperactivity, Disease Models, Animal, Male, Methylphenidate, Rats, Inbred SHR, Rats, Inbred WKY, Dopamine Plasma Membrane Transport Proteins, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Adolescence methylphenidate treatment in a rodent model of attention deficit/hyperactivity disorder: dopamine transporter function and cellular distribution in adulthood

Abstract

Integrity signals

Claims the paper makes

Self-check

Cites

Cited by

Related

Record

About these checks