The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
BDNF genotype moderates the relation between physical activity and depressive symptoms.
Open accessAbstract
OBJECTIVE: To test whether the BDNF gene interacts with exercise to predict depressive symptoms. Physical activity is associated with a range of positive health outcomes, including fewer depressive symptoms. One plausible mechanism underlying these findings involves Brain-Derived Neurotrophic Factor (BDNF), a protein hypothesized to limit or repair the damage caused by stress. Physical activity increases expression of BDNF, which may enhance brain health. BDNF expression is controlled by the BDNF gene. Compared with individuals without a BDNF met allele, met-allele carriers have a lower expression of BDNF, which has been associated with Major Depressive Disorder. DESIGN: Eighty-two healthy adolescent girls were genotyped for the BDNF val66met polymorphism, and their depressive symptoms and physical activity were assessed using questionnaires. MAIN OUTCOME MEASURES: BDNF genotype, Children's Depression Inventory, and the Physical Activity Questionnaire for Older Children and Adolescents. RESULTS: The BDNF polymorphism was found to moderate the relation between exercise and depressive symptoms: being physically active was protective for girls with a BDNF met allele (fewer depressive symptoms) but not for girls with the val/val polymorphism. CONCLUSION: By integrating psychological and biological factors, the present study enhances our understanding of how physical activity contributes to resilience to psychopathology.
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“Lastly, adolescent girls with an allele for high BDNF received no protective effects against depression and anxiety symptoms by avoiding physical inactivity, while those with the allele causing lower BDNF level were protected (330).”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [330]
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‘Small Changes' to Diet and Physical Activity Behaviors for Weight Management
Hills, A. P., Byrne, N. M., Lindstrom, R. C., & Hill, J. O. (2013) · Obesity Facts · doi:10.1159/000345030 · Cited by 9,526
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
A review of correlates of physical activity of children and adolescents
SALLIS, J. F., PROCHASKA, J. J., & TAYLOR, W. C. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200005000-00014 · Cited by 4,421
Neurotrophins: Roles in Neuronal Development and Function
Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394
da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,015
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A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375
Exercise: a behavioral intervention to enhance brain health and plasticity
Cotman, C. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02143-4 · Cited by 2,739
Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
Chen, Z.-Y., Jing, D., Bath, K. G., Ieraci, A., Khan, T., Siao, C.-J., Herrera, D. G., Toth, M., Yang, C., McEwen, B. S., et al. (2006) · Science · doi:10.1126/science.1129663 · Cited by 1,340
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Lack of Exercise Is a Major Cause of Chronic Diseases
Booth, F. W., Roberts, C. K., & Laye, M. J. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110025 · Cited by 2,575
Bridging animal and human models of exercise-induced brain plasticity
Voss, M. W., Vivar, C., Kramer, A. F., & van Praag, H. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.08.001 · Cited by 1,030
Phillips, C. (2017) · Neural Plasticity · doi:10.1155/2017/7260130 · Cited by 478
Physical Activity and Cognitive Vitality
Prakash, R. S., Voss, M. W., Erickson, K. I., & Kramer, A. F. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010814-015249 · Cited by 376
Beyond risk, resilience, and dysregulation: Phenotypic plasticity and human development
Belsky, J., & Pluess, M. (2013) · Development and Psychopathology · doi:10.1017/s095457941300059x · Cited by 395
Metadata
- Authors
- Mata, J., Thompson, R. J., & Gotlib, I. H.
- Affiliations
- Stanford University (US)
- Venue
- Health Psychology
- Published
- 2010
- Volume
- 29
- Issue
- 2
- Pages
- 130-133
- ISSN
- 0278-6133 (ISSN-L)
- 1930-7810
- PMC
- PMC2847262
- OpenAlex
- W2096111444
- Cited by
- 119
- References
- 49
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 8 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 8 · 2016: 7 · 2015: 12 · 2014: 11 · 2013: 11 · 2012: 16
- FWCI
- 10.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Health Psychology (publishedVersion)
- PubMed (publishedVersion)
- MADOC (University of Mannheim) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Fundaçã para a Ciência e a Tecnologia (SFRH/BPD/35953/2007)
- Deutsche Forschungsgemeinschaft (Wi3496/41)
- National Institute of Mental Health (MH74849)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Keywords
- brain-derived neurotrophic factor, BDNF Val66Met polymorphism, physical activity, depressive symptoms, gene-environment interaction, adolescents, girls, major depressive disorder
- MeSH terms
- Adolescent, Alleles, Child, Depression, Female, Gene Frequency, Genotype, Humans, Motor Activity, Personality Inventory, Polymorphism, Genetic, Exercise, Brain-Derived Neurotrophic Factor
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