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Trichromatic color vision with only two spectrally distinct photopigments
Abstract
Protanomaly is a common, X-linked abnormality of color vision. Like people with normal color vision, protanomalous observers are trichromatic, but their ability to discriminate colors in the red-green part of the spectrum is reduced because the photopigments that mediate discrimination in this range are abnormally similar. Whereas normal subjects have pigments whose wavelengths of peak sensitivity differ by about 30 nm, the peak wavelengths for protanomalous observers are thought to differ by only a few nanometers. We found, however, that although this difference occurred in some protanomalous subjects, others had pigments whose peak wavelengths were identical. Genetic and psychophysical results from the latter class indicated that limited red-green discrimination can be achieved with pigments that have the same peak wavelength sensitivity and that differ only in optical density. A single amino acid substitution was correlated with trichromacy in these subjects, suggesting that differences in pigment sequence may regulate the optical density of the cone.
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“In addition to the amino acids that shift the spectrum, protanomlous color vision may also arise from amino acid differences that do not shift the relative peak sensitivity of the underlying M pigments, but instead increase the optical density of one pigment relative to the other (Neitz et al., 1999).”
From The genetics of normal and defective color vision (2011) · cites this paper as Neitz et al., 1999
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“X-chromosome opsin gene arrays underlying the dichromatic form, protanopia, either have a single opsin gene that encodes an M pigment, or have multiple genes in which the first two encode opsins that produce M pigments that are identical in spectra (Jagla, Jägle, Hayashi, Sharpe & Deeb, 2002, Nathans et al., 1986a, Neitz, Neitz, He & Shevell, 1999, Neitz et al., 2004).”
From The genetics of normal and defective color vision (2011) · cites this paper as Neitz, Neitz, He & Shevell, 1999
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Cited by
Sorted by citations
The genetics of normal and defective color vision
Neitz, J., & Neitz, M. (2011) · Vision Research · doi:10.1016/j.visres.2010.12.002 · Cited by 377
Self-citationMcBee, J. K., Palczewski, K., Baehr, W., & Pepperberg, D. R. (2001) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(01)00002-7 · Cited by 366
Metadata
- Authors
- Neitz, J., Neitz, M., He, J. C., & Shevell, S. K.
- Venue
- Nature Neuroscience
- Published
- 1999-10
- Volume
- 2
- Issue
- 10
- Pages
- 884-888
- ISSN
- 1097-6256
- 1546-1726
- Cited by
- 64
- References
- 0
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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