The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Treatment refusal and premature termination in psychotherapy, pharmacotherapy, and their combination: A meta-analysis of head-to-head comparisons.
Abstract
The purpose of this meta-analysis was to examine rates of treatment refusal and premature termination for pharmacotherapy alone, psychotherapy alone, pharmacotherapy plus psychotherapy, and psychotherapy plus pill placebo treatments. A systematic review of the literature resulted in 186 comparative trials that included a report of treatment refusal and/or premature termination for at least 2 of the 4 treatment conditions. The data from these studies were pooled using a random-effects analysis. Odds Ratio effect sizes were then calculated to compare the rates between treatment conditions, once across all studies and then again for specific client disorder categories. An average treatment refusal rate of 8.2% was found across studies. Clients who were assigned to pharmacotherapy were 1.76 times more likely to refuse treatment compared with clients who were assigned psychotherapy. Differences in refusal rates for pharmacotherapy and psychotherapy were particularly evident for depressive disorders, panic disorder, and social anxiety disorder. On average, 21.9% of clients prematurely terminated their treatment. Across studies, clients who were assigned to pharmacotherapy were 1.20 times more likely to drop out compared with clients who were assigned to psychotherapy. Pharmacotherapy clients with anorexia/bulimia and depressive disorders dropped out at higher rates compared with psychotherapy clients with these disorders. Treatment refusal and dropout are significant problems in both psychotherapy and pharmacotherapy and providers of these treatments should seek to employ strategies to reduce their occurrence. (PsycINFO Database Record
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“Therefore, non-adherence can have negative consequences for patients and can increase health care costs [17].”
From Efficacy and Acceptance of Cognitive Behavioral Therapy in Adults with Chronic Fatigue Syndrome: A Meta-analysis. (2024) · cites this paper as [17]
In the citing paper
“If a treatment is not acceptable to patients despite demonstrated positive outcomes, it may not be effective in practice [17].”
From Efficacy and Acceptance of Cognitive Behavioral Therapy in Adults with Chronic Fatigue Syndrome: A Meta-analysis. (2024) · cites this paper as [17]
In the citing paper
“Currently, in study reports, specific forms of drop-out rates are seldom reported [17], and a consistent definition of drop-out is lacking [28].”
From Efficacy and Acceptance of Cognitive Behavioral Therapy in Adults with Chronic Fatigue Syndrome: A Meta-analysis. (2024) · cites this paper as [17]
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“(6) About 20% of patients drop out of psychotherapy, even more of pharmacotherapy (Swift et al., 2017), with patients apparently experiencing the treatments as not acceptable.”
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“In Tufekcioglu et al. (2013), the authors have shown that alliance ruptures occur more often in the therapeutic alliance of patients with PD than in patients with non-PD.”
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“Very similar to estimates of attrition derived from psychotherapy and pharmacotherapy generally (i.e., 19.7 to 21.9%; Swift & Greenberg, 2012; Swift et al., 2017), approximately one in five participants randomized to an MBI or control condition did not complete post-treatment assessments (19.”
MethodInfluentialThe Relationship Between Dropout and Outcome in Naturalistic Cognitive Behavior Therapy
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“Given the inconsistent findings in this area (and surprisingly little research overall; e.g., Fernandez et al., 2015; Swift et al., 2017), more research is needed to better understand the relationship between symptom change during CBT and dropout.”
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“The CACE modeling approach can also be used to address participants who prematurely discontinue treatment, which is common (Swift et al., 2017).”
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“…to the use of pharmacologic therapies for PTSD, patients can have a higher reluctance to initiating pharmacologic therapy vs. psychotherapy (Swift et al., 2017) and higher dropout rates vs. psychotherapy (Swift et al., 2017) based on unwanted side effects from the drugs (Williams et al., 2022).”
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“The discontinuation rate in pharmacotherapy is still 1.76 times higher than in psychotherapy (Swift et al., 2017).”
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“…disorders (DR disaggregated by disorder) Individual, group and online Gersh et al. (2017) 45 2224 GAD Individual Swift, Greenberg, Tompkins, and Parkin (2017) 182 17891 Various disorders Individual and group Leeuwerik, Cavanagh and Strauss (2019) 123 5627 OCD Individual and group Lewis,…”
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“Second and related, this lack of information on the content of the treatment and the reasons for dropout prevents a more detailed analysis of an association between treatment type and dropout, and their potential interaction with sociodemographic variables; this would be relevant given the difference in dropout betwee…”
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“The average dropout rate of 13% suggests that EDT is tolerated similarly to psychotherapy in general (Swift et al. 2017), and we found no indication of differences in dropout rates compared to active control conditions.”
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“Studies show that community and client samples alike tend to prefer psychotherapy over pharmacotherapy (Swift et al., 2017), and that laypersons tend to prefer therapy activities high on therapist directive-ness, emotional intensity and unconditional support (Cooper et al., 2019; Heinze et al.,…”
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“A further meta-analysis that utilised the data of 186 comparative trials found that both treatment refusal and premature treatment termination were linked with a non-preferred treatment modality [12].”
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Goldman, R. E., Hilsenroth, M. J., Gold, J. R., Cersosimo, B. H., Levy, S. R., & Owen, J. J. (2018) · Journal of Psychotherapy Integration · doi:10.1037/int0000124 · Cited by 5
Psychotherapy for Mixed Depression and Mixed Mania
O’Brien, B., Lee, D. J., Swann, A. C., Mathew, S. J., & Lijffijt, M. (2019) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2019.10.014 · Cited by 5
Kan, K., Feenstra, T., de Vries, S. O., Visser, E., Schoevers, R. A., & Jörg, F. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.07.010 · Cited by 5
A cohort study of engagement in telehealth psychotherapy versus in-person services
Gibbons, M. B. C., Duong, L. A., Chiu, R. Y., Crits-Christoph, P. F., Gallop, R., Mandell, D. S., Barg, O., Newman, C. F., Brown, L. A., & Oquendo, M. A. (2024) · Psychotherapy Research · doi:10.1080/10503307.2024.2375231 · Cited by 5
“An estimated 19% of individuals receiving mental health services in a nationally representative sample (Olfson et al., 2009) and 22% of individuals receiving psychotherapy as part of randomized controlled trials (Swift et al., 2017) terminate psychotherapy prematurely.”
Lipner, L. M., Katz, M., Tzor, K., Amar, A., & Yonatan‐Leus, R. (2025) · Psychotherapy Research · doi:10.1080/10503307.2025.2551067 · Cited by 4
“…termination from psychotherapy ranges from 19.7% to 46.86% across different populations and treatment contexts (Sharf et al., 2010; Swift & Greenberg, 2012; Swift et al., 2017; Wierzbicki & Pekarik, 1993), representing a substantial percentage of patients whose treatment outcomes remain unclear.”
InfluentialUrmanche, A. A., Lipner, L. M., Bloch‐Elkouby, S., Hunter, E., Kaufmann, J., Warren, J. T., Weil, G. T., Eubanks, C. F., & Muran, J. C. (2021) · Counselling Psychology Quarterly · doi:10.1080/09515070.2021.1997916 · Cited by 4
“Based on recommendations to evaluate the session(s) preceding premature termination (Swift et al., 2017), some promising and innovative work has been conducted with Turkish students (Gülüm, Soygüt, & Safran, 2018) and adolescents (O’Keeffe, Martin, Target, & Midgley, 2019), and we hope to…”
MethodGorrell, S., Rienecke, R. D., Duffy, A., Huston, E. M., Mehler, P. S., Johnson, C., Manwaring, J. L., McClanahan, S. F., Blalock, D. V., & Grange, D. L. (2022) · Eating Disorders · doi:10.1080/10640266.2021.2011648 · Cited by 4
“A considerable literature has examined premature termination from psychotherapy treatment across broader patient populations (Swift et al., 2017).”
BackgroundGumz, A., Daubmann, A., Erices, R., Berger, J., Reuter, L., & Kästner, D. (2024) · Psychotherapy Research · doi:10.1080/10503307.2024.2327443 · Cited by 4
“At the same time, there are still many patients who do not adequately benefit from their psychotherapy (Barkham & Lambert, 2021; Cuijpers et al., 2021), and on average up to a quarter of all patients drop out of therapy prematurely (Fernandez et al., 2015; Swift et al., 2017).”
Neurobiological Foundations of Psychotherapies
Guina, J., Kay, J., & Yatim, F. (2024) · Springer eBooks · doi:10.1007/978-3-030-51366-5_168 · Cited by 3
Moments of disappointment in art therapy: patients’ perspectives
Vulcan, M., & Goldner, L. (2025) · International Journal of Art Therapy · doi:10.1080/17454832.2025.2468377 · Cited by 3
“Premature termination of psychotherapy or drop-out, i.e. a patient’s unilateral termination of services prior to completion of a recommended course of psychological treatment (Swift et al., 2012; Swift et al., 2017), is a widespread clinical phenomenon.”
Tait, J., Kellett, S., & Delgadillo, J. (2025) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2025.103003 · Cited by 4
Leonidaki, V., & Constantinou, M. (2021) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.2669 · Cited by 3
Pfund, R. A., Valencia, A. J., Hudson, E., Ginley, M. K., & Whelan, J. P. (2024) · Journal of Gambling Studies · doi:10.1007/s10899-024-10349-9 · Cited by 3
“The continued enhancement of engaging prospective clients yielded another 9% gain and a show rate approaching the 92% attendance rate for initial sessions for other mental health concerns (Swift et al., 2017).”
Generation of fundamental soliton in the presence of initial linear chirp
Kaczmarek, T. (2004) · Prace Naukowe Uniwersytetu Ekonomicznego we Wrocławiu · Cited by 3
Lenz, L., König, H., Leitner, M., & Hajek, A. (2025) · BJPsych Open · doi:10.1192/bjo.2025.10849 · Cited by 3
“In their meta-analysis, Swift et al 12 found an overall treatment refusal rate of 8.2% and an overall premature termination rate of 21.9%.”
InfluentialTakahashi, N., Takatsuki, K., Kasahara, S., & Yabuki, S. (2021) · Journal of Back and Musculoskeletal Rehabilitation · doi:10.3233/bmr-200292 · Cited by 2
Physiological effects of Therapeutic Body Wraps in healthy volunteers: An observational study
Korogod, N., Skuza, K., Bangerter, G., & Opsommer, E. (2022) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2022.07.020 · Cited by 2
Muñoz‐Navarro, R., Pérez‐Jover, V., Esteller-Collado, G., Román, C. J. V.-D. H., Salgueiro, M., Llorca, A., Malonda-Vidal, E., Canet-Cortell, V., Moraga-García, M. J., Coloma‐Carmona, A., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0320857 · Cited by 2
“A meta-analysis by Swift et al. [49] found that patients on pharmacotherapy had a higher dropout rate than patients receiving psychotherapy alone.”
Cunningham, C. E., Rimas, H. L., Sivayoganathan, T., Stewart, B., Munn, C., Zipursky, R. B., Christensen, B. K., & Furimsky, I. (2020) · Emerging Adulthood · doi:10.1177/2167696820946894 · Cited by 3
“Systematic reviews conclude that patients offered medication are more likely to refuse treatment or to subsequently drop out of treatment than those offered psychotherapy (Swift et al., 2017).”
BackgroundMotivational Interviewing Enhances Group Cognitive Behavioral Therapy for Anxiety Disorders
Strodl, E. S., & Yang, J. (2021) · Journal of Cognitive Psychotherapy · doi:10.1891/jcpsy-d-20-00025 · Cited by 3
Treating Later-Life Depression
Steffen, A. M., Thompson, L. W., & Gallagher-Thompson, D. E. (2021) · doi:10.1093/med-psych/9780190068431.001.0001 · Cited by 2
Ryttinger, R., Serralta, F. B., Pires, N., Basto, I., Melo, G. R., & Ribeiro, E. (2022) · Studies in Psychology Estudios de Psicología · doi:10.1080/02109395.2022.2132750 · Cited by 2
“In the current study, dropout is defined as a premature and unilateral discontinuation after the client begins the psychotherapy, before recovering from their suffering and without the agreement of the therapist (Swift et al., 2017).”
BackgroundInfluentialJohnson, R. J. (2020) · Psychology and Mental Health Care · doi:10.31579/2637-8892/067 · Cited by 2
Cascia, C. L., Ferraro, L., Seminerio, F., Scaglione, A., Maniaci, G., Matranga, D., Sideli, L., Colli, G., Sartorio, C., Paglia, F. L., et al. (2020) · Minerva Psichiatrica · doi:10.23736/s0391-1772.20.02092-0 · Cited by 2
„Talking cures“ – Sprache als Medium in Psychotherapien
Gumz, A., & Strauss, B. M. (2022) · Psychotherapeut · doi:10.1007/s00278-022-00578-x · Cited by 2
“Immerhin bis zu ein Viertel aller Patienten im Durchschnitt bricht die Therapie vorzeitig ab (Cahill et al. 2003; Fernandez et al. 2015; Swift und Greenberg 2012; Swift et al. 2017).”
BackgroundPreventing Dropout in Research, Assessment and Treatment with Refugees - a guidelinePreprint
Semmlinger, V., & Ehring, T. W. (2020) · doi:10.31234/osf.io/nukv3 · Cited by 2
Cognitive-Behavioral Therapies 101
Steffen, A. M., Thompson, L. W., & Gallagher-Thompson, D. E. (2021) · Oxford University Press eBooks · doi:10.1093/med-psych/9780190068431.003.0004 · Cited by 2
Professional Development Resources
Steffen, A. M., Thompson, L. W., & Gallagher-Thompson, D. E. (2021) · Oxford University Press eBooks · doi:10.1093/med-psych/9780190068431.005.0001 · Cited by 2
Metadata
- Authors
- Swift, J. K., Greenberg, R. P., Tompkins, K. A., & Parkin, S. R.
- Affiliations
- Idaho State University (US)
- SUNY Upstate Medical University (US)
- University of Alaska Anchorage (US)
- ORCID
- Swift, Joshua K.
- Venue
- Psychotherapy
- Published
- 2017-03
- Volume
- 54
- Issue
- 1
- Pages
- 47-57
- ISSN
- 0033-3204 (ISSN-L)
- 1939-1536
- OpenAlex
- W2593514681
- Cited by
- 167
- References
- 45
- Citations by year
- 2026: 11 · 2025: 16 · 2024: 22 · 2023: 10 · 2022: 21 · 2021: 44 · 2020: 13 · 2019: 9 · 2018: 17 · 2017: 3
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychotherapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Keywords
- treatment refusal, early termination, treatment discontinuation, pharmacotherapy, combined psychotherapy and pharmacotherapy, depressive disorders, panic disorder, social anxiety disorder, anorexia nervosa, bulimia nervosa, medication adherence
- MeSH terms
- Combined Modality Therapy, Humans, Object Attachment, Patient Dropouts, Psychotherapy, Psychotropic Drugs, Psychotherapeutic Processes, Placebo Effect, Treatment Refusal
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