Cited by 119Physical Activity and HealthNeurotransmitter Receptor Influence on BehaviorGenetics and Physical Performance

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BDNF genotype moderates the relation between physical activity and depressive symptoms.

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Mata, Jutta, Thompson, Renee J., Gotlib, Ian H.·2010·Health Psychology

DOI 10.1037/a0017261PMC PMC2847262

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Abstract

OBJECTIVE: To test whether the BDNF gene interacts with exercise to predict depressive symptoms. Physical activity is associated with a range of positive health outcomes, including fewer depressive symptoms. One plausible mechanism underlying these findings involves Brain-Derived Neurotrophic Factor (BDNF), a protein hypothesized to limit or repair the damage caused by stress. Physical activity increases expression of BDNF, which may enhance brain health. BDNF expression is controlled by the BDNF gene. Compared with individuals without a BDNF met allele, met-allele carriers have a lower expression of BDNF, which has been associated with Major Depressive Disorder. DESIGN: Eighty-two healthy adolescent girls were genotyped for the BDNF val66met polymorphism, and their depressive symptoms and physical activity were assessed using questionnaires. MAIN OUTCOME MEASURES: BDNF genotype, Children's Depression Inventory, and the Physical Activity Questionnaire for Older Children and Adolescents. RESULTS: The BDNF polymorphism was found to moderate the relation between exercise and depressive symptoms: being physically active was protective for girls with a BDNF met allele (fewer depressive symptoms) but not for girls with the val/val polymorphism. CONCLUSION: By integrating psychological and biological factors, the present study enhances our understanding of how physical activity contributes to resilience to psychopathology.

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“…depressive symptoms, particularly in girls with at least one met-allele of the BDNF-gene - which is associated with less BDNF protein release in the brain and higher depressive symptoms - compared with girls with the same genotype who engage in little exercise (Mata, Thompson, & Gotlib, 2010).”
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Authors: Mata, J., Thompson, R. J., & Gotlib, I. H.
Affiliations: Stanford University (US)
ORCID: Mata, Jutta
Thompson, Renee J.
Gotlib, Ian H.
Venue: Health Psychology
Publisher: American Psychological Association (APA)
Published: 2010
Volume: 29
Issue: 2
Pages: 130-133
ISSN: 0278-6133 (ISSN-L)
1930-7810
DOI: 10.1037/a0017261
PMC: PMC2847262
OpenAlex: W2096111444
Cited by: 119
References: 49
Citations by year: 2026: 3 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 8 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 8 · 2016: 7 · 2015: 12 · 2014: 11 · 2013: 11 · 2012: 16
FWCI: 10.40
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Health Psychology (publishedVersion)
PubMed (publishedVersion)
MADOC (University of Mannheim) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Fundaçã para a Ciência e a Tecnologia (SFRH/BPD/35953/2007)
Deutsche Forschungsgemeinschaft (Wi3496/41)
National Institute of Mental Health (MH74849)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
Keywords: brain-derived neurotrophic factor, BDNF Val66Met polymorphism, physical activity, depressive symptoms, gene-environment interaction, adolescents, girls, major depressive disorder
MeSH terms: Adolescent, Alleles, Child, Depression, Female, Gene Frequency, Genotype, Humans, Motor Activity, Personality Inventory, Polymorphism, Genetic, Exercise, Brain-Derived Neurotrophic Factor

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BDNF genotype moderates the relation between physical activity and depressive symptoms.

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