The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Dynamic functional connectivity in bipolar disorder is associated with executive function and processing speed: A preliminary study
Open accessAbstract
OBJECTIVE: Disturbances in functional connectivity have been suggested to contribute to cognitive and emotion processing deficits observed in bipolar disorder (BD). Functional connectivity between medial prefrontal cortex (mPFC) and other brain regions may be particularly abnormal. The goal of the present study was to characterize the temporal dynamics of the default mode network (DMN) connectivity in BD and examine its association with cognition. METHOD: In a preliminary study, euthymic BD (n = 15) and healthy comparison (HC, n = 19) participants underwent resting-state functional MRI, using high-resolution sequences adapted from the Human Connectome Project, and completed neuropsychological measures of processing speed and executive function. A seed-based approach was used to measure DMN correlations in each participant, with regions of interest in the mPFC, posterior cingulate cortex (PCC), and lateral parietal cortex. Subsequently, to characterize temporal dynamics, correlational analyses between the mPFC and other DMN nodes were repeated using a sliding-window correlational analysis with subsets of the time series. RESULTS: When averaged across the entire scan, there were no group differences in overall connectivity strength between the mPFC and other regions of the DMN. However, dynamic connectivity between the mPFC and PCC was altered in BD, such that connectivity was less variable (i.e., more rigid) over time. Decreased connectivity variability was associated with slower processing speed and reduced cognitive set-shifting in BD patients. CONCLUSIONS: Variability in resting-state functional connectivity may be an index of internetwork flexibility that is reduced in BD and a correlate of ongoing cognitive impairment during periods of euthymia. (PsycINFO Database Record
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“In depression (the other pole), the precision might crash for positive priors, leading to the state described earlier of hypo-learning and negativity (68, 69).”
From Predictive coding and neurocomputational psychiatry: a mechanistic framework for understanding mental disorders (2026) · cites this paper as [68]
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Effects of light on brain-state dynamics and energy landscape
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Altered EEG microstate dynamics reflect depressive symptoms in temporal lobe epilepsy
Bornazyan, K., Oh, L. S., Ho, V., Lucas, M., Qing, K., Deng, D., King‐Stephens, D., Sazgar, M., Mnatsakanyan, L., Pizzagalli, D. A., et al. (2026) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2026.111205
Metadata
- Authors
- Nguyen, T. T., Kovacevic, S., Dev, S. I., Lu, K., Liu, T. T., & Eyler, L. T.
- Affiliations
- VA San Diego Healthcare System (US)
- San Diego State University (US)
- University of California San Diego (US)
- Venue
- Neuropsychology
- Published
- 2017-01
- Volume
- 31
- Issue
- 1
- Pages
- 73-83
- ISSN
- 0894-4105 (ISSN-L)
- 1931-1559
- PMC
- PMC5471616
- OpenAlex
- W2538606748
- Cited by
- 109
- References
- 67
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 11 · 2023: 11 · 2022: 7 · 2021: 33 · 2020: 17 · 2019: 7 · 2018: 6 · 2017: 3
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuropsychology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (5r01mh083968-05)
- National Institute of Mental Health (R01-MH083968, T32MH019934)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- bipolar disorder, dynamic functional connectivity, default mode network, medial prefrontal cortex, posterior cingulate cortex, processing speed, executive function, set-shifting, cognitive flexibility, euthymia, cognitive impairment
- MeSH terms
- Adult, Bipolar Disorder, Brain, Brain Mapping, Cognition, Cognition Disorders, Emotions, Female, Gyrus Cinguli, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Neuropsychological Tests, Parietal Lobe, Psychometrics, Reaction Time, Reference Values, Prefrontal Cortex, Executive Function
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