The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
BDNF genotype moderates the relation between physical activity and depressive symptoms.
Open accessAbstract
OBJECTIVE: To test whether the BDNF gene interacts with exercise to predict depressive symptoms. Physical activity is associated with a range of positive health outcomes, including fewer depressive symptoms. One plausible mechanism underlying these findings involves Brain-Derived Neurotrophic Factor (BDNF), a protein hypothesized to limit or repair the damage caused by stress. Physical activity increases expression of BDNF, which may enhance brain health. BDNF expression is controlled by the BDNF gene. Compared with individuals without a BDNF met allele, met-allele carriers have a lower expression of BDNF, which has been associated with Major Depressive Disorder. DESIGN: Eighty-two healthy adolescent girls were genotyped for the BDNF val66met polymorphism, and their depressive symptoms and physical activity were assessed using questionnaires. MAIN OUTCOME MEASURES: BDNF genotype, Children's Depression Inventory, and the Physical Activity Questionnaire for Older Children and Adolescents. RESULTS: The BDNF polymorphism was found to moderate the relation between exercise and depressive symptoms: being physically active was protective for girls with a BDNF met allele (fewer depressive symptoms) but not for girls with the val/val polymorphism. CONCLUSION: By integrating psychological and biological factors, the present study enhances our understanding of how physical activity contributes to resilience to psychopathology.
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“Lastly, adolescent girls with an allele for high BDNF received no protective effects against depression and anxiety symptoms by avoiding physical inactivity, while those with the allele causing lower BDNF level were protected (330).”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [330]
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Exercise: a behavioral intervention to enhance brain health and plasticity
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Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
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Flöel, A., & Knecht, S. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3293-7_20
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Wolf, S., & Hautzinger, M. (2011) · Psychotherapeut · doi:10.1007/s00278-011-0854-z
McGrady, A. V., & Moss, D. (2013) · Springer eBooks · doi:10.1007/978-1-4419-1379-1_2
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Caudle, T. (2015) · John Spoor Broome Library Institutional Repository (California State University)
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Pearson‐Fuhrhop, K. M., & Cramer, S. C. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9780511995590.005
Baker, S. (2018) · ORCA Online Research @Cardiff (Cardiff University)
The Influence of Physical Activity on Psychological Well-Being Among Adolescents and Emerging Adults
McPhie, M. L. (2017) · YorkSpace (York University)
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小西, 尚. (2012) · Medical Entomology and Zoology
Crump, C. (2016) · Carleton University's Institutional Repository (MacOdrum Library, Carleton University) · doi:10.22215/etd/2016-11447
Karabay, D., Tanık, F., Keskin, M., Öztürk, O., Kurt, M., & Kaya, D. Ö. (2023) · Ahi Evran Medical Journal · doi:10.46332/aemj.1221714
Molecular and bioinformatics evaluation of PRNP as a candidate gene for successful suicidal behavior
Cun, E., Can, H., Köseoğlu, A. E., Alak, S. E., Koyuncu, G., & Ün, C. (2023) · Annales Médico-psychologiques revue psychiatrique · doi:10.1016/j.amp.2023.10.003
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İşgören, Y. D. (2025) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub706.c3010
Yin, X., Peng, H., Li, Y., Song, Y., Chen, L., Yao, N., Li, P., He, Z., Chen, H., Huang, L., et al. (2026) · Brain and Behavior · doi:10.1002/brb3.71423
Chmiel, J., & Kopańska, M. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15135025
Technology of neurorehabilitation: outcome measurement and diagnostic technology
Selzer, M. E., Clarke, S., Cohen, L. G., Kwakkel, G., & Miller, R. H. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9780511995590.003
Metadata
- Authors
- Mata, J., Thompson, R. J., & Gotlib, I. H.
- Affiliations
- Stanford University (US)
- Venue
- Health Psychology
- Published
- 2010
- Volume
- 29
- Issue
- 2
- Pages
- 130-133
- ISSN
- 0278-6133 (ISSN-L)
- 1930-7810
- PMC
- PMC2847262
- OpenAlex
- W2096111444
- Cited by
- 119
- References
- 49
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 8 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 8 · 2016: 7 · 2015: 12 · 2014: 11 · 2013: 11 · 2012: 16
- FWCI
- 10.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Health Psychology (publishedVersion)
- PubMed (publishedVersion)
- MADOC (University of Mannheim) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Fundaçã para a Ciência e a Tecnologia (SFRH/BPD/35953/2007)
- Deutsche Forschungsgemeinschaft (Wi3496/41)
- National Institute of Mental Health (MH74849)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Keywords
- brain-derived neurotrophic factor, BDNF Val66Met polymorphism, physical activity, depressive symptoms, gene-environment interaction, adolescents, girls, major depressive disorder
- MeSH terms
- Adolescent, Alleles, Child, Depression, Female, Gene Frequency, Genotype, Humans, Motor Activity, Personality Inventory, Polymorphism, Genetic, Exercise, Brain-Derived Neurotrophic Factor
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