The Effects of Dopamine D1Receptor Blockade in the Prelimbic–Infralimbic Areas on Behavioral Flexibility
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This study examined the effects of a dopamine D 1 antagonist, SCH23390, infused into the prelimbic–infralimbic areas on the acquisition of a response and visual-cue discrimination task, as well as a shift from a response to a visual-cue discrimination and vice versa. Each test was carried out in a cross-maze. The response discrimination required learning to always turn in the same direction (right or left) for a cereal reinforcement. The visual-cue discrimination required learning to always enter the arm with the visual cue. In experiment 1, rats were tested on the response discrimination task, followed by the visual-cue discrimination task. In experiment 2, the testing order was reversed. Bilateral infusions of SCH23390 (0.1 or 1 μg/0.5 μL) into the prelimbic–infralimbic areas did not impair acquisition of the response or visual-cue discrimination tasks. SCH23390 injections at 1 μg, but not 0.1 μg impaired performance when shifting from a response to a visual-cue discrimination, and vice versa. Analysis of the errors revealed that the deficit was due to perseveration of the previously learned strategy. These results suggest that activation of dopamine D 1 receptors in the prelimbic–infralimbic areas may be critical for the suppression of a previously relevant strategy and/or generating new strategies.
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The D1 receptor antagonist SCH23390 infused within the mPFC impairs set-shifting in rats.
“the D1 receptor antagonist SCH23390 infused within the mPFC impaired set-shifting in rats (Haluk & Floresco 2009, Ragozzino 2002)”
From Prefrontal cortex executive processes affected by stress in health and disease (2018) · cites this paper as Ragozzino 2002
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- Authors
- Ragozzino, M. E.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Ragozzino, Michael E.
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2002-01-01
- Volume
- 9
- Issue
- 1
- Pages
- 18-28
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- PMC
- PMC155930
- OpenAlex
- W2105133778
- Cited by
- 174
- References
- 57
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 8 · 2017: 6 · 2016: 11 · 2015: 14 · 2014: 13 · 2013: 9 · 2012: 7
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Learning & Memory (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R03MH061889, MH61889)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- dopamine D1 receptor, SCH 23390, behavioral flexibility, strategy switching, perseveration
- MeSH terms
- Animals, Benzazepines, Cues, Discrimination Learning, Limbic System, Male, Microinjections, Receptors, Dopamine D1, Dopamine Antagonists, Maze Learning, Rats, Long-Evans, Rats
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